Durante el desarrollo del oído interno, Notch presenta dos modos de funcionamiento: inducción lateral, que se asocia con la especificación prosensorial, e inhibición lateral, asociada a la determinación de las células ...

The development of neural tissue starts with the activation of early neural genes such as the SoxB1 transcription factors, which are expressed in response to signaling molecules. Neural progenitors in the inner ear are ...

During inner ear development, Notch exhibits two modes of operation: lateral induction, which is associated with prosensory specification, and lateral inhibition, which is involved in hair cell determination. These mechanisms ...

Myc family members play crucial roles in regulating cell proliferation, size, and differentiation during organogenesis. Both N-myc and c-myc are expressed throughout inner ear development. To address their function in the ...

The proneural gene Atoh1 is crucial for the development of inner ear hair cells and it requires the function of the transcription factor Sox2 through yet unknown mechanisms. In the present work, we used the chicken embryo ...

The experiments described in this thesis report were aimed at studying the functions of Sox2 and Serrate1 during the development of the neurosensory elements of the inner ear. First, we have described the expression pattern ...

The vertebrate inner ear is the organ responsible for the senses of balance, acceleration and audition. Three cell types form the functional unit of the ear: hair cells, neurons and supporting cells. Atoh1 and Neurog1, two ...

Hearing loss is the most common sensorineural disorder, affecting over 5% of the population worldwide. Its most frequent cause is the loss of hair cells (HCs), the mechanosensory receptors of the cochlea. HCs transduce ...