Browsing by Author "González, Jessica"

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  • Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika, 1986-; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2013)
    IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of ...
  • Islam, Abul, 1978-; Guiu Sagarra, Jordi, 1983-; Bergen, Dylan J.M.; de Pater, Emma; Ayllon, Verónica; Gama-Norton, Leonor; Ruiz Herguido, Cristina; González, Jessica; López Bigas, Núria; Menéndez, Pablo; Dzierzak, Elaine; Espinosa Blay, Lluís; Bigas Salvans, Anna (Rockefeller University Press, 2014)
    Hematopoietic stem cell (HSC) specification occurs in the embryonic aorta and requires Notch activation; however, most of the Notch-regulated elements controlling de novo HSC generation are still unknown. Here, we identify ...
  • Colomer Montañà, Carlota, 1990-; Margalef González, Pol, 1985-; González, Jessica; Vert, Anna; Bigas Salvans, Anna; Espinosa Blay, Lluís (Nature Publishing Group, 2018)
    BACKGROUND: Colorectal cancer is a common cause of death in developed countries. Progression from adenoma to invasive carcinoma requires accumulation of mutations starting with the Adenomatous Polyposis Coli (Apc) gene. ...
  • Bosch Presegué, Laia; Raurell Vila, Helena; Thackray, Joshua K.; González, Jessica; Casal, Carmen; Kane-Goldsmith, Noriko; Vizoso, Miguel; Brown, Jeremy P.; Gómez, Antonio; Ausió, Juan; Zimmermann, Timo; Esteller, Manel; Schotta, Gunnar; Singh, Prim B.; Serrano, Lourdes; Vaquero, Alejandro (Elsevier, 2017)
    HP1 is a structural component of heterochromatin. Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role in heterochromatin structure is unclear. Analysis of Hp1α-/-, ...
  • Porcheri, Cristina; Golan, Ohad; Calero-Nieto, Fernando J.; Thambyrajah, Roshana; Ruiz-Herguido, Cristina; Wang, Xiaonan; Catto, Francesca; Guillén, Yolanda; Sinha, Roshani, 1989-; González, Jessica; Kinston, Sarah J.; Mariani, Samanta A.; Maglitto, Antonio; Vink, Chris S.; Dzierzak, Elaine; Charbord, Pierre; Göttgens, Bertie; Espinosa Blay, Lluís; Sprinzak, David; Bigas Salvans, Anna (Wiley-Blackwell, 2020)
    Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium in cluster structures that protrude into the embryonic aortic lumen. Although much is known about the molecular characteristics of the developing ...
  • Gallardo Hernández, Fernando; Bertran, Joan; López Arribillaga, Erika, 1986-; González, Jessica; Menéndez, Silvia; Sánchez Güerri, Ignacio; Colomo Saperas, Luis Alberto; Iglesias Coma, Mar; Garrido, Marta; Santamaría-Babí, Luis Francisco; Torres, Ferran; Pujol Vallverdú, Ramon Maria; Bigas Salvans, Anna; Espinosa Blay, Lluís (Nature Publishing Group, 2018)
  • Solé, Laura; Lobo-Jarne, Teresa; Álvarez-Villanueva, Daniel; Alonso-Marañón, Josune; Guillén, Yolanda; Guix Arnau, Marta, 1974-; Sangrador, Irene; Rozalén, Catalina; Vert, Anna; Lop Gros, Joan; Salido Galeote, Marta; Bellosillo Paricio, Beatriz; García-Romero, Raquel; Garrido, Marta; González, Jessica; López Arribillaga, Erika, 1986-; Iglesias Coma, Mar; Celià-Terrassa, Toni; Bigas Salvans, Anna; Espinosa Blay, Lluís (Nature Research, 2022)
    Current therapy against colorectal cancer (CRC) is based on DNA-damaging agents that remain ineffective in a proportion of patients. Whether and how non-curative DNA damage-based treatment affects tumor cell behavior and ...
  • Gallardo Hernández, Fernando; Andrades, Evelyn; Iglesias, Arnau; González, Jessica; Solé, Laura; Guillén, Yolanda; Blanco Ares, Gonzalo, 1989-; Colomo Saperas, Luis Alberto; Gimeno, Eva; Conde Estévez, David; Rodríguez, Eva; Bielsa-Marsol, Isabel; Iglesias Coma, Mar; Bellosillo Paricio, Beatriz; Pujol Vallverdú, Ramon Maria; Regueiro, José R.; Bigas Salvans, Anna; Espinosa Blay, Lluís (American Society of Hematology, 2022)
    Current therapeutic approaches for Sézary syndrome (SS) do not achieve a significant improvement in long-term survival of patients, and they are mainly focused on reducing blood tumor burden to improve quality of life. ...
  • Sentís, Inés; González, Santi; Genescà, Eulalia; García Hernández, Violeta; Muiños, Ferran; González, Celia; López Arribillaga, Erika, 1986-; González, Jessica; Fernández-Ibarrondo, Lierni; Mularoni, Loris; Espinosa-Anke, Luis; Bellosillo Paricio, Beatriz; Ribera, Josep Maria; Bigas Salvans, Anna; González Pérez, Abel; López Bigas, Núria (BioMed Central, 2020)
    Background: Adult T cell acute lymphoblastic leukemia (T-ALL) is a rare disease that affects less than 10 individuals in one million. It has been less studied than its cognate pediatric malignancy, which is more prevalent. ...
  • García Hernández, Violeta; Arambilet, David; Guillén, Yolanda; Lobo-Jarne, Teresa; Maqueda, Maria; Gekas, Christos; González, Jessica; Iglesias, Arnau; Vega García, Nerea; Sentís Carreras, Inés 1990-; Trincado Alonso, Juan Luis, 1987-; Márquez-López, Ian; Heyn, Holger; Camós, Mireia; Espinosa Blay, Lluís; Bigas Salvans, Anna (Wiley, 2023)
    Understanding the molecular mechanisms that contribute to the appearance of chemotherapy resistant cell populations is necessary to improve cancer treatment. We have now investigated the role of β-catenin/CTNNB1 in the ...
  • Gekas, Christos; Teresa, D'Altri 1984-; Aligué, Rosa; González, Jessica; Espinosa Blay, Lluís; Bigas Salvans, Anna (Nature Publishing Group, 2016)
    Notch activation is instrumental in the development of most T-cell acute lymphoblastic leukemia (T-ALL) cases, yet Notch mutations alone are not sufficient to recapitulate the full human disease in animal models. We here ...