Browsing by Author "Gispert López, Juan Domingo"

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  • A multisite analysis of the concordance between visual image interpretation and quantitative analysis of [18F]flutemetamol amyloid PET images
    Bucci, Marco; Savitcheva, Irina; Farrar, Gill; Salvadó, Gemma; Collij, Lyduine E.; Doré, Vincent; Gispert López, Juan Domingo; Gunn, Roger; Hanseeuw, Bernard; Hansson, Oskar; Shekari, Mahnaz; Lhommel, Renaud; Molinuevo, José Luis; Rowe, Christopher; Sur, Cyrille; Whittington, Alex; Buckley, Christopher, 1948-; Nordberg, Agneta (Springer, 2021)
    Background: [18F]flutemetamol PET scanning provides information on brain amyloid load and has been approved for routine clinical use based upon visual interpretation as either negative (equating to none or sparse amyloid ...
  • Age, sex and APOE-ε4 modify the balance between soluble and fibrillar β-amyloid in non-demented individuals: topographical patterns across two independent cohorts
    Cacciaglia, Raffaele; Salvadó, Gemma; Molinuevo, José Luis; Shekari, Mahnaz; Falcón, Carles; Operto, Grégory; Suárez-Calvet, Marc; Milà Alomà, Marta; Sala, Arianna; Rodriguez-Vieitez, Elena; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Blennow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Nature Research, 2022)
    Amyloid (Aβ) pathology is the earliest detectable pathophysiological event along the Alzheimer's continuum, which can be measured both in the cerebrospinal fluid (CSF) and by Positron Emission Tomography (PET). Yet, these ...
  • Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum
    Milà Alomà, Marta; Salvadó, Gemma; Gispert López, Juan Domingo; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; Arenaza Urquijo, Eider M.; Crous-Bou, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    Introduction: The biological pathways involved in the preclinical stage of the Alzheimer's continuum are not well understood. Methods: We used NeuroToolKit and Elecsys® immunoassays to measure cerebrospinal fluid (CSF) ...
  • APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals
    Cacciaglia, Raffaele; Molinuevo, José Luis; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt Fombuena, Nina; Brugulat Serrat, Anna, 1986-; Esteller, Manel; Morán, Sebastián; Fauria, Karine; Gispert López, Juan Domingo; ALFA Study (Elsevier, 2019)
    The APOE-ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD). In cognitively unimpaired individuals, it has been related to altered brain morphology, function and earlier amyloid beta accumulation. ...
  • APOE-ε4 shapes the cerebral organization in cognitively intact individuals as reflected by structural gray matter networks
    Cacciaglia, Raffaele; Molinuevo, José Luis; Falcón, Carles; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Blennow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; ALFA Study (Oxford University Press, 2020)
    Gray matter networks (GMn) provide essential information on the intrinsic organization of the brain and appear to be disrupted in Alzheimer's disease (AD). Apolipoprotein E (APOE)-ε4 represents the major genetic risk factor ...
  • Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults
    Grau-Rivera, Oriol; Operto, Grégory; Falcón, Carles; Sánchez Benavides, Gonzalo; Cacciaglia, Raffaele; Brugulat Serrat, Anna, 1986-; Gramunt Fombuena, Nina; Salvadó, Gemma; Suárez-Calvet, Marc; Minguillón, Carolina; Iranzo, Alex; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (BioMed Central, 2020)
    Background: Mounting evidence links poor sleep quality with a higher risk of late-life dementia. However, the structural and cognitive correlates of insomnia are still not well understood. The study aims were to characterize ...
  • Association of weight change with cerebrospinal fluid biomarkers and amyloid positron emission tomography in preclinical Alzheimer's disease
    Grau-Rivera, Oriol; Navalpotro Gómez, Irene; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Arenaza Urquijo, Eider M.; Salvadó, Gemma; Sala Vila, Aleix; Shekari, Mahnaz; González de Echávarri, José Maria; Minguillón, Carolina; Niñerola-Baizán, Aida; Perissinotti, Andrés; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (BioMed Central, 2021)
    Background: Recognizing clinical manifestations heralding the development of Alzheimer's disease (AD)-related cognitive impairment could improve the identification of individuals at higher risk of AD who may benefit from ...
