Browsing by Author "Gonatopoulos-Pournatzis, Thomas"

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  • An alternative splicing event amplifies evolutionary differences between vertebrates
    Gueroussov, Serge; Gonatopoulos-Pournatzis, Thomas; Irimia, Manuel; Raj, Bushra; Lin, Zhen-Yuan; Gingras, Anne-Claude; Blencowe, Benjamin J. (American Association for the Advancement of Science (AAAS), 2015)
    Alternative splicing (AS) generates extensive transcriptomic and proteomic complexity. However, the functions of species- and lineage-specific splice variants are largely unknown. Here we show that mammalian-specific ...
  • Misregulation of an activity-dependent splicing network as a common mechanism underlying autism spectrum disorders
    Quesnel-Vallières, Mathieu; Dargaei, Zahra; Irimia, Manuel; Gonatopoulos-Pournatzis, Thomas; Ip, Joanna Y.; Wu, Mingkun; Sterne-Weiler, Thimothy; Nakagawa, Shinichi; Woodin, Melanie A.; Blencowe, Benjamin J.; Cordes, Sabine P. (Elsevier, 2016)
    A key challenge in understanding and ultimately treating autism is to identify common molecular mechanisms underlying this genetically heterogeneous disorder. Transcriptomic profiling of autistic brains has revealed ...