Browsing by Author "Gallardo Hernández, Fernando"

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  • Chromatin-bound IκB-alpha regulates a subset of polycomb target genes in differentiation and cancer
    Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika, 1986-; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2013)
    IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of ...
  • Cost of early-stage mycosis fungoides treatments in Spain
    Ortiz-Romero, Pablo L.; Servitje, Octavio; Estrach, Teresa; Izu-Belloso, Rosa María; Fernández-de-Misa, Ricardo; Gallardo Hernández, Fernando; López-Martínez, Noemí; Pérez-Mitru, Alejandro (Dove Medical Press, 2020)
    Aim: To identify the most common therapeutic options for the treatment of early-stage mycosis fungoides in Spain, quantify their associated healthcare resource use and costs. Methods: After reviewing the literature, a panel ...
  • Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance.
    Gallardo Hernández, Fernando; Padrón, Andreina; Garcia Carbonell, Ricard; Rius, Cristina; González-Pérez, Abel; Arumí, Montserrat; Iglesias Coma, Mar; Nonell Mazelón, Lara; Bellosillo Paricio, Beatriz; Segura Tigell, Sonia; Pujol Vallverdú, Ramon Maria; López Bigas, Núria; Bertran, Joan; Bigas Salvans, Anna; Espinosa Blay, Lluís (Impact Journal, 2015)
    Invasive malignant melanoma (MM) is an aggressive tumor with no curative therapy available in advanced stages. Nuclear corepressor (NCoR) is an essential regulator of gene transcription, and its function has been found ...
  • Dabrafenib in an elderly patient with metastatic melanoma and BRAF V600R mutation: a case report.
    Casadevall Aguilar, David; Vidal Barrull, Joana; Gallardo Hernández, Fernando; Zuccarino, Flavio; Arumí, Montserrat; Dalmases Massegú, Alba, 1982-; Bellosillo Paricio, Beatriz; Montagut Viladot, Clara (BioMed Central, 2016)
    BACKGROUND: Approximately 50 % of malignant melanomas harbor activating point mutations in the BRAF gene. Typically, these mutations result in the substitution of the amino acid valine at codon 600 of the gene, and 90-95 ...
  • Diagnostic value of genotypic analysis in primary cutaneous lymphomas using standardized BIOMED-2 polymerase chain reaction protocols: experience in daily clinical practice
    López-Aventín, Daniel; Gallardo Hernández, Fernando; Colomo Saperas, Luis Alberto; Moragón, Ester; Vela Ortíz, María del Carmen; Duran Jordà, Xavier, 1974-; Bellosillo Paricio, Beatriz; Pujol Vallverdú, Ramon Maria (Society for Publication of Acta Dermato-Venereologica, 2021)
    BIOMED-2 Concerted Action BMH4-CT98-3936 (BIOMED-2) PCR protocols are an important diagnostic tool in the evaluation of cutaneous lymphomas. The aim of this study was to assess the diagnostic value of the genotyping results ...
  • Effectiveness and safety of ustekinumab 90 Mg in Patients weighing 100 Kg or less: a retrospective, observational, multicenter study
    Del Alcázar, Elena; Ferran Farrés, Marta; López-Ferrer, Anna; Notario, Jaime; Vidal, David; Riera, José; Aparicio, Gloria; Gallardo Hernández, Fernando; Vilarrasa, Eva; Alsina, Mercè; Puig, Lluís; Ferrándiz, Carlos; Carrascosa, José M. (Informa Healthcare, 2020)
    Background: Scant information from clinical practice is available on the effectiveness and safety of ustekinumab (UST) 90 mg in patients with psoriasis weighing 100 kg or less.Objectives: To assess the effectiveness and ...
