Browsing by Author "Gispert López, Juan Domingo"

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  • Bucci, Marco; Savitcheva, Irina; Farrar, Gill; Salvadó, Gemma; Collij, Lyduine E.; Doré, Vincent; Gispert López, Juan Domingo; Gunn, Roger; Hanseeuw, Bernard; Hansson, Oskar; Shekari, Mahnaz; Lhommel, Renaud; Molinuevo, José Luis; Rowe, Christopher; Sur, Cyrille; Whittington, Alex; Buckley, Christopher, 1948-; Nordberg, Agneta (Springer, 2021)
    Background: [18F]flutemetamol PET scanning provides information on brain amyloid load and has been approved for routine clinical use based upon visual interpretation as either negative (equating to none or sparse amyloid ...
  • Cacciaglia, Raffaele; Salvadó, Gemma; Molinuevo, José Luis; Shekari, Mahnaz; Falcón, Carles; Operto, Grégory; Suárez-Calvet, Marc; Milà Alomà, Marta; Sala, Arianna; Rodriguez-Vieitez, Elena; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Blennow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Nature Research, 2022)
    Amyloid (Aβ) pathology is the earliest detectable pathophysiological event along the Alzheimer's continuum, which can be measured both in the cerebrospinal fluid (CSF) and by Positron Emission Tomography (PET). Yet, these ...
  • Milà Alomà, Marta; Salvadó, Gemma; Gispert López, Juan Domingo; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; Arenaza Urquijo, Eider M.; Crous-Bou, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    Introduction: The biological pathways involved in the preclinical stage of the Alzheimer's continuum are not well understood. Methods: We used NeuroToolKit and Elecsys® immunoassays to measure cerebrospinal fluid (CSF) ...
  • Caprioglio, Camilla; Minguillón, Carolina; Grau-Rivera, Oriol; Molinuevo, José Luis; Gispert López, Juan Domingo; AMYPAD Consortium (American Medical Association, 2023)
    Importance Individuals who are amyloid-positive with subjective cognitive decline and clinical features increasing the likelihood of preclinical Alzheimer disease (SCD+) are at higher risk of developing dementia. Some ...
  • Brugulat Serrat, Anna, 1986-; Sánchez Benavides, Gonzalo; Cacciaglia, Raffaele; Shekari, Mahnaz; Milà Alomà, Marta; Vilor Tejedor, Natàlia, 1988-; Operto, Grégory; Falcón, Carles; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; Minguillón, Carolina; Fauria, Karine; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (Springer, 2023)
    Purpose: To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged cognitively unimpaired (CU) participants. Methods: The 352 CU ...
  • Cacciaglia, Raffaele; Molinuevo, José Luis; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt Fombuena, Nina; Brugulat Serrat, Anna, 1986-; Esteller, Manel; Morán, Sebastián; Fauria, Karine; Gispert López, Juan Domingo; ALFA Study (Elsevier, 2019)
    The APOE-ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD). In cognitively unimpaired individuals, it has been related to altered brain morphology, function and earlier amyloid beta accumulation. ...
  • Cacciaglia, Raffaele; Molinuevo, José Luis; Falcón, Carles; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Blennow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; ALFA Study (Oxford University Press, 2020)
    Gray matter networks (GMn) provide essential information on the intrinsic organization of the brain and appear to be disrupted in Alzheimer's disease (AD). Apolipoprotein E (APOE)-ε4 represents the major genetic risk factor ...
  • Grau-Rivera, Oriol; Operto, Grégory; Falcón, Carles; Sánchez Benavides, Gonzalo; Cacciaglia, Raffaele; Brugulat Serrat, Anna, 1986-; Gramunt Fombuena, Nina; Salvadó, Gemma; Suárez-Calvet, Marc; Minguillón, Carolina; Iranzo, Alex; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (BioMed Central, 2020)
    Background: Mounting evidence links poor sleep quality with a higher risk of late-life dementia. However, the structural and cognitive correlates of insomnia are still not well understood. The study aims were to characterize ...
  • Grau-Rivera, Oriol; Navalpotro Gómez, Irene; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Arenaza Urquijo, Eider M.; Salvadó, Gemma; Sala Vila, Aleix; Shekari, Mahnaz; González de Echávarri, José Maria; Minguillón, Carolina; Niñerola-Baizán, Aida; Perissinotti, Andrés; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (BioMed Central, 2021)
    Background: Recognizing clinical manifestations heralding the development of Alzheimer's disease (AD)-related cognitive impairment could improve the identification of individuals at higher risk of AD who may benefit from ...
  • Pascau, Javier; Gispert López, Juan Domingo; Michaelides, Michael; Thanos, Panayotis K.; Volkow, Nora D.; Vaquero, Juan J.; Soto-Montenegro, Maria Luisa; Desco, Manuel (Springer, 2009)
    PURPOSE: We propose and compare different registration approaches to align small-animal PET studies and a procedure to validate the results by means of objective registration consistency measurements. PROCEDURES: We have ...
