Browsing by Author "García-García, Javier, 1982-"

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  • Bonet Martínez, Jaume, 1982-; Planas Iglesias, Joan, 1980-; García-García, Javier, 1982-; Marín López, Manuel Alejandro, 1987-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2014)
    The function of a protein is determined by its three-dimensional structure, which is formed by regular (i.e. β-strands and α-helices) and non-periodic structural units such as loops. Compared to regular structural elements, ...
  • García-García, Javier, 1982-; Güney, Emre, 1983-; Aragüés Peleato, Ramón; Planas Iglesias, Joan, 1980-; Oliva Miguel, Baldomero (BioMed Central, 2010)
    Background: The analysis and usage of biological data is hindered by the spread of information across multiple repositories and the difficulties posed by different nomenclature systems and storage formats. In particular, ...
  • García-García, Javier, 1982-; Schleker, Sylvia; Klein-Seetharaman, Judith; Oliva Miguel, Baldomero (Oxford University Press, 2012)
    Protein-protein interactions (PPIs) play a crucial role in biology, and high-throughput experiments have greatly increased the coverage of known interactions. Still, identification of complete inter- and intraspecies ...
  • Sieberts, Solveig K.; García-García, Javier, 1982-; Aguilar, Daniel; Anton, Bernat; Bonet Martínez, Jaume, 1982-; Fornés Crespo, Oriol, 1983-; Marín López, Manuel Alejandro, 1987-; Planas Iglesias, Joan, 1980-; Poglayen, Daniel, 1984-; Oliva Miguel, Baldomero; Mangravite, Lara M. (Nature Publishing Group, 2016)
    Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widelyused to reduce disease progression, treatment fails inBone-third of patients. No biomarkercurrently exists that identifies non-responders ...
  • Piñero González, Janet, 1977-; Bravo Serrano, Àlex, 1984-; Queralt Rosinach, Núria; Gutiérrez Sacristán, Alba; Déu Pons, Jordi; Centeno, Emilio; García-García, Javier, 1982-; Sanz, Ferran; Furlong, Laura I., 1971- (Oxford University Press, 2017)
    The information about the genetic basis of human diseases lies at the heart of precision medicine and drug discovery. However, to realize its full potential to support these goals, several problems, such as fragmentation, ...
  • Rubio Pérez, Carlota, 1990-; Güney, Emre, 1983-; Aguilar, Daniel; Piñero González, Janet, 1977-; García-García, Javier, 1982-; Iadarola, Barbara; Sanz, Ferran; Fernández Fuentes, Narcís; Furlong, Laura I., 1971-; Oliva Miguel, Baldomero (Nature Publishing Group, 2017)
    Understanding relationships between diseases, such as comorbidities, has important socio-economic implications, ranging from clinical study design to health care planning. Most studies characterize disease comorbidity using ...
  • Picón-Pagès, Pol; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Garcia-Buendia, Joan; Gutierrez, Daniela; Valle, Javier; Gómez-Casuso, Carmen E.S.; Sidelkivska, Valeriya; Alvarez, Alejandra; Perálvarez Marín, Alex; Suades, Albert; Fernàndez Busquets, Xavier; Andreu Martínez, David; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Elsevier, 2019)
    Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate ...
  • Hill, Steven M.; Anton, Bernat; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Oliva Miguel, Baldomero; Planas Iglesias, Joan, 1980-; Poglayen, Daniel, 1984-; Mukherjee, Sach; The HPN-DREAM Consortium (Nature Publishing Group, 2016)
    It remains unclear whether causal, rather than merely correlational, relationships in molecular networks can be inferred in complex biological settings. Here we describe the HPN-DREAM network inference challenge, which ...
  • Marín López, Manuel Alejandro, 1987-; Planas Iglesias, Joan, 1980-; Aguirre Plans, Joaquim, 1993-; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2018)
    MOTIVATION: The characterization of the protein-protein association mechanisms is crucial to understanding how biological processes occur. It has been previously shown that the early formation of non-specific encounters ...
  • Schleker, Sylvia; García-García, Javier, 1982-; Klein-Seetharaman, Judith; Oliva Miguel, Baldomero (Wiley-VCH Verlag, 2012)
    Salmonellosis caused by Salmonella bacteria is a food-borne disease and a worldwide health threat causing millions of infections and thousands of deaths every year. This pathogen infects an unusually broad range of host ...
  • Kueffner, Robert; García-García, Javier, 1982-; Stolovitzky, Gustavo (Nature Research, 2019)
    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease where substantial heterogeneity in clinical presentation urgently requires a better stratification of patients for the development of drug trials and ...

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