  • Epigenetic silencing of tumor suppressor miR-124 directly supports STAT3 activation in cutaneous T-Cell lymphoma
    García-Colmenero, Lidia; González Miranda, Jessica; Sandoval, Juan; Guillén, Yolanda; Diaz-Lagares, Angel; Andrades, Evelyn; Iglesias, Arnau; Nonell Mazelón, Lara; Pujol Vallverdú, Ramon Maria; Bigas Salvans, Anna; Espinosa Blay, Lluís; Gallardo Hernández, Fernando (MDPI, 2020)
    Increasing evidence supports a potential role for STAT3 as a tumor driver in cutaneous T-cell lymphomas (CTCL). The mechanisms leading to STAT3 activation are not fully understood; however, we recently found that miR-124, ...
  • Genetics abnormalities with clinical impact in primary cutaneous lymphomas
    Gallardo Hernández, Fernando; Pujol Vallverdú, Ramon Maria (MDPI, 2022)
    Primary cutaneous lymphomas comprise a heterogeneous group of extranodal non-Hodgkin lymphomas (NHL) that arise from skin resident lymphoid cells and are manifested by specific lymphomatous cutaneous lesions with no evidence ...
  • Identification of gene mutations and fusion genes in patients with Sézary syndrome.
    Prasad, Aparna; Rabionet, Raquel; Espinet Solà, Blanca; Zapata Ortiz, Luis, 1985-; Puiggros Metje, Anna Maria; Melero Vilella, Maria Carme; Puig, Anna; Sarria-Trujillo, Yaris; Ossowski, Stephan; Garcia-Muret, Maria P.; Estrach, Teresa; Servitje, Octavio; Lopez-Lerma, Ingrid; Gallardo Hernández, Fernando; Pujol Vallverdú, Ramon Maria; Estivill, Xavier, 1955- (Elsevier, 2016)
    Sézary syndrome is a leukemic form of cutaneous T-cell lymphoma with an aggressive clinical course. The genetic etiology of the disease is poorly understood, with chromosomal abnormalities and mutations in some genes being ...
  • Imatinib treatment of lymphomatoid papulosis associated with myeloproliferative hypereosinophilic syndrome presenting the FIP1L1-PDGFRA fusion gene.
    García-Martínez, Pablo; Sitjas, Dolors; Llistosella, Enric; Espinet Solà, Blanca; Rodríoguez Rivera, María; Gallardo Hernández, Fernando; Pujol Vallverdú, Ramon Maria (Society for Publication of Acta Dermato-Venereologica, 2017)
    Peripheral blood eosinophilia has been reported to occur in a wide range of haematological malignancies including primary cutaneous lymphomas. The concurrence of lymphomatoid papulosis (LyP) with peripheral blood eosinophilia ...
  • Linfomas cutáneos. Parte I: micosis fungoide, síndrome de Sézary y proliferaciones linfoides cutáneas CD30 positivas
    Pujol Vallverdú, Ramon Maria; Gallardo Hernández, Fernando (Elsevier, 2021)
    Los linfomas cutáneos primarios son un grupo heterogéneo de procesos linfoproliferativos malignos que se manifiestan inicialmente en la piel sin evidencia de afectación extracutánea en el momento del diagnóstico y que ...
  • Linfomas cutáneos. Parte II: otros linfomas cutáneos
    Pujol Vallverdú, Ramon Maria; Gallardo Hernández, Fernando (Elsevier, 2021)
    Los linfomas cutáneos primarios de células T distintos de la micosis fungoide, el síndrome de Sézary y los procesos linfoproliferativos cutáneos positivos para CD30 son poco frecuentes, representan menos del 5% de todos ...
  • Melanoma incidence increases in the elderly of Catalonia but not in the younger population: effect of prevention or consequence of immigration?
    Puig, Susana; Gallardo Hernández, Fernando; Malvehy, Josep (Society for Publication of Acta Dermato-Venereologica, 2015)
    All cases of MM diagnosed in 23 hospitals in Catalonia, from 2000 to 2007 were recorded and melanoma incidence calculated and adjusted for the European standard population via the direct method. The age standardised ...
