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Browsing by Author "Garriga-Canut, Mireia"

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Deimmunization for gene therapy: host matching of synthetic zinc finger constructs enables long-term mutant Huntingtin repression in mice

Agustín Pavón, Carmen; Mielcarek, Michael; Garriga-Canut, Mireia; Isalan, Mark (BioMed Central, 2016)

BACKGROUND: Synthetic zinc finger (ZF) proteins can be targeted to desired DNA sequences and are useful tools for gene therapy. We recently developed a ZF transcription repressor (ZF-KOX1) able to bind to expanded DNA ...
Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins

Lang, Benjamin; Yang, Jae-Seong; Garriga-Canut, Mireia; Speroni, Silvia; Aschern, Moritz; Gili, Maria; Hoffmann, Tobias, 1990-; Tartaglia, Gian Gaetano; Maurer, Sebastian (Oxford University Press, 2021)

RNA-binding proteins (RBPs) are crucial factors of post-transcriptional gene regulation and their modes of action are intensely investigated. At the center of attention are RNA motifs that guide where RBPs bind. However, ...
rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions

Yang, Jae-Seong; Garriga-Canut, Mireia; Link, Nele; Carolis, Carlo; Broadbent, Katrina; Beltran-Sastre, Violeta; Serrano Pubull, Luis, 1982-; Maurer, Sebastian (Nature Research, 2018)

Knowing which proteins and RNAs directly interact is essential for understanding cellular mechanisms. Unfortunately, discovering such interactions is costly and often unreliable. To overcome these limitations, we developed ...

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Browsing by Author "Garriga-Canut, Mireia"

Browsing by Author "Garriga-Canut, Mireia"

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