Browsing by Author "García-Giralt, Natalia"

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  • An abnormal inflammatory pattern associated with long-term non-progression of HIV infection impacts negatively on bone quality
    Soldado-Folgado, Jade; Chillarón Jordan, Juan José; Cañas-Ruano, Esperanza; Arrieta Aldea, Itziar; González Mena, Alicia; Blasco-Hernando, Fabiola; Knobel Freud, Hernando; García-Giralt, Natalia; Güerri Fernández, Roberto (MDPI, 2022)
    Long-term non-progressors (LTNPs) are HIV-infected individuals (HIV+) whose viral replication is controlled. However, these individuals experience complications associated with HIV, among them, bone remodeling impairment. ...
  • Calcifediol treatment and COVID-19-related outcomes
    Nogués Solan, Francesc Xavier; Ovejero Crespo, Diana; Pineda-Moncusí, Marta; Bouillon, Roger; Arenas Jiménez, María Dolores; Pascual Santos, Julio; Ribes, Anna; Guerri-Fernandez, Robert; Villar García, Judit; Rial, Abora; Gimenez-Argente, Carme; Cos, Maria Lourdes; Rodriguez-Morera, Jaime; Campodarve, Isabel; Quesada-Gómez, J.M.; García-Giralt, Natalia (Oxford University Press, 2021)
    Context: COVID-19 is a major health problem because of saturation of intensive care units (ICU) and mortality. Vitamin D has emerged as a potential treatment able to reduce the disease severity. Objective: This work aims ...
  • Circulating miR-103a-3p and miR-660-5p are associated with bone parameters in patients with controlled acromegaly
    Valassi, Elena; García-Giralt, Natalia; Malouf Sierra, Jorge; Crespo, Iris; Llauger, Jaume; Diez-Perez, Adolfo; Webb, Susan M. (BioScientifica, 2019)
    Background Biochemical control of GH/IGF-I excess in acromegaly (ACRO) is associated with persistent impairment of trabecular microstructure leading to increased risk of vertebral fractures. Circulating miRNAs modulate the ...
  • Common and rare variants of WNT16, DKK1 and SOST and their relationship with bone mineral density
    Martínez-Gil, Núria; Roca Ayats, Neus; Monistrol-Mula, Anna; García-Giralt, Natalia; Diez-Perez, Adolfo; Nogués Solan, Francesc Xavier; Mellibovsky, Leonardo; Grinberg, Daniel; Balcells, Susana (Nature Research, 2018)
    Numerous GWAS and candidate gene studies have highlighted the role of the Wnt pathway in bone biology. Our objective has been to study in detail the allelic architecture of three Wnt pathway genes: WNT16, DKK1 and SOST, ...
  • Functional characterization of a GGPPS variant identified in atypical femoral fracture patients and delineation of the role of GGPPS in bone-relevant cell types
    Roca Ayats, Neus; Ng, Pei Ying; García-Giralt, Natalia; Falcó-Mascaró, Maite; Cozar, Mónica; Abril Ferrando, Josep Francesc; Quesada-Gómez, J.M.; Prieto-Alhambra, Daniel; Nogués Solan, Francesc Xavier; Dunford, James E.; Russell, R. Graham; Baron, Roland; Grinberg, Daniel; Balcells, Susana; Díez Pérez, Adolfo (Wiley, 2018)
    Atypical femoral fractures (AFFs) are a rare but potentially devastating event, often but not always linked to bisphosphonate (BP) therapy. The pathogenic mechanisms underlying AFFs remain obscure, and there are no tests ...
  • In vitro characterization of in situ alloyed Ti6Al4V(ELI)-3 at.% Cu obtained by laser powder bed fusion
    Martín Vilardell, Anna; Krakhmalev, Pavel; Yadroitsava, Ina; Yadroitsev, Igor; García-Giralt, Natalia (MDPI, 2021)
    The intensive cytotoxicity of pure copper is effectively kills bacteria, but it can compromise cellular behavior, so a rational balance must be found for Cu-loaded implants. In the present study, the individual and combined ...
  • Individuals with higher CD4/CD8 ratio exhibit increased risk of acute respiratory distress syndrome and in-hospital mortality during acute SARS-CoV-2 infection
    Pascual-Dapena, Ana; Chillarón Jordan, Juan José; Llauradó Cabot, Gemma; Arnau-Barrés, Isabel; Flores-Le-Roux, Juana Antonia; López Montesinos, Inmaculada; Sorli Redó, M. Luisa; Martínez-Pérez, Juan Luis; Gómez-Zorrilla, Silvia; Du, Juan; García-Giralt, Natalia; Güerri Fernández, Roberto (Frontiers, 2022)
    Background: CD4/CD8 ratio has been used as a quantitative prognostic risk factor in patients with viral infections. This study aims to assess the association between in-hospital mortality and at admission CD4/CD8 ratio ...
  • Low zinc levels at admission associates with poor clinical outcomes in SARS-CoV-2 infection
    Vogel-González, Marina; Talló Parra, Marc, 1992-; Herrera-Fernández, Víctor; Pérez Vilaró, Gemma, 1985-; Chillón, Miguel; Nogués Solan, Francesc Xavier; Gómez-Zorrilla, Silvia; López Montesinos, Inmaculada; Arnau-Barrés, Isabel; Sorli Redó, M. Luisa; Horcajada Gallego, Juan Pablo; García-Giralt, Natalia; Pascual Santos, Julio; Díez Antón, Juana, 1962-; Vicente García, Rubén, 1978-; Güerri Fernández, Roberto (MDPI, 2021)
    Background: Zinc is an essential micronutrient that impacts host-pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc ...
  • Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adults
    Arnau-Barrés, Isabel; Pascual-Dapena, Ana; López Montesinos, Inmaculada; Gómez-Zorrilla, Silvia; Sorli Redó, M. Luisa; Herrero, Marta; Nogués Solan, Francesc Xavier; Montero, Milagros; Vázquez Ibar, Olga; García-Giralt, Natalia; Miralles Basseda, Ramon; Güerri Fernández, Roberto (MDPI, 2021)
    Myocardial involvement during SARS-CoV-2 infection has been reported in many prior publications. We aim to study the prevalence and the clinical implications of acute myocardial injury (MIN) during SARS-CoV-2 infection, ...
  • Response to letter to the editor from Viola et al: "calcifediol treatment and COVID-19-related outcomes"
    Nogués Solan, Francesc Xavier; Quesada-Gómez, J.M.; García-Giralt, Natalia (Oxford University Press, 2021)
  • Severe hypoalbuminemia at admission is strongly associated with worse prognosis in older adults with SARS-CoV-2 infection
    Arnau-Barrés, Isabel; Pascual-Dapena, Ana; López Montesinos, Inmaculada; Gómez-Zorrilla, Silvia; Sorli Redó, M. Luisa; Herrero, Marta; Nogués Solan, Francesc Xavier; Navarro-Valls, Claudia; Ibarra-Rubio, Beatriz; Canchucaja, Lizzeth; Da Costa, Elizabeth; Blasco-Hernando, Fabiola; Cruz, Juany; Vázquez Ibar, Olga; Miralles Basseda, Ramon; García-Giralt, Natalia; Güerri Fernández, Roberto (MDPI, 2021)
    Serum albumin levels have been associated with prognosis in several conditions among older adults. The aim of this study is to assess the prognostic value in mortality of serum albumin in older adults with SARS-CoV-2 ...