Browsing by Author "Gea Guiral, Joaquim"

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  • A pilot study on proteomic predictors of mortality in stable COPD
    Enríquez Rodríguez, César Jessé; Casadevall Fusté, Carme; Faner, Rosa; Pascual Guàrdia, Sergi, 1979-; Castro-Acosta, Ady Angélica; López Campos, José Luis; Peces-Barba Romero, Germán; Seijo, Luis; Caguana Vélez, Oswaldo Antonio; Monsó Molas, Eduard; Rodríguez Chiaradia, Diego Agustín; Barreiro Portela, Esther; Cosío, Borja G.; Agustí García-Navarro, Àlvar; Gea Guiral, Joaquim; BIOMEPOC group (MDPI, 2024)
    Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of global mortality. Despite clinical predictors (age, severity, comorbidities, etc.) being established, proteomics offers comprehensive biological ...
  • Actividad física y tolerancia al ejercicio en fibrosis pulmonar idiopática
    Badenes Bonet, Diana (2022-02-25)
    Introducción: Se comparó la oxigenoterapia de alto flujo (OAF) vs. oxigenoterapia convencional (OC) en el tiempo de resistencia (Tlim) de pacientes con FPI y desaturación al esfuerzo. Se estudiaron los predictores de ...
  • Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients
    Pascual Guàrdia, Sergi, 1979-; Ataya Fernández, Michelle, 1993-; Ramírez Martínez, Isabel; Yélamos López, José; Chalela Rengifo, Roberto José, 1985-; Bellido, Salomé; López-Botet, M. (Miguel); Gea Guiral, Joaquim (BioMed Central, 2020)
    Abstract: Chronic obstructive pulmonary disease (COPD) is a chronic and often progressive disorder with a heterogeneous presentation and frequent systemic manifestations. Several aspects like persistence in smoking habit, ...
  • Averroes, rationalism and systematization in medicine
    Gea Guiral, Joaquim (Elsevier, 2020)
  • Beneficial effects of resveratrol in mouse gastrocnemius: a hint to muscle phenotype and proteolysis
    Mañas García, Laura, 1991-; Denhard, Charlotte; Mateu de Antonio, Francisco Javier; Duran Jordà, Xavier, 1974-; Gea Guiral, Joaquim; Barreiro Portela, Esther (MDPI, 2021)
    We hypothesized that the phenolic compound resveratrol mitigates muscle protein degradation and loss and improves muscle fiber cross-sectional area (CSA) in gastrocnemius of mice exposed to unloading (7dI). In gastrocnemius ...
  • Bispectral index in hypercapnic encephalopathy associated with COPD exacerbation: a pilot study
    Chalela Rengifo, Roberto José, 1985-; Gallart Gallego, Lluís; Pascual Guàrdia, Sergi, 1979-; Sancho Muñoz, Antonio; Gea Guiral, Joaquim; Orozco Levi, Mauricio (DOVE Medical Press, 2018)
    Background: Hypercapnic encephalopathy is relatively frequent in severe exacerbations of COPD (ECOPDs), with its intensity usually being evaluated through clinical scales. Bispectral index (BIS) is a relatively new technique, ...
  • Caracterización de los pacientes hospitalizados por primera vez por exacerbación de la Enfermedad Pulmonar Obstructiva Crónica
    Balcells Vilarnau, Eva (Universitat Pompeu Fabra, 2016-02-11)
    Introducción: Hay poca información sobre la primera hospitalización por exacerbación de la Enfermedad Pulmonar Obstructiva Crónica (EPOC), a pesar de ser un evento importante en la historia natural de esta enfermedad. El ...
  • Caracterización del fenotipo muscular en la EPOC y sepsis en pacientes : estructura fibrilar, inflamación, estrés oxidativo y regeneración
    Pascual, Sergi (Universitat Pompeu Fabra, 2015-12-10)
    La inflamación y el estrés oxidativo son mecanismos moleculares que contribuyen al daño y a la disfunción muscular. Existen procesos crónicos con fenómenos inflamatorios de bajo grado pero de larga duración (EPOC, con o ...
  • Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation
    Balcells Vilarnau, Eva, 1967-; Gimeno Santos, Elena, 1980-; De Batlle, Jordi; Ramon, Maria Antonia; Rodríguez, Esther; Benet, Marta; Ferrer, Jaume; Farrero, Eva; Ferrer, Antoni-Lluc, 1942-; Guerra, Stefano; Ferrer, Jaume; Sauleda Roig, Jaume; Barberà, Joan Albert; Agustí García-Navarro, Àlvar; Rodriguez, Robert, 1968-; Gea Guiral, Joaquim; Antó i Boqué, Josep Maria; García Aymerich, Judith (BioMed Central, 2015)
    Background. Under-diagnosis of COPD is an important unmet medical need. We investigated the characteristics and prognosis of hospitalised patients with undiagnosed COPD./nMethods. The PAC-COPD cohort included 342 COPD ...
  • Characteristics of patients admitted for the first time for COPD exacerbation
    Balcells Vilarnau, Eva, 1967-; Antó i Boqué, Josep Maria; Gea Guiral, Joaquim; Gómez, Federico P.; Rodríguez, Esther; Marin, Alicia; Ferrer, Antoni-Lluc, 1942-; De Batlle, Jordi; Farrero, Eva; Benet, Marta; Orozco Levi, Mauricio; Ferrer, Jaume; Agustí García-Navarro, Àlvar; Gáldiz, Juan B.; Belda, José; García Aymerich, Judith (Elsevier, 2009)
    BACKGROUND: This study describes the characteristics of a large sample of patients hospitalised for the first time for a chronic obstructive pulmonary disease (COPD) exacerbation. METHODS: All subjects first admitted for ...
  • COPD: systemic proteomic profiles in frequent and infrequent exacerbators
    Enríquez Rodríguez, César Jessé; Casadevall Fusté, Carme; Faner, Rosa; Castro Costa, Ady; Pascual Guàrdia, Sergi, 1979-; Seijó Maceiras, Luis; López Campos, José Luis; Peces-Barba Romero, Germán; Monsó Molas, Eduard; Barreiro Portela, Esther; Cosío, Borja G.; Agustí García-Navarro, Àlvar; Gea Guiral, Joaquim; BIOMEPOC group (European Respiratory Society, 2024)
    Background: Some patients with COPD suffer frequent exacerbations (FE). We hypothesised that their systemic proteomic profile would be different from that of non-frequent exacerbators (NFE). The objective of the present ...
  • Deficient muscle regeneration potential in sarcopenic COPD patients: Role of satellite cells
    Sancho Muñoz, Antonio; Guitart, Maria; Rodríguez, Diego; Gea Guiral, Joaquim; Martínez-Llorens, Juana Mª; Barreiro Portela, Esther (Wiley, 2021)
    Sarcopenia is a major comorbidity in chronic obstructive pulmonary (COPD). Whether deficient muscle repair mechanisms and regeneration exist in the vastus lateralis (VL) of sarcopenic COPD remains debatable. In the VL of ...
  • Determinants of change in physical activity during moderate-to-severe COPD exacerbation
    Esteban, Cristóbal; Quintana, José María; García Gutiérrez, Susana; Antón Ladislao, Ane; González, Nerea; Baré, Marisa; Fernández de Larrea-Baz, Nerea; Rivas Ruiz, Francisco; Gea Guiral, Joaquim; IRYSS-COPD group (Dove Medical Press, 2016)
    BACKGROUND: Data are scarce on patient physical activity (PA) level during exacerbations of chronic obstructive pulmonary disease (eCOPD). The objective of the study was to evaluate the level and determinants of change in ...
