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Browsing by Author "García de Herreros, Antonio"
Now showing items 1-20 of 70
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Casagolda, David; Valle Pérez, Beatriz del; Valls, Gabriela; Lugilde, Ero; Vinyoles, Meritxell; Casado Vela, Juan; Solanas, Guiomar; Batlle Gómez, Eduard; Reynolds, Albert B.; Casal, José Ignacio; García de Herreros, Antonio; Duñach, Mireia (Company of Biologists, 2010)p120-catenin is an E-cadherin-associated protein that modulates E-cadherin function and stability. We describe here that p120-catenin is required for Wnt pathway signaling. p120-catenin binds and is phosphorylated by CK1ε ...
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Peláez García, Alberto; Barderas, Rodrigo; Batlle Gómez, Raquel; Viñas Castells, Rosa, 1985-; Bartolome, Rubén A.; Torres, Sofía; Mendes, Marta; López Lucendo, María; Mazzolini, Rocco; Bonilla, Félix; García de Herreros, Antonio; Casal, José Ignacio (American Society for Biochemistry and Molecular Biology (ASBMB), 2015)Adipogenesis requires a differentiation program driven by multiple transcription factors, where PPARγ and C/EBPα play a central role. Recent findings indicate that Snail inhibits adipocyte differentiation in 3T3-L1 and ...
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Vincent, Theresa; Neve, Etienne P.A.; Johnson, Jill R.; Kukalev, Alexander; Rojo, Federico; Albanell Mestres, Joan; Pietras, Kristian; Virtanen, Ismo; Philipson, Lennart; Leopold, Philip L.; Crystal, Ronald G.; García de Herreros, Antonio; Moustakas, Aristidis; Petterson, Ralf F.; Fuxe, Jonas (Nature Research, 2009)Epithelial-mesenchymal transition (EMT) is essential for organogenesis and is triggered during carcinoma progression to an invasive state. Transforming growth factor-beta (TGF-beta) cooperates with signalling pathways, ...
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Vinyoles, Meritxell; Valle Pérez, Beatriz del; Curto, Josué; Padilla, Mary; Villarroel, Aida; Yang, J.Y.; García de Herreros, Antonio; Duñach, Mireia (Springer Nature, 2017)Canonical Wnt signaling induces the stabilization of β-catenin, its translocation to the nucleus and the activation of target promoters. This pathway is initiated by the binding of Wnt ligands to the Frizzled receptor, the ...
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Bruch Oms, Marina (Universitat Pompeu Fabra, 2022-12-15)Tumors are complex masses composed by multiple cell types, such as cancer associated fibroblasts (CAFs) and macrophages, that interact with each other promoting the tumor progression. Snail1 is a transcription factor ...
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Bruch Oms, Marina; Olivera-Salguero, Rubén, 1991-; Mazzolini, Rocco; Valle Pérez, Beatriz del; Mayo González, Paula; Beteta, Ángel; Peña Arranz, Raúl; García de Herreros, Antonio (Wiley, 2023)Snail1 is a transcriptional factor required for cancer-associated fibroblast (CAF) activation, and mainly detected in CAFs in human tumors. In the mouse mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT) model ...
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Bertoni, Martino; Duran-Frigola, Miquel, 1985-; Badia-I-Mompel, Pau; Pauls, Eduardo; Orozco Ruiz, Modesto; Guitart Pla, Oriol; Alcalde, Víctor; Diaz, Víctor M.; Berenguer-Llergo, Antonio; Brun-Heath, Isabelle; Villegas, Núria; García de Herreros, Antonio; Aloy, Patrick, 1972- (Nature Research, 2021)Chemical descriptors encode the physicochemical and structural properties of small molecules, and they are at the core of chemoinformatics. The broad release of bioactivity data has prompted enriched representations of ...
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Herrera, Mercedes; Herrera, Alberto; Domínguez, Gemma; Silva, Javier; García, Vanesa; García, Jose M.; Gómez, Irene; Soldevilla, Beatriz; Muñoz, Concepción; Provencio, Mariano; Campos Martin, Yolanda; García de Herreros, Antonio; Casal, José Ignacio; Bonilla, Félix; Peña, Cristina (Japanese Cancer Association, 2013)Tumor epithelial cells within a tumor coexist with a complex microenvironment in which a variety of interactions between its various components determine the behavior of the primary tumors. Cancer-associated fibroblasts ...