  • Automated method for small-animal PET image registration with intrinsic validation
    Pascau, Javier; Gispert López, Juan Domingo; Michaelides, Michael; Thanos, Panayotis K.; Volkow, Nora D.; Vaquero, Juan J.; Soto-Montenegro, Maria Luisa; Desco, Manuel (Springer, 2009)
    PURPOSE: We propose and compare different registration approaches to align small-animal PET studies and a procedure to validate the results by means of objective registration consistency measurements. PROCEDURES: We have ...
  • Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population
    Falcón, Carles; Gascon Merlos, Mireia, 1984-; Molinuevo, José Luis; Operto, Grégory; Cirach, Marta; Gotsens, Xavier; Fauria, Karine; Arenaza Urquijo, Eider M.; Pujol Martí, Jesús, 1981-; Sunyer Deu, Jordi; Nieuwenhuijsen, Mark J.; Gispert López, Juan Domingo; Crous-Bou, Marta; ALFA Study (Wiley, 2021)
    Introduction: Urban environmental exposures might contribute to the incidence of Alzheimer's disease (AD). Our aim was to identify structural brain imaging correlates of urban environmental exposures in cognitively unimpaired ...
  • Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders
    Sadeghi, Iman; Gispert López, Juan Domingo; Palumbo, Emilio; Muñoz-Aguirre, Manuel; Wucher, Valentin; D'Argenio, Valeria; Santpere Baró, Gabriel, 1981-; Navarro i Cuartiellas, Arcadi, 1969-; Guigó Serra, Roderic; Vilor Tejedor, Natàlia, 1988- (Elsevier, 2022)
    Neurodegenerative and neuropsychiatric disorders (ND-NPs) are multifactorial, polygenic and complex behavioral phenotypes caused by brain abnormalities. Large-scale collaborative efforts have tried to identify the genetic ...
  • Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers
    Salvadó, Gemma; Molinuevo, José Luis; Brugulat Serrat, Anna, 1986-; Falcón, Carles; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Pavía Segura, Javier; Niñerola-Baizán, Aida; Perissinotti, Andrés; Lomeña, Francisco; Minguillón, Carolina; Fauria, Karine; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative (BioMed Central, 2019)
    Background: The Centiloid scale has been developed to standardize measurements of amyloid PET imaging. Reference cut-off values of this continuous measurement enable the consistent operationalization of decision-making for ...
  • Cerebral amyloid-β load is associated with neurodegeneration and gliosis: Mediation by p-tau and interactions with risk factors early in the Alzheimer's continuum
    Salvadó, Gemma; Milà Alomà, Marta; Shekari, Mahnaz; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Buckley, Christopher, 1948-; Farrar, Gill; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Wiley, 2021)
    Introduction: The association between cerebral amyloid-β accumulation and downstream CSF biomarkers is not fully understood, particularly in asymptomatic stages. Methods: In 318 cognitively unimpaired participants, we ...
  • Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile
    Milà Alomà, Marta; Shekari, Mahnaz; Salvadó, Gemma; Gispert López, Juan Domingo; Arenaza Urquijo, Eider M.; Operto, Grégory; Falcón, Carles; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA Study (BioMed Central, 2021)
    Background: Understanding the changes that occur in the transitional stage between absent and overt amyloid-β (Aβ) pathology within the Alzheimer's continuum is crucial to develop therapeutic and preventive strategies. The ...
  • Comparative study of dedicated Monte Carlo simulation codes for the performance evaluation of the small animal PET systems
    Popota, Foteini D.,1980- (Universitat Pompeu Fabra, 2014-11-27)
    Positron emission tomography (PET) has been well established the last years as a powerfull tool in research and clinical applications. Advances in technology have enabled the use of small animal PET imaging in preclinical ...