  • Novel phosphorylated TAK1 species with functional impact on NF-κB and β-catenin signaling in human Cutaneous T-cell lymphoma
    Gallardo Hernández, Fernando; Bertran, Joan; López Arribillaga, Erika, 1986-; González, Jessica; Menéndez, Silvia; Sánchez Güerri, Ignacio; Colomo Saperas, Luis Alberto; Iglesias Coma, Mar; Garrido, Marta; Santamaría-Babí, Luis Francisco; Torres, Ferran; Pujol Vallverdú, Ramon Maria; Bigas Salvans, Anna; Espinosa Blay, Lluís (Nature Publishing Group, 2018)
  • Patients with moderate to severe psoriasis associate with higher risk of depression and anxiety symptoms: results of a multivariate study of 300 spanish individuals with psoriasis
    Tribó Boixareu, María José; Turroja, Marta; Castaño Vinyals, Gemma; Bulbena Vilarrasa, Antonio; Ros, Elena; García-Martínez, Pablo; Tausk, Francisco; Sagristà, Marc; Pujol Vallverdú, Ramon Maria; Ferran Farrés, Marta; Gallardo Hernández, Fernando (Society for Publication of Acta Dermato-Venereologica, 2019)
    Psoriasis is a chronic skin disease associated with considerable physical and psychological comorbidities. Stress and emotional disturbances have been implicated in both triggering the onset and exacerbation of psoriasis. ...
  • Psoriasiform eruption secondary to PI3K-delta inhibitor: expanding the spectrum of psoriasiform paradoxical reactions?
    Pesqué, David; Sánchez González, Blanca; Gallardo Hernández, Fernando; Segura Tigell, Sonia; Pujol Vallverdú, Ramon Maria (Society for Publication of Acta Dermato-Venereologica, 2021)
  • Recent advances in T-cell lymphoid neoplasms
    Bigas Salvans, Anna; Rodríguez-Sevilla, Juan José; Espinosa Blay, Lluís; Gallardo Hernández, Fernando (Elsevier, 2022)
    T Cells comprise many subtypes of specified lymphocytes, and their differentiation and function take place in different tissues. This cellular diversity is also observed in the multiple ways T-cell transformation gives ...
  • Sézary syndrome patient-derived models allow drug selection for personalized therapy
    Gallardo Hernández, Fernando; Andrades, Evelyn; Iglesias, Arnau; González, Jessica; Solé, Laura; Guillén, Yolanda; Blanco Ares, Gonzalo, 1989-; Colomo Saperas, Luis Alberto; Gimeno, Eva; Conde Estévez, David; Rodríguez, Eva; Bielsa-Marsol, Isabel; Iglesias Coma, Mar; Bellosillo Paricio, Beatriz; Pujol Vallverdú, Ramon Maria; Regueiro, José R.; Bigas Salvans, Anna; Espinosa Blay, Lluís (American Society of Hematology, 2022)
    Current therapeutic approaches for Sézary syndrome (SS) do not achieve a significant improvement in long-term survival of patients, and they are mainly focused on reducing blood tumor burden to improve quality of life. ...
  • Telangiectatic Mycosis Fungoides: A New Clinicopathological Presentation Mimicking Acquired Naevoid Telangiectasia
    García Colmenero, Lidia; Curto Barredo, Laia; Gómez Martín, Ignacio; Gallardo Hernández, Fernando; Pujol Vallverdú, Ramon Maria (Society for Publication of Acta Dermato-Venereologica, 2017)
  • Ultrasound assessment of psoriatic onychopathy: a cross-sectional study comparing psoriatic onychopathy with onychomycosis
    Moreno, Mireia; Lisbona Pérez, María Pilar; Gallardo Hernández, Fernando; Deza Vargas, Luis Gustavo; Ferran Farrés, Marta; Pontes, Caridad; Luelmo, Jesús; Maymó Guarch, Joan; Gratacós, Jordi (Society for Publication of Acta Dermato-Venereologica, 2019)
    This cross-sectional study evaluated the usefulness of an ultrasound technique in assessment of nail changes in 35 patients with psoriatic onychopathy and 25 with nail dystrophy secondary to onychomycosis. All patients ...