Browsing by Author "García de Herreros, Antonio"

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  • A p120-catenin-CK1epsilon complex regulates Wnt signaling
    Casagolda, David; Valle Pérez, Beatriz del; Valls, Gabriela; Lugilde, Ero; Vinyoles, Meritxell; Casado Vela, Juan; Solanas, Guiomar; Batlle Gómez, Eduard; Reynolds, Albert B.; Casal, José Ignacio; García de Herreros, Antonio; Duñach, Mireia (Company of Biologists, 2010)
    p120-catenin is an E-cadherin-associated protein that modulates E-cadherin function and stability. We describe here that p120-catenin is required for Wnt pathway signaling. p120-catenin binds and is phosphorylated by CK1ε ...
  • A proteomic analysis reveals that Snail regulates the expression of the nuclear orphan receptor Nuclear Receptor Subfamily 2 Group F Member 6 (Nr2f6) and interleukin 17 (IL-17) to inhibit adipocyte differentiation
    Peláez García, Alberto; Barderas, Rodrigo; Batlle Gómez, Raquel; Viñas Castells, Rosa, 1985-; Bartolome, Rubén A.; Torres, Sofía; Mendes, Marta; López Lucendo, María; Mazzolini, Rocco; Bonilla, Félix; García de Herreros, Antonio; Casal, José Ignacio (American Society for Biochemistry and Molecular Biology (ASBMB), 2015)
    Adipogenesis requires a differentiation program driven by multiple transcription factors, where PPARγ and C/EBPα play a central role. Recent findings indicate that Snail inhibits adipocyte differentiation in 3T3-L1 and ...
  • A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition
    Vincent, Theresa; Neve, Etienne P.A.; Johnson, Jill R.; Kukalev, Alexander; Rojo, Federico; Albanell Mestres, Joan; Pietras, Kristian; Virtanen, Ismo; Philipson, Lennart; Leopold, Philip L.; Crystal, Ronald G.; García de Herreros, Antonio; Moustakas, Aristidis; Petterson, Ralf F.; Fuxe, Jonas (Nature Research, 2009)
    Epithelial-mesenchymal transition (EMT) is essential for organogenesis and is triggered during carcinoma progression to an invasive state. Transforming growth factor-beta (TGF-beta) cooperates with signalling pathways, ...
  • Activation of CK1ɛ by PP2A/PR61ɛ is required for the initiation of Wnt signaling
    Vinyoles, Meritxell; Valle Pérez, Beatriz del; Curto, Josué; Padilla, Mary; Villarroel, Aida; Yang, J.Y.; García de Herreros, Antonio; Duñach, Mireia (Springer Nature, 2017)
    Canonical Wnt signaling induces the stabilization of β-catenin, its translocation to the nucleus and the activation of target promoters. This pathway is initiated by the binding of Wnt ligands to the Frizzled receptor, the ...
  • Analyzing the role of activated fibroblasts in the activation of macrophages
    Bruch Oms, Marina (Universitat Pompeu Fabra, 2022-12-15)
    Tumors are complex masses composed by multiple cell types, such as cancer associated fibroblasts (CAFs) and macrophages, that interact with each other promoting the tumor progression. Snail1 is a transcription factor ...
  • Analyzing the role of cancer-associated adipocytes in brest tumor metastasis
    Garrido Jiménez, Laura (Universitat Pompeu Fabra, 2024-11-08)
    In breast cancer, the tumor microenvironment includes adipocytes and fibroblasts. When in contact with breast tumor cells, adipocytes undergo lipolysis and dedifferentiation. This thesis demonstrates that cancer-associated ...
  • Analyzing the role of cancer-associated fibroblast activation on macrophage polarization
    Bruch Oms, Marina; Olivera-Salguero, Rubén, 1991-; Mazzolini, Rocco; Valle Pérez, Beatriz del; Mayo González, Paula; Beteta, Ángel; Peña Arranz, Raúl, 1976-; García de Herreros, Antonio (Wiley, 2023)
    Snail1 is a transcriptional factor required for cancer-associated fibroblast (CAF) activation, and mainly detected in CAFs in human tumors. In the mouse mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT) model ...
  • Bioactivity descriptors for uncharacterized chemical compounds
    Bertoni, Martino; Duran-Frigola, Miquel, 1985-; Badia-I-Mompel, Pau; Pauls, Eduardo; Orozco Ruiz, Modesto; Guitart Pla, Oriol; Alcalde, Víctor; Diaz, Víctor M.; Berenguer-Llergo, Antonio; Brun-Heath, Isabelle; Villegas, Núria; García de Herreros, Antonio; Aloy, Patrick, 1972- (Nature Research, 2021)
    Chemical descriptors encode the physicochemical and structural properties of small molecules, and they are at the core of chemoinformatics. The broad release of bioactivity data has prompted enriched representations of ...
  • Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients
    Herrera, Mercedes; Herrera, Alberto; Domínguez, Gemma; Silva, Javier; García, Vanesa; García, Jose M.; Gómez, Irene; Soldevilla, Beatriz; Muñoz, Concepción; Provencio, Mariano; Campos Martin, Yolanda; García de Herreros, Antonio; Casal, José Ignacio; Bonilla, Félix; Peña, Cristina (Japanese Cancer Association, 2013)
    Tumor epithelial cells within a tumor coexist with a complex microenvironment in which a variety of interactions between its various components determine the behavior of the primary tumors. Cancer-associated fibroblasts ...
