Browsing by Author "Güell Cargol, Marc, 1982-"

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  • Sanvicente García, Marta; García Valiente, Albert; Jouide, Socayna; Jaraba-Wallace, Jessica; Bautista, Eric; Escobosa Olmo, Marc; Sánchez-Mejías, Avencia; Güell Cargol, Marc, 1982- (Public Library of Science (PLoS), 2023)
    Gene editing characterization with currently available tools does not always give precise relative proportions among the different types of gene edits present in an edited bulk of cells. We have developed CRISPR-Analytics, ...
  • Knödlseder, Nastassia; Fábrega, María José; Santos Moreno, Javier; Manils, Joan; Toloza, Lorena; Marín Vilar, Maria; Fernández Avilés, Cristina; Broadbent, Katrina; Maruotti, Julien; Lemenager, Hélène; Carolis, Carlo; Zouboulis, Christos C.; Soler Prat, Concepció; Lood, Rolf; Brüggemann, Holger; Güell Cargol, Marc, 1982- (Nature Research, 2024)
    Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to ...
  • Puig, Jaume; Knödlseder, Nastassia; Quera Jordana, Jaume; Algara López, Manuel-Ignacio; Güell Cargol, Marc, 1982- (Frontiers, 2021)
    Some organisms have shown the ability to naturally survive in extreme environments, even outer space. Some of these have natural mechanisms to resist severe DNA damage from conditions such as ionizing and non-ionizing ...
  • Smith, Cory J.; Castanon, Oscar; Said, Khaled; Volf, Verena; Khoshakhlagh, Parastoo; Hornick, Amanda; Ferreira, Raphael; Wu, Chun-Ting; Güell Cargol, Marc, 1982-; Garg, Shilpa; Ng, Alex H. M.; Myllykallio, Hannu; Church, George M. (Oxford University Press, 2020)
    To extend the frontier of genome editing and enable editing of repetitive elements of mammalian genomes, we made use of a set of dead-Cas9 base editor (dBE) variants that allow editing at tens of thousands of loci per cell ...
  • Knödlseder, Nastassia; Nevot, Guillermo; Fábrega, María José; Mir-Pedrol, Júlia; Sanvicente-García, Marta; Campamà-Sanz, Nil; Paetzold, Bernhard, 1981-; Lood, Rolf; Güell Cargol, Marc, 1982- (Public Library of Science (PLoS), 2022)
    Cutibacterium acnes (C. acnes) is a gram-positive bacterium and a member of the human skin microbiome. Despite being the most abundant skin commensal, certain members have been associated with common inflammatory disorders ...
  • Fábrega, María José; Knödlseder, Nastassia; Nevot, Guillermo; Sanvicente, Marta; Toloza, Lorena; Santos Moreno, Javier; Güell Cargol, Marc, 1982- (American Chemical Society (ACS), 2021)
    In the past few years, new bacterial-cell-free transcription-translation systems have emerged as potent and quick platforms for protein production as well as for prototyping of DNA regulatory elements, genetic circuits, ...
  • Alonso-Lerma, Borja; Güell Cargol, Marc, 1982-; Perez-Jimenez, Raul (Nature Research, 2023)
    Clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9 is an effector protein that targets invading DNA and plays a major role in the prokaryotic adaptive immune system. Although Streptococcus ...
  • Pallarès-Masmitjà, Maria; Ivančić, Dimitrije; Mir-Pedrol, Júlia; Jaraba-Wallace, Jessica; Tagliani, Tommaso; Oliva Miguel, Baldomero; Rahmeh, Amal; Sánchez-Mejías, Avencia; Güell Cargol, Marc, 1982- (Nature Research, 2021)
    While multiple technologies for small allele genome editing exist, robust technologies for targeted integration of large DNA fragments in mammalian genomes are still missing. Here we develop a gene delivery tool (FiCAT) ...
  • Rozas, Miquel; Hart de Ruijter, Astrid; Fábrega, María José; Zorgani, Amine; Güell Cargol, Marc, 1982-; Paetzold, Bernhard, 1981-; Brillet, François (MDPI, 2021)
    Cutibacterium acnes is the most abundant bacterium living in human, healthy and sebum-rich skin sites, such as the face and the back. This bacterium is adapted to this specific environment and therefore could have a major ...
