Browsing by Author "Gebauer, Fátima"

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  • A novel protein domain in an ancestral splicing factor drove the evolution of neural microexons
    Torres Méndez, Antonio; Bonnal, Sophie; Marquez, Yamile; Roth, Jonathan; Iglesias, Marta; Permanyer, Jon; Almudi, Isabel; O'Hanlon, Dave; Guitart, Tanit; Soller, Matthias; Gingras, Anne-Claude; Gebauer, Fátima; Rentzsch, Fabian; Blencowe, Benjamin J.; Valcárcel, J. (Juan); Irimia, Manuel (Nature Research, 2019)
    The mechanisms by which entire programmes of gene regulation emerged during evolution are poorly understood. Neuronal microexons represent the most conserved class of alternative splicing in vertebrates, and are critical ...
  • A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells
    Ju Lee, Hyun; Bartsch, Deniz; Xiao, Cally; Guerrero Jijon, Santiago Xavier; Ahuja, Gaurav; Schindler, Christina; Moresco, James J.; Yates, John R.; Gebauer, Fátima; Bazzi, Hisham; Dieterich, Christoph; Kurian, Leo; Vílchez, David (Nature Publishing Group, 2017)
    While the transcriptional network of human embryonic stem cells (hESCs) has been extensively studied, relatively little is known about how post-transcriptional modulations determine hESC function. RNA-binding proteins play ...
  • Ataxin-2, Twenty-four, and Dicer-2 are components of a noncanonical cytoplasmic polyadenylation complex
    Nadimpalli, Hima Priyanka, 1988-; Guitart, Tanit; Coll, Olga; Gebauer, Fátima (Life Science Alliance, 2022)
    Cytoplasmic polyadenylation is a mechanism to promote mRNA translation in a wide variety of biological contexts. A canonical complex centered around the conserved RNA-binding protein family CPEB has been shown to be ...
  • Cold-inducible RNA binding protein promotes breast cancer cell malignancy by regulating Cystatin C levels
    Indacochea Cusirramos, Alberto; Guerrero Jijon, Santiago Xavier; Ureña, Macarena; Araujo, Ferrán; Coll, Olga; Lleonart, Matilde E.; Gebauer, Fátima (Cold Spring Harbor Laboratory Press (CSHL Press), 2021)
    Cold-inducible RNA binding protein (CIRBP) is a stress-responsive protein that promotes cancer development and inflammation. Critical to most CIRBP functions is its capacity to bind and posttranscriptionally modulate mRNA. ...
  • Coordinated post-transcriptional control of oncogene-induced senescence by UNR/CSDE1
    Avolio, Rosario; Inglés Ferrándiz, Marta, 1989-; Ciocia, Annagiulia; Coll, Olga; Bonnin, Sarah; Guitart, Tanit; Ribó Rubio, Anna; Gebauer, Fátima (Elsevier, 2022)
    Oncogene-induced senescence (OIS) is a form of stable cell-cycle arrest arising in response to oncogenic stimulation. OIS must be bypassed for transformation, but the mechanisms of OIS establishment and bypass remain poorly ...
  • CSDE1 controls gene expression through the miRNA-mediated decay machinery
    Kakumani, Pavan Kumar; Harvey, Louis-Mathieu; Houle, François; Guitart, Tanit; Gebauer, Fátima; Simard, Martin J. (Life Science Alliance, 2020)
    In animals, miRNAs are the most prevalent small non-coding RNA molecules controlling posttranscriptional gene regulation. The Argonaute proteins (AGO) mediate miRNA-guided gene silencing by recruiting multiple factors ...
  • Dicer-2 promotes mRNA activation through cytoplasmic polyadenylation
    Coll, Olga; Guitart, Tanit; Villalba, Ana; Papin, Catherine; Simonelig, Martine; Gebauer, Fátima (Cold Spring Harbor Laboratory Press (CSHL Press), 2018)
    Cytoplasmic polyadenylation is a widespread mechanism to regulate mRNA translation. In vertebrates, this process requires two sequence elements in target 3' UTRs: the U-rich cytoplasmic polyadenylation element and the ...
  • Drosophila UNR regulates dosage compensation through modulation of RNA-protein interactions
    Militti, Cristina, 1982- (Universitat Pompeu Fabra, 2013-07-26)
    En Drosophila, el desequilibrio en cuanto al contenido de genes ligados al cromosoma X entre hembras (XX) y machos (XY) es corregido mediante la duplicación de la transcripción del único cromosoma X del macho. Este proceso, ...
  • Drosophila UNR: a factor involved in the translational regulation of dosage compensation
    Abaza, Irina (Universitat Pompeu Fabra, 2006-11-03)
    Dosage compensation is a mechanism that equalizes the expression of X-linked genes in those organisms in which males and females differ in the number of X chromosomes. In Drosophila melanogaster, dosage compensation is ...