  • Cannabinoids receptor type 2, CB2, expression correlates with human colon cancer progression and predicts patient survival
    Martínez-Martínez, Esther; Gómez, Irene; Martín, Paloma; Sánchez, Antonio J.; Román, Laura; Tejerina, Eva; Bonilla, Félix; García Merino, Antonio; García de Herreros, Antonio; Provencio, Mariano; García, Jose M. (Impact Journals, 2015)
    Many studies have demonstrated that the endocannabinoid system (ECS) is altered in different tumor types, including colon cancer. However, little is known about the role of the ECS in tumor progression. Here we report the ...
  • Characterization of endothelial to mesenchymal transition induced by Notch
    Frías Hernández, Àlex (Universitat Pompeu Fabra, 2017-04-10)
    Notch activation in aortic endothelial cells (ECs) takes place at embryonic stages during cardiac valve formation and induces an endothelial-to-mesenchymal transition (EndMT). Using aortic ECs, we show here that active ...
  • Characterization of snail1 and pten transcriptional regulation by snail1: New insights into epithelial-to-mesenchymal transition and cell resistance to apoptosis
    Escrivà Izquierdo, María (Universitat Pompeu Fabra, 2011-04-12)
    The product of the snail1 gene (SNAIL1) is a transcriptional repressor required for triggering the epithelial-to-mesenchymal transition (EMT). SNAIL1 transcription is induced when epithelial cells are forced to acquire a ...
  • CK1ε and p120-catenin control Ror2 function in noncanonical wnt signaling
    Curto, Josué; Valle Pérez, Beatriz del; Villarroel, Aida; Fuertes, Guillem; Vinyoles, Meritxell; Peña, Raúl; García de Herreros, Antonio; Duñach, Mireia (Wiley, 2018)
    Canonical and noncanonical Wnt pathways share some common elements but differ in the responses they evoke. Similar to Wnt ligands acting through the canonical pathway, Wnts that activate the noncanonical signaling, such ...
  • Correction to Wnt controls the transcriptional activity of Kaiso through CK1ε-dependent phosphorylation of p120-catenin
    Valle Pérez, Beatriz del; Casagolda, David; Lugilde, Ero; Valls, Gabriela; Codina, Montserrat; Dave, Natàlia; García de Herreros, Antonio; Duñach, Mireia (Company of Biologists, 2016)
    There was an error published in J. Cell Sci. 124, 2298–2309.
  • Data from proteomic characterization of the role of Snail1 in murine mesenchymal stem cells and 3T3-L1 fibroblasts differentiation.
    Peláez García, Alberto; Barderas, Rodrigo; Mendes, Marta; López Lucendo, María; Sanchez, J.C.; García de Herreros, Antonio; Casal, José Ignacio (Elsevier, 2015)
    The transcription factor (TF) Snail1 is a major inducer of the epithelial-mesenchymal transition (EMT) during embryonic development and cancer progression. Ectopic expression of Snail in murine mesenchymal stem cells (mMSC) ...
  • Deubiquitinating enzymes stabilizing Snail1 transcription factor : a role for USP27X in epithelial-to-mesenchymal transition
    Lambies Barjau, Guillem, 1990- (Universitat Pompeu Fabra, 2019-02-14)
    Cancer cells undergo epithelial-to-mesenchymal transition (EMT) to dissociate from the primary tumor and to survive to chemotherapy. EMT is controlled by Snail1, a transcriptional factor also required for the activation ...
  • Dual role of Snail1 as transcriptional repressor and activator
    García de Herreros, Antonio (Elsevier, 2024)
    Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition, a process that remodels tumor cells increasing their invasion and chemo-resistance as well as reprograms their metabolism ...
  • Efecte represor de Snail en la proliferació cel·lular
    Virgós Soler, Ariadna (Universitat Pompeu Fabra, 2011-04-12)
    La Transició Epiteli-Mesènquima és el mecanisme pel qual les cèl·lules epitelials generades en regions particulars, poden dissociar-se de l'epiteli i migrar cap a nous destins, gràcies a uns canvis morfològics que transformen ...
  • Endothelial cell activation on 3D-matrices derived from PDGF-BB-stimulated fibroblasts is mediated by Snail1
    Herrera, Alberto; Herrera, Mercedes; Guerra-Perez, Natalia; Galindo-Pumariño, Cristina; Larriba, María Jesús; García-Barberán, Vanesa; Gil, Beatriz; Giménez-Moyano, Sara; Ferreiro-Monteagudo, Reyes; Veguillas, Pilar; Candia, Antonio; Peña, Raúl; Pinto, Jesús; García-Bermejo, Mª Laura; Muñoz, Alberto; García de Herreros, Antonio; Bonilla, Félix; Carrato, Alfredo; Peña, Cristina (Nature Research, 2018)
    Carcinomas, such as colon cancer, initiate their invasion by rescuing the innate plasticity of both epithelial cells and stromal cells. Although Snail is a transcriptional factor involved in the Epithelial-Mesenchymal ...
  • Endothelial Snail1 in angiogenesis and tumorigenesis
    Cabrerizo Granados, David (Universitat Pompeu Fabra, 2021-01-07)
    Snail1 is a transcriptional factor with a great relevance in tumor development as it is required for epithelial to mesenchymal transition and activation of cancer-associated fibroblasts (CAF). In this thesis, we reported ...

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