  • Falcón, Carles; Gascon Merlos, Mireia, 1984-; Molinuevo, José Luis; Operto, Grégory; Cirach, Marta; Gotsens, Xavier; Fauria, Karine; Arenaza Urquijo, Eider M.; Pujol Martí, Jesús, 1981-; Sunyer Deu, Jordi; Nieuwenhuijsen, Mark J.; Gispert López, Juan Domingo; Crous-Bou, Marta; ALFA Study (Wiley, 2021)
    Introduction: Urban environmental exposures might contribute to the incidence of Alzheimer's disease (AD). Our aim was to identify structural brain imaging correlates of urban environmental exposures in cognitively unimpaired ...
  • Sadeghi, Iman; Gispert López, Juan Domingo; Palumbo, Emilio; Muñoz-Aguirre, Manuel; Wucher, Valentin; D'Argenio, Valeria; Santpere Baró, Gabriel, 1981-; Navarro i Cuartiellas, Arcadi, 1969-; Guigó Serra, Roderic; Vilor Tejedor, Natàlia, 1988- (Elsevier, 2022)
    Neurodegenerative and neuropsychiatric disorders (ND-NPs) are multifactorial, polygenic and complex behavioral phenotypes caused by brain abnormalities. Large-scale collaborative efforts have tried to identify the genetic ...
  • Salvadó, Gemma; Molinuevo, José Luis; Brugulat Serrat, Anna, 1986-; Falcón, Carles; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Pavía Segura, Javier; Niñerola-Baizán, Aida; Perissinotti, Andrés; Lomeña, Francisco; Minguillón, Carolina; Fauria, Karine; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative (BioMed Central, 2019)
    Background: The Centiloid scale has been developed to standardize measurements of amyloid PET imaging. Reference cut-off values of this continuous measurement enable the consistent operationalization of decision-making for ...
  • Salvadó, Gemma; Milà Alomà, Marta; Shekari, Mahnaz; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Buckley, Christopher, 1948-; Farrar, Gill; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Wiley, 2021)
    Introduction: The association between cerebral amyloid-β accumulation and downstream CSF biomarkers is not fully understood, particularly in asymptomatic stages. Methods: In 318 cognitively unimpaired participants, we ...
  • Milà Alomà, Marta; Shekari, Mahnaz; Salvadó, Gemma; Gispert López, Juan Domingo; Arenaza Urquijo, Eider M.; Operto, Grégory; Falcón, Carles; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA Study (BioMed Central, 2021)
    Background: Understanding the changes that occur in the transitional stage between absent and overt amyloid-β (Aβ) pathology within the Alzheimer's continuum is crucial to develop therapeutic and preventive strategies. The ...
  • Popota, Foteini D.,1980- (Universitat Pompeu Fabra, 2014-11-27)
    Positron emission tomography (PET) has been well established the last years as a powerfull tool in research and clinical applications. Advances in technology have enabled the use of small animal PET imaging in preclinical ...
  • Popota, Foteini D.,1980-; Aguiar, Pablo; Herance Camacho, José Raul; Pareto, Deborah; Rojas, Santiago; Ros, Domènec; Pavía Segura, Javier; Gispert López, Juan Domingo (Institute of Electrical and Electronics Engineers (IEEE), 2012)
    The purpose of this work was to evaluate the performance of the microPET R4 system for rodents according to the NU 4-2008 standards of the National Electrical Manufacturers Association (NEMA) for small-animal positron ...
  • Blackman, Jonathan; Stankeviciute, Laura; Arenaza Urquijo, Eider M.; Suárez-Calvet, Marc; Sánchez Benavides, Gonzalo; Vilor Tejedor, Natàlia, 1988-; Iranzo, Alejandro; Molinuevo, José Luis; Gispert López, Juan Domingo; Coulthard, Elizabeth; Grau-Rivera, Oriol; European Prevention of Alzheimer’s Disease (EPAD) Consortium (Oxford University Press, 2022)
    Sleep abnormalities are prevalent in Alzheimer's disease, with sleep quality already impaired at its preclinical stage. Epidemiological and experimental data point to sleep abnormalities contributing to the risk of Alzheimer's ...
  • Falcón, Carles; Monté-Rubio, Gemma C.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Sánchez Valle, Raquel; Rami, Lorena; Bosch, Beatriz; Haass, Christian; Gispert López, Juan Domingo; Molinuevo, José Luis (Elsevier, 2019)
    Cerebrospinal fluid (CSF) YKL40 and sTREM2 are astroglial and microglial activity biomarkers, respectively. We assessed whether CSF YKL40 and sTREM2 baseline levels are associated with longitudinal brain volume and diffusivity ...
  • Altomare, Daniele; Grau-Rivera, Oriol; Gispert López, Juan Domingo; Minguillón, Carolina; Frisoni, Giovanni B.; AMYPAD Consortium (Wiley, 2022)
    Introduction: AMYPAD Diagnostic and Patient Management Study (DPMS) aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Here we present participants' baseline features and discuss the ...

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