  • Comparison of the Performance Evaluation of the MicroPET R4 Scanner According to NEMA Standards NU 4-2008 and NU 2-2001
    Popota, Foteini D.,1980-; Aguiar, Pablo; Herance, J. Raúl; Pareto, Deborah; Rojas, Santiago; Ros, Domènec; Pavía Segura, Javier; Gispert López, Juan Domingo (Institute of Electrical and Electronics Engineers (IEEE), 2012)
    The purpose of this work was to evaluate the performance of the microPET R4 system for rodents according to the NU 4-2008 standards of the National Electrical Manufacturers Association (NEMA) for small-animal positron ...
  • Cross-sectional and longitudinal association of sleep and Alzheimer biomarkers in cognitively unimpaired adults
    Blackman, Jonathan; Stankeviciute, Laura; Arenaza Urquijo, Eider M.; Suárez-Calvet, Marc; Sánchez Benavides, Gonzalo; Vilor Tejedor, Natàlia, 1988-; Iranzo, Alejandro; Molinuevo, José Luis; Gispert López, Juan Domingo; Coulthard, Elizabeth; Grau-Rivera, Oriol; European Prevention of Alzheimer’s Disease (EPAD) Consortium (Oxford University Press, 2022)
    Sleep abnormalities are prevalent in Alzheimer's disease, with sleep quality already impaired at its preclinical stage. Epidemiological and experimental data point to sleep abnormalities contributing to the risk of Alzheimer's ...
  • CSF glial biomarkers YKL40 and sTREM2 are associated with longitudinal volume and diffusivity changes in cognitively unimpaired individuals
    Falcón, Carles; Monté-Rubio, Gemma C.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Sánchez Valle, Raquel; Rami, Lorena; Bosch, Beatriz; Haass, Christian; Gispert López, Juan Domingo; Molinuevo, José Luis (Elsevier, 2019)
    Cerebrospinal fluid (CSF) YKL40 and sTREM2 are astroglial and microglial activity biomarkers, respectively. We assessed whether CSF YKL40 and sTREM2 baseline levels are associated with longitudinal brain volume and diffusivity ...
  • Description of a European memory clinic cohort undergoing amyloid-PET: the AMYPAD diagnostic and patient management study
    Altomare, Daniele; Grau-Rivera, Oriol; Gispert López, Juan Domingo; Minguillón, Carolina; Frisoni, Giovanni B.; AMYPAD Consortium (Wiley, 2022)
    Introduction: AMYPAD Diagnostic and Patient Management Study (DPMS) aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Here we present participants' baseline features and discuss the ...
  • DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease
    Sala Vila, Aleix; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Grau-Rivera, Oriol; González de Echávarri, José Maria; Crous-Bou, Marta; Minguillón, Carolina; Fauria, Karine; Operto, Grégory; Falcón, Carles; Salvadó, Gemma; Cacciaglia, Raffaele; Ingala, Silvia; Barkhof, Frederik; Schröder, Helmut, 1958-; Scarmeas, Nikolaos; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (American Society for Nutrition, 2021)
    Background: The number of APOE-ε4 alleles is a major nonmodifiable risk factor for sporadic Alzheimer disease (AD). There is increasing evidence on the benefits of dietary DHA (22:6n-3) before the onset of AD symptoms, ...
  • Differences between plasma and cerebrospinal fluid glial fibrillary acidic protein levels across the alzheimer disease continuum
    Benedet, Andrea L.; Milà Alomà, Marta; Salvadó, Gemma; Shekari, Mahnaz; Operto, Gregory; Gispert López, Juan Domingo; Minguillón, Carolina; Molinuevo, José Luis; Suárez-Calvet, Marc; Translational Biomarkers in Aging and Dementia (TRIAD) study; ALFA Study; BioCogBank Paris Lariboisière cohort (American Medical Association, 2021)
    Importance: Glial fibrillary acidic protein (GFAP) is a marker of reactive astrogliosis that increases in the cerebrospinal fluid (CSF) and blood of individuals with Alzheimer disease (AD). However, it is not known whether ...