Browsing by Author "Güell Cargol, Marc, 1982-"

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  • Sanvicente García, Marta (Universitat Pompeu Fabra, 2023-05-25)
    Precision and accuracy are paramount for the use of genome editing in clinic, environmental, and industrial applications. These fields require reliable and traceable results to ensure the safety and viability of the resulting ...
  • Güell Cargol, Marc, 1982- (Universitat Pompeu Fabra, 2011-04-12)
    With only 689 genes Mycoplasma pneumoniae (M. pneumoniae) is among the simplest known organisms. Because of this simplicity, mycoplasma represents an attractive organism for systems-wide analyses. Such approaches aiming ...
  • Sanvicente García, Marta; García Valiente, Albert; Jouide, Socayna; Jaraba-Wallace, Jessica; Bautista, Eric; Escobosa Olmo, Marc; Sánchez-Mejías, Avencia; Güell Cargol, Marc, 1982- (Public Library of Science (PLoS), 2023)
    Gene editing characterization with currently available tools does not always give precise relative proportions among the different types of gene edits present in an edited bulk of cells. We have developed CRISPR-Analytics, ...
  • Rozas Belmonte, Miquel (Universitat Pompeu Fabra, 2023-01-11)
    Certain skin disorders are associated with skin microbiome dysbiosis, highlighting the importance of the microbiome in the maintenance of the skin's healthy state. Modulating the microbiome to reestablish its healthy state ...
  • Puig, Jaume; Knödlseder, Nastassia; Quera Jordana, Jaume; Algara López, Manuel-Ignacio; Güell Cargol, Marc, 1982- (Frontiers, 2021)
    Some organisms have shown the ability to naturally survive in extreme environments, even outer space. Some of these have natural mechanisms to resist severe DNA damage from conditions such as ionizing and non-ionizing ...
  • Pallarès-Masmitjà, Maria (Universitat Pompeu Fabra, 2022-12-22)
    The need for efficient targeted integration of large DNA fragments in mammalian genomes is indisputable, although several nuclease-based technologies have been lately developed for small allele genome editing. In this ...
  • Smith, Cory J.; Castanon, Oscar; Said, Khaled; Volf, Verena; Khoshakhlagh, Parastoo; Hornick, Amanda; Ferreira, Raphael; Wu, Chun-Ting; Güell Cargol, Marc, 1982-; Garg, Shilpa; Ng, Alex H. M.; Myllykallio, Hannu; Church, George M. (Oxford University Press, 2020)
    To extend the frontier of genome editing and enable editing of repetitive elements of mammalian genomes, we made use of a set of dead-Cas9 base editor (dBE) variants that allow editing at tens of thousands of loci per cell ...
  • Knödlseder, Nastassia; Nevot, Guillermo; Fábrega, María José; Mir-Pedrol, Júlia; Sanvicente-García, Marta; Campamà-Sanz, Nil; Paetzold, Bernhard, 1981-; Lood, Rolf; Güell Cargol, Marc, 1982- (Public Library of Science (PLoS), 2022)
    Cutibacterium acnes (C. acnes) is a gram-positive bacterium and a member of the human skin microbiome. Despite being the most abundant skin commensal, certain members have been associated with common inflammatory disorders ...
  • Fábrega, María José; Knödlseder, Nastassia; Nevot, Guillermo; Sanvicente, Marta; Toloza, Lorena; Santos-Moreno, Javier; Güell Cargol, Marc, 1982- (American Chemical Society (ACS), 2021)
    In the past few years, new bacterial-cell-free transcription-translation systems have emerged as potent and quick platforms for protein production as well as for prototyping of DNA regulatory elements, genetic circuits, ...
  • Alonso-Lerma, Borja; Güell Cargol, Marc, 1982-; Perez-Jimenez, Raul (Nature Research, 2023)
    Clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9 is an effector protein that targets invading DNA and plays a major role in the prokaryotic adaptive immune system. Although Streptococcus ...