  • Differences in acoustic features of cough by pneumonia severity in patients with COVID-19: a cross-sectional study
    Davidson, Clare; Caguana Vélez, Oswaldo Antonio; Lozano-García, Manuel; Guevara, Mariela Arita; Estrada-Petrocelli, Luis; Ferrer-Lluis, Ignasi; Castillo-Escario, Yolanda; Ausín Herrero, Pilar, 1974-; Gea Guiral, Joaquim; Jané, Raimon (European Respiratory Society, 2023)
    Background: Acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) is characterised by heterogeneous levels of disease severity. It is not necessarily apparent whether a patient will develop severe disease or not. ...
  • Differences in micro-RNA expression profile between vastus lateralis samples and myotubes in COPD cachexia
    Barreiro Portela, Esther; Sancho Muñoz, Antonio; Puig Vilanova, Ester, 1987-; Salazar Degracia, Anna; Pascual Guàrdia, Sergi, 1979-; Casadevall Fusté, Carme; Gea Guiral, Joaquim (American Physiological Society, 2019)
    Quadriceps muscle weakness and wasting are common comorbidities in chronic obstructive pulmonary disease (COPD). Micro-RNA expression upregulation may favor muscle mass growth and differentiation. We hypothesized that the ...
  • Disfunció Muscular en Malalts amb malaltia Pulmonar Obstructiva Crònica (MPOC)
    Coronell Coronell, Carlos Gustavo (Universitat Pompeu Fabra, 2011-04-12)
    La Enfermedad Pulmonar Obstructiva Crónica (EPOC), presenta signos y síntomas sistémicos que se han venido explorando desde hace algún tiempo. La presente Tesis Doctoral estudia la disfunción que presentan los músculos ...
  • Do epigenetic events take place in the vastus lateralis of patients with mild chronic obstructive pulmonary disease?
    Puig Vilanova, Ester, 1987-; Ausín Herrero, Pilar, 1974-; Martínez-Llorens, Juana Mª; Gea Guiral, Joaquim; Barreiro Portela, Esther (Public Library of Science (PLoS), 2014)
    Muscle dysfunction is a major comorbidity in Chronic Obstructive Pulmonary Disease (COPD). Several biological mechanisms including epigenetic events regulate muscle mass and function in models of muscle atrophy. Investigations ...
  • EGFR and KRAS mutations in lung parenchyma of subjects with EGFR/KRAS wild-type lung adenocarcinoma
    Chalela Rengifo, Roberto José, 1985-; González-García, José Gregorio; Khilzi, Karys; Curull Serrano, Víctor; Sánchez Font, Albert; Longarón Rozalen, Raquel; Rodrigo Calvo, Maria Teresa; Martín-Ontiyuelo, Clara; Gea Guiral, Joaquim; Bellosillo Paricio, Beatriz (Frontiers, 2021)
    The acquisition of driver mutations in non-tumoral cells appears to be very important during the carcinogenesis of adenocarcinoma (ADC). Recent studies suggest that cancer-related mutations may not necessarily be present ...
  • EGFR and KRAS mutations in the non-tumoral lung. Prognosis in patients with adenocarcinoma
    Chalela Rengifo, Roberto José, 1985-; Bellosillo Paricio, Beatriz; Curull Serrano, Víctor; Longarón Rozalen, Raquel; Pascual Guàrdia, Sergi, 1979-; Badenes Bonet, Diana, 1987-; Arriola Aperribay, Edurne; Sánchez-Font, Albert; Pijuan Andujar, Lara; Gea Guiral, Joaquim (MDPI, 2019)
    Tumor recurrence is frequent and survival rates remain extremely low in lung adenocarcinoma (ADC). We hypothesize that carcinogenic factors will promote loco-regional modifications not only in the future tumor, but throughout ...
  • Endoplasmic reticulum stress and unfolded protein response in diaphragm muscle dysfunction of patients with stable chronic obstructive pulmonary disease
    Barreiro Portela, Esther; Salazar Degracia, Anna; Sancho Muñoz, Antonio; Aguiló Espases, Rafael; Rodríguez-Fuster, Alberto; Gea Guiral, Joaquim (American Physiological Society, 2019)
    Respiratory muscle dysfunction is common in patients with chronic obstructive pulmonary disease (COPD). Chronic contractile activity induces endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in animals ...

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