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Martínez-Martínez, Esther; Gómez, Irene; Martín, Paloma; Sánchez, Antonio J.; Román, Laura; Tejerina, Eva; Bonilla, Félix; García Merino, Antonio; García de Herreros, Antonio; Provencio, Mariano; García, Jose M. (Impact Journals, 2015)Many studies have demonstrated that the endocannabinoid system (ECS) is altered in different tumor types, including colon cancer. However, little is known about the role of the ECS in tumor progression. Here we report the ...
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Frías Hernández, Àlex, 1985- (Universitat Pompeu Fabra, 2015-12-10)Notch activation in aortic endothelial cells (ECs) takes place at embryonic stages during cardiac valve formation and induces an endothelial-to-mesenchymal transition (EndMT). Using aortic ECs, we show here that active ...
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Escrivà Izquierdo, María (Universitat Pompeu Fabra, 2008-06-20)The product of the snail1 gene (SNAIL1) is a transcriptional repressor required for triggering the epithelial-to-mesenchymal transition (EMT). SNAIL1 transcription is induced when epithelial cells are forced to acquire a ...
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Curto, Josué; Valle Pérez, Beatriz del; Villarroel, Aida; Fuertes, Guillem; Vinyoles, Meritxell; Peña, Raúl; García de Herreros, Antonio; Duñach, Mireia (Wiley, 2018)Canonical and noncanonical Wnt pathways share some common elements but differ in the responses they evoke. Similar to Wnt ligands acting through the canonical pathway, Wnts that activate the noncanonical signaling, such ...
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Valle Pérez, Beatriz del; Casagolda, David; Lugilde, Ero; Valls, Gabriela; Codina, Montserrat; Dave, Natàlia; García de Herreros, Antonio; Duñach, Mireia (Company of Biologists, 2016)There was an error published in J. Cell Sci. 124, 2298–2309.
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Peláez García, Alberto; Barderas, Rodrigo; Mendes, Marta; López Lucendo, María; Sanchez, J.C.; García de Herreros, Antonio; Casal, José Ignacio (Elsevier, 2015)The transcription factor (TF) Snail1 is a major inducer of the epithelial-mesenchymal transition (EMT) during embryonic development and cancer progression. Ectopic expression of Snail in murine mesenchymal stem cells (mMSC) ...
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Lambies Barjau, Guillem, 1990- (Universitat Pompeu Fabra, 2019-01-10)Cancer cells undergo epithelial-to-mesenchymal transition (EMT) to dissociate from the primary tumor and to survive to chemotherapy. EMT is controlled by Snail1, a transcriptional factor also required for the activation ...
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Virgós Soler, Ariadna (Universitat Pompeu Fabra, 2008-07-23)La Transició Epiteli-Mesènquima és el mecanisme pel qual les cèl·lules epitelials generades en regions particulars, poden dissociar-se de l'epiteli i migrar cap a nous destins, gràcies a uns canvis morfològics que transformen ...
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Herrera, Alberto; Herrera, Mercedes; Guerra-Perez, Natalia; Galindo-Pumariño, Cristina; Larriba, María Jesús; García-Barberán, Vanesa; Gil, Beatriz; Giménez-Moyano, Sara; Ferreiro-Monteagudo, Reyes; Veguillas, Pilar; Candia, Antonio; Peña, Raúl; Pinto, Jesús; García-Bermejo, Mª Laura; Muñoz, Alberto; García de Herreros, Antonio; Bonilla, Félix; Carrato, Alfredo; Peña, Cristina (Nature Research, 2018)Carcinomas, such as colon cancer, initiate their invasion by rescuing the innate plasticity of both epithelial cells and stromal cells. Although Snail is a transcriptional factor involved in the Epithelial-Mesenchymal ...
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Cabrerizo Granados, David, 1993- (Universitat Pompeu Fabra, 2021-01-07)Snail1 is a transcriptional factor with a great relevance in tumor development as it is required for epithelial to mesenchymal transition and activation of cancer-associated fibroblasts (CAF). In this thesis, we reported ...
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Celià-Terrassa, Toni; García de Herreros, Antonio; Thomson, Timothy M. (American Society for Clinical Investigation, 2012)Malignant progression in cancer requires populations of tumor-initiating cells (TICs) endowed with unlimited self renewal, survival under stress, and establishment of distant metastases. Additionally, the acquisition of ...
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Moustakas, Aristidis; García de Herreros, Antonio (Wiley, 2017)
Now showing items 1-20 of 70
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