  • Pallarès-Masmitjà, Maria; Ivančić, Dimitrije; Mir-Pedrol, Júlia; Jaraba-Wallace, Jessica; Tagliani, Tommaso; Oliva Miguel, Baldomero; Rahmeh, Amal; Sánchez-Mejías, Avencia; Güell Cargol, Marc, 1982- (Nature Research, 2021)
    While multiple technologies for small allele genome editing exist, robust technologies for targeted integration of large DNA fragments in mammalian genomes are still missing. Here we develop a gene delivery tool (FiCAT) ...
  • Rozas, Miquel; Hart de Ruijter, Astrid; Fábrega, María José; Zorgani, Amine; Güell Cargol, Marc, 1982-; Paetzold, Bernhard, 1981-; Brillet, François (MDPI, 2021)
    Cutibacterium acnes is the most abundant bacterium living in human, healthy and sebum-rich skin sites, such as the face and the back. This bacterium is adapted to this specific environment and therefore could have a major ...
  • Güell Cargol, Marc, 1982- (Universitat de Barcelona, 2019)
    DNA read and write technologies have accelerated biotechnology at an unprecedented pace. This enhanced capacity to engineer living beings has accelerated not only scientific research, but also the translation into novel ...
  • Fang, Lei; Güell Cargol, Marc, 1982-; Church, George M.; Pfeifer, Blaine A. (Wiley, 2018)
    The establishment of erythromycin production within the heterologous host E. coli marked an accomplishment in genetic transfer capacity. Namely, over 20 genes and 50 kb of DNA was introduced to E. coli for successful ...
  • Niu, Dong; Wei, Hong-Jiang; Lin, Lin; George, Haydy; Wang, Tao; Lee, I-Hsiu; Zhao, Hong-Ye; Wang, Yong; Kan, Yinan; Shrock, Ellen; Lesha, Emal; Wang, Gang; Luo, Yonglun; Qing, Yubo; Jiao, Deling; Zhao, Heng; Zhou, Xiaoyang; Wang, Shouqi; Wei, Hong-Jiang; Güell Cargol, Marc, 1982-; Church, George M.; Yang, Luhan (American Association for the Advancement of Science (AAAS), 2017)
    Xenotransplantation is a promising strategy to alleviate the shortage of organs for human transplantation. In addition to the concerns about pig-to-human immunological compatibility, the risk of cross-species transmission ...
  • Ivančić, Dimitrije; Mir-Pedrol, Júlia; Jaraba-Wallace, Jessica; Rafel i Fontanals, Núria, 1954-; Sánchez-Mejías, Avencia; Güell Cargol, Marc, 1982- (BioMed Central, 2022)
    Comprehensive characterisation of genome engineering technologies is relevant for their development and safe use in human gene therapy. Short-read based methods can overlook insertion events in repetitive regions. We develop ...
  • Pol Cros, Maria; Mir-Pedrol, Júlia; Toloza, Lorena; Knödlseder, Nastassia; Maruotti, Julien; Zouboulis, Christos C.; Güell Cargol, Marc, 1982-; Fábrega, María José (Nature Research, 2023)
    Cutibacterium acnes (C. acnes) is one of the most prevalent bacteria that forms the human skin microbiota. Specific phylotypes of C. acnes have been associated with the development of acne vulgaris, while other phylotypes ...
  • Cavazza, Alessia; Güell Cargol, Marc, 1982-; COST Action CA21113 (Elsevier, 2023)
    The European Cooperation in Science and Technology (COST) is an intergovernmental organization dedicated to funding and coordinating scientific and technological research in Europe, fostering collaboration among researchers ...
  • Mali, Prashant; Yang, Luhan; Esvelt, Kevin M.; Aach, John; Güell Cargol, Marc, 1982-; DiCarlo, James E.; Norville, Julie E.; Church, George M. (American Association for the Advancement of Science (AAAS), 2013)
    Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that use short RNA to direct degradation of foreign ...
  • Koraglan, Ante; Paetzold, Bernhard, 1981-; Pereira de Lima, Joao; Brüggemann, Holger; Tüting, Thomas; Schanze, Denny; Güell Cargol, Marc, 1982-; Gollnick, Harald (Society for Publication of Acta Dermato-Venereologica, 2019)
    Imbalance in skin microflora, particularly related to certain Cutibacterium acnes strains, may trigger acne. Application of non-acne-causing strains to the skin may modulate the skin microbiome and thereby lead to a reduction ...

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