Browsing by Author "Gebauer, Fátima"

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  • Torres Méndez, Antonio; Bonnal, Sophie; Marquez, Yamile; Roth, Jonathan; Iglesias, Marta; Permanyer, Jon; Almudí, Isabel; O'Hanlon, Dave; Guitart, Tanit; Soller, Matthias; Gingras, Anne-Claude; Gebauer, Fátima; Rentzsch, Fabian; Blencowe, Benjamin J.; Valcárcel, J. (Juan); Irimia, Manuel (Nature Research, 2019)
    The mechanisms by which entire programmes of gene regulation emerged during evolution are poorly understood. Neuronal microexons represent the most conserved class of alternative splicing in vertebrates, and are critical ...
  • Ju Lee, Hyun; Bartsch, Deniz; Xiao, Cally; Guerrero Jijon, Santiago Xavier; Ahuja, Gaurav; Schindler, Christina; Moresco, James J.; Yates, John R.; Gebauer, Fátima; Bazzi, Hisham; Dieterich, Christoph; Kurian, Leo; Vílchez, David (Nature Publishing Group, 2017)
    While the transcriptional network of human embryonic stem cells (hESCs) has been extensively studied, relatively little is known about how post-transcriptional modulations determine hESC function. RNA-binding proteins play ...
  • Kakumani, Pavan Kumar; Harvey, Louis-Mathieu; Houle, François; Guitart, Tanit; Gebauer, Fátima; Simard, Martin J. (Life Science Alliance, 2020)
    In animals, miRNAs are the most prevalent small non-coding RNA molecules controlling posttranscriptional gene regulation. The Argonaute proteins (AGO) mediate miRNA-guided gene silencing by recruiting multiple factors ...
  • Coll, Olga; Guitart, Tanit; Villalba, Ana; Papin, Catherine; Simonelig, Martine; Gebauer, Fátima (Cold Spring Harbor Laboratory Press (CSHL Press), 2018)
    Cytoplasmic polyadenylation is a widespread mechanism to regulate mRNA translation. In vertebrates, this process requires two sequence elements in target 3' UTRs: the U-rich cytoplasmic polyadenylation element and the ...
  • Militti, Cristina, 1982- (Universitat Pompeu Fabra, 2013-07-26)
    En Drosophila, el desequilibrio en cuanto al contenido de genes ligados al cromosoma X entre hembras (XX) y machos (XY) es corregido mediante la duplicación de la transcripción del único cromosoma X del macho. Este proceso, ...
  • Abaza, Irina (Universitat Pompeu Fabra, 2006-11-03)
    Dosage compensation is a mechanism that equalizes the expression of X-linked genes in those organisms in which males and females differ in the number of X chromosomes. In Drosophila melanogaster, dosage compensation is ...
  • Gebauer, Fátima; Hentze, Matthias W. (American Association for the Advancement of Science (AAAS), 2016)
    Comment on Comparative genetics. Systematic discovery of cap-independent translation sequences in human and viral genomes. [Science. 2016]
  • Szóstak, Emilia, 1984-; García Beyaert, Marina, 1983-; Guitart, Tanit; Graindorge, Antoine; Coll, Olga; Gebauer, Fátima (Oxford University Press, 2018)
    Translational repression of msl-2 mRNA in females of Drosophila melanogaster is an essential step in the regulation of X-chromosome dosage compensation. Repression is orchestrated by Sex-lethal (SXL), which binds to both ...
  • Nadimpalli, Hima Priyanka, 1988- (Universitat Pompeu Fabra, 2017-12-11)
    Cytoplasmic polyadenylation is a widespread mechanism to control mRNA translation. In vertebrates, this mechanism requires two sequence elements in the 3’ UTR of substrate mRNAs, the U-rich Cytoplasmic Polyadenylation ...
  • García Beyaert, Marina, 1983- (Universitat Pompeu Fabra, 2016-01-27)
    Regulation of msl2 translation is a key step in the modulation of X-chromosome dosage compensation. MSL2 is the limiting subunit of the dosage compensation complex, an assembly that promotes hyper-transcription of the ...
  • Szóstak, Emilia, 1984- (Universitat Pompeu Fabra, 2015-12-10)
    Unequal dosage of X-linked genes between males (XY) and females (XX) is balanced by dosage compensation mechanisms. In Drosophila melanogaster, the dosage compensation complex specifically induces a 2-fold hypertranscription ...
  • Inglés Ferrándiz, Marta, 1989- (Universitat Pompeu Fabra, 2018-12-14)
    In this thesis, we have been studying the role of UNR, and RNA-binding protein that regulates translation and/or stability of its targets. The functional relevance of UNR was studied in two different molecular contexts: ...
  • Ní Chárthaigh, Róisín-Ana (Universitat Pompeu Fabra, 2020-07-03)
    RNA-binding proteins are potent regulators of post-transcriptional gene expression. Among the repertoire of RNAs bound by a particular RNA-binding protein, networks of co-ordinately regulated RNAs, or ‘regulons’, are ...
  • Martínez-Useros, Javier; Georgiev Hristov, Tihomir; Fernández Aceñero, María Jesús; Borrero-Palacios, Aurea; Indacochea Cusirramos, Alberto; Guerrero Jijon, Santiago Xavier; Li, Weiyao; Cebrián, Arancha; del Pulgar, Teresa Gómez; Puime Otín, Alberto; Puerto Nevado, Laura del; Rodríguez Remírez, María; Pérez, Núria; Celdrán Uriarte, Ángel; Gebauer, Fátima; García-Foncillas, Jesús (Public Library of Science (PLoS), 2017)
    Pancreatic ductal adenocarcinoma is an aggressive form of pancreatic cancer and the fourth leading cause of cancer-related death. When possible, curative approaches are based on surgical resection, though not every patient ...
  • Wurth, Laurence; Papasaikas, Panagiotis; Olmeda, David; Bley, Nadine; Calvo, Guadalupe T.; Guerrero Jijon, Santiago Xavier; Cerezo-Wallis, Daniela; Martínez-Useros, Javier; García-Fernández, María; Hüttelmaier, Stefan; Soengas, María S.; Gebauer, Fátima (Elsevier, 2016)
    RNA binding proteins (RBPs) modulate cancer progression through poorly understood mechanisms. Here we show that the RBP UNR/CSDE1 is overexpressed in melanoma tumors and promotes invasion and metastasis. iCLIP sequencing, ...