Browsing by Author "Garcia-Elias Heras, Anna"

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  • Aging impairs reverse remodeling and recovery of ventricular function after isoproterenol-induced cardiomyopathy
    Yáñez Bisbe, Laia, 1993-; Garcia-Elias Heras, Anna; Tajes Orduña, Marta; Almendros, Isaac; Rodríguez-Sinovas, Antonio; Inserte, Javier; Ruiz-Meana, Marisol; Farré, Ramon; Farré López, Núria; Benito Villabriga, Begoña (MDPI, 2022)
    Information about heart failure with reduced ejection fraction (HFrEF) in women and the potential effects of aging in the female heart is scarce. We investigated the vulnerability to develop HFrEF in female elderly mice ...
  • Atrial fibrillation in heart failure is associated with high levels of circulating microRNA-199a-5p and 22-5p and a defective regulation of intracellular calcium and cell-to-cell communication
    Garcia-Elias Heras, Anna; Tajes Orduña, Marta; Yañez Bisbe, Laia; Enjuanes Grau, Cristina; Comín Colet, Josep; Serra, Selma A.; Fernández-Fernández, José Manuel, 1967-; Aguilar-Agon, Kathryn W.; Reilly, Svetlana; Martí Almor, Julio; Benito Villabriga, Begoña (MDPI, 2021)
    MicroRNAs (miRNAs) participate in atrial remodeling and atrial fibrillation (AF) promotion. We determined the circulating miRNA profile in patients with AF and heart failure with reduced ejection fraction (HFrEF), and its ...
  • Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome
    Navarro Romero, Alba, 1990-; Galera López, Lorena, 1993-; Ortiz Romero, Paula, 1994-; Llorente-Ovejero, Alberto; Los Reyes-Ramírez, Lucía de; Bengoetxea de Tena, Iker; Garcia-Elias Heras, Anna; Mas-Stachurska, Aleksandra; Reixachs i Solé, Marina; Pastor, Antonio; Torre Fornell, Rafael de la; Maldonado, Rafael, 1961-; Benito Villabriga, Begoña; Eyras Jiménez, Eduardo; Rodríguez-Puertas, Rafael; Campuzano Uceda, María Victoria; Ozaita Mintegui, Andrés, 1969- (eLife, 2022)
    Williams-Beuren syndrome (WBS) is a rare genetic multisystemic disorder characterized by mild-to-moderate intellectual disability and hypersocial phenotype, while the most life-threatening features are cardiovascular ...
  • Defining quantification methods and optimizing protocols for microarray hybridization of circulating microRNAs
    Garcia-Elias Heras, Anna; Alloza, Leonor; Puigdecanet Riubugent, Eulàlia; Nonell Mazelón, Lara; Tajes Orduña, Marta; Curado, Joao; Enjuanes Grau, Cristina; Díaz, Oscar; Bruguera-Cortada, Jordi; Martí-Almor, Julio; Comín Colet, Josep; Benito Villabriga, Begoña (Nature Publishing Group, 2017)
    MicroRNAs (miRNAs) have emerged as promising biomarkers of disease. Their potential use in clinical practice requires standardized protocols with very low miRNA concentrations, particularly in plasma samples. Here we tested ...
  • Ion Channel Disorders and Sudden Cardiac Death
    Garcia-Elias Heras, Anna; Benito Villabriga, Begoña (MDPI, 2018)
    Long QT syndrome, short QT syndrome, Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia are inherited primary electrical disorders that predispose to sudden cardiac death in the absence of structural ...
  • IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid
    Fernandes, Jacqueline; Lorenzo, Ivan M.; Andrade, Yaniré N.; Garcia-Elias Heras, Anna; Serra Pascual, Selma A., 1981-; Fernández-Fernández, José Manuel, 1967-; Valverde, M. A. (Miguel Ángel), 1963- (Rockefeller University Press, 2008)
    Mechanical and osmotic sensitivity of the transient receptor potential vanilloid 4 (TRPV4) channel depends on phospholipase A(2) (PLA(2)) activation and the subsequent production of the arachidonic acid metabolites, ...
  • Molecular determinants of TRPV4 channel regulation
    Garcia-Elias Heras, Anna (Universitat Pompeu Fabra, 2011-06-30)
    TRPV4 is a non-selective cation channel with a wide expression and multiple cellular and systemic functions. Described initially as an osmosensor, it can also be activated by temperature and cell swelling. Due to this ...
  • Role of TRPV4 channels in adverse cardiac remodelling
    Yáñez Bisbe, Laia, 1993- (2022-03-09)
    Els mecanismes que determinen el desenvolupament de remodelat cardíac, tant en la seva forma adversa (característica de la insuficiència cardíaca), com adaptativa (induïda per exercici), no es coneixen en detall. Els ...