  • Genetics. IRES unplugged
    Gebauer, Fátima; Hentze, Matthias W. (American Association for the Advancement of Science (AAAS), 2016)
    Comment on Comparative genetics. Systematic discovery of cap-independent translation sequences in human and viral genomes. [Science. 2016]
  • Hrp48 and eIF3d contribute to msl-2 mRNA translational repression
    Szóstak, Emilia, 1984-; García Beyaert, Marina, 1983-; Guitart, Tanit; Graindorge, Antoine; Coll, Olga; Gebauer, Fátima (Oxford University Press, 2018)
    Translational repression of msl-2 mRNA in females of Drosophila melanogaster is an essential step in the regulation of X-chromosome dosage compensation. Repression is orchestrated by Sex-lethal (SXL), which binds to both ...
  • Insights into cytoplasmatic polyadenylation mediated by Drosophila Dicer-2
    Nadimpalli, Hima Priyanka (Universitat Pompeu Fabra, 2019-01-14)
    Cytoplasmic polyadenylation is a widespread mechanism to control mRNA translation. In vertebrates, this mechanism requires two sequence elements in the 3’ UTR of substrate mRNAs, the U-rich Cytoplasmic Polyadenylation ...
  • Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
    Mestre-Farràs, Neus; Guerrero Jijon, Santiago Xavier; Bley, Nadine; Rivero, Ezequiel; Coll, Olga; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Indacochea Cusirramos, Alberto; Casillas-Serra, Carlos; Järvelin, Aino I.; Oliva Miguel, Baldomero; Castello, Alfredo; Hüttelmaier, Stefan; Gebauer, Fátima (Oxford University Press, 2022)
    RNA-binding proteins (RBPs) have been relatively overlooked in cancer research despite their contribution to virtually every cancer hallmark. Here, we use RNA interactome capture (RIC) to characterize the melanoma RBPome ...
  • Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
    Gebauer, Fátima (Oxford University Press, 2022)
  • Molecular mechanisms of msl2 mRNA translational regulation
    García Beyaert, Marina, 1983- (Universitat Pompeu Fabra, 2018-11-21)
    Regulation of msl2 translation is a key step in the modulation of X-chromosome dosage compensation. MSL2 is the limiting subunit of the dosage compensation complex, an assembly that promotes hyper-transcription of the ...
  • New factors involved in translational regulation of Drosophila melanogaster msl2 mRNA
    Szóstak, Emilia, 1984- (Universitat Pompeu Fabra, 2015-12-10)
    Unequal dosage of X-linked genes between males (XY) and females (XX) is balanced by dosage compensation mechanisms. In Drosophila melanogaster, the dosage compensation complex specifically induces a 2-fold hypertranscription ...
  • Post-transcriptional regulation by UNR : insights into histone mRNA metabolism and cellular senescence
    Inglés Ferrándiz, Marta, 1989- (Universitat Pompeu Fabra, 2018-12-14)
    In this thesis, we have been studying the role of UNR, and RNA-binding protein that regulates translation and/or stability of its targets. The functional relevance of UNR was studied in two different molecular contexts: ...
  • Pseudo-RNA-binding domains mediate RNA structure specificity in upstream of N-Ras
    Hollmann, Nele Merret; Jagtap, Pravin Kumar Ankush; Masiewicz, Pawel; Guitart, Tanit; Simon, Bernd; Provaznik, Jan; Stein, Frank; Haberkant, Per; Sweetapple, Lara Jayne; Villacorta, Laura; Mooijman, Dylan; Benes, Vladimir; Savitski, Mikhail M.; Gebauer, Fátima; Hennig, Janosch (Elsevier, 2020)
    RNA-binding proteins (RBPs) commonly feature multiple RNA-binding domains (RBDs), which provide these proteins with a modular architecture. Accumulating evidence supports that RBP architectural modularity and adaptability ...
  • RNA-binding proteins in human genetic disease
    Gebauer, Fátima; Schwarzl, Thomas; Valcárcel, J. (Juan); Hentze, Matthias W. (Nature Research, 2020)
    RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their malfunction underlies the origin of many diseases. RBPs can recognize hundreds of transcripts and form extensive regulatory networks ...
  • Translational control by the RNA-binding protein CSDE1 : Insights into a stimulatory role in translation elongation
    Ní Chárthaigh, Róisín-Ana (Universitat Pompeu Fabra, 2020-07-03)
    RNA-binding proteins are potent regulators of post-transcriptional gene expression. Among the repertoire of RNAs bound by a particular RNA-binding protein, networks of co-ordinately regulated RNAs, or ‘regulons’, are ...