  • Güell Cargol, Marc, 1982- (Universitat de Barcelona, 2019)
    DNA read and write technologies have accelerated biotechnology at an unprecedented pace. This enhanced capacity to engineer living beings has accelerated not only scientific research, but also the translation into novel ...
  • Fang, Lei; Güell Cargol, Marc, 1982-; Church, George M.; Pfeifer, Blaine A. (Wiley, 2018)
    The establishment of erythromycin production within the heterologous host E. coli marked an accomplishment in genetic transfer capacity. Namely, over 20 genes and 50 kb of DNA was introduced to E. coli for successful ...
  • Niu, Dong; Wei, Hong-Jiang; Lin, Lin; George, Haydy; Wang, Tao; Lee, I-Hsiu; Zhao, Hong-Ye; Wang, Yong; Kan, Yinan; Shrock, Ellen; Lesha, Emal; Wang, Gang; Luo, Yonglun; Qing, Yubo; Jiao, Deling; Zhao, Heng; Zhou, Xiaoyang; Wang, Shouqi; Wei, Hong-Jiang; Güell Cargol, Marc, 1982-; Church, George M.; Yang, Luhan (American Association for the Advancement of Science (AAAS), 2017)
    Xenotransplantation is a promising strategy to alleviate the shortage of organs for human transplantation. In addition to the concerns about pig-to-human immunological compatibility, the risk of cross-species transmission ...
  • Ivančić, Dimitrije; Mir-Pedrol, Júlia; Jaraba-Wallace, Jessica; Rafel i Fontanals, Núria, 1954-; Sánchez-Mejías, Avencia; Güell Cargol, Marc, 1982- (BioMed Central, 2022)
    Comprehensive characterisation of genome engineering technologies is relevant for their development and safe use in human gene therapy. Short-read based methods can overlook insertion events in repetitive regions. We develop ...
  • Martí Baena, Quim; Pascuet Fontanet, Andreu; Berjaga Buisan, Tomas; Caravaca Rodríguez, Miriam; Puig Costa-Jussà, Jaume; Sánchez Mejías, Avencia; Ivančić, Dimitrije; Mogas Díez, Sira; Güell Cargol, Marc, 1982-; Macía, Javier (Frontiers, 2024)
    Although blood sampling and medical imaging are well-established techniques in clinical diagnostics, they often require long post-processing procedures. Fast and simple quantification of signaling molecules can enable ...
  • Pol Cros, Maria; Mir-Pedrol, Júlia; Toloza, Lorena; Knödlseder, Nastassia; Maruotti, Julien; Zouboulis, Christos C.; Güell Cargol, Marc, 1982-; Fábrega, María José (Nature Research, 2023)
    Cutibacterium acnes (C. acnes) is one of the most prevalent bacteria that forms the human skin microbiota. Specific phylotypes of C. acnes have been associated with the development of acne vulgaris, while other phylotypes ...
  • Cavazza, Alessia; Güell Cargol, Marc, 1982-; COST Action CA21113 (Elsevier, 2023)
    The European Cooperation in Science and Technology (COST) is an intergovernmental organization dedicated to funding and coordinating scientific and technological research in Europe, fostering collaboration among researchers ...
  • Mali, Prashant; Yang, Luhan; Esvelt, Kevin M.; Aach, John; Güell Cargol, Marc, 1982-; DiCarlo, James E.; Norville, Julie E.; Church, George M. (American Association for the Advancement of Science (AAAS), 2013)
    Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that use short RNA to direct degradation of foreign ...
  • Koraglan, Ante; Paetzold, Bernhard, 1981-; Pereira de Lima, Joao; Brüggemann, Holger; Tüting, Thomas; Schanze, Denny; Güell Cargol, Marc, 1982-; Gollnick, Harald (Society for Publication of Acta Dermato-Venereologica, 2019)
    Imbalance in skin microflora, particularly related to certain Cutibacterium acnes strains, may trigger acne. Application of non-acne-causing strains to the skin may modulate the skin microbiome and thereby lead to a reduction ...
  • Paetzold, Bernhard, 1981-; Willis, Jesse R.; Pereira de Lima, Joao; Knödlseder, Nastassia; Brüggemann, Holger; Quist, Sven Roy; Gabaldón Estevan, Juan Antonio, 1973-; Güell Cargol, Marc, 1982- (BioMed Central, 2019)
    Background: The skin is colonized by a large number of microorganisms, most of which are beneficial or harmless. However, disease states of skin have specific microbiome compositions that are different from those of healthy ...

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