Browsing by Author "Güell Cargol, Marc, 1982-"

Sort by: Order: Results:

  • CRISPR-Analytics (CRISPR-A): A platform for precise analytics and simulations for gene editing
    Sanvicente García, Marta; García Valiente, Albert; Jouide, Socayna; Jaraba-Wallace, Jessica; Bautista, Eric; Escobosa Olmo, Marc; Sánchez-Mejías, Avencia; Güell Cargol, Marc, 1982- (Public Library of Science (PLoS), 2023)
    Gene editing characterization with currently available tools does not always give precise relative proportions among the different types of gene edits present in an edited bulk of cells. We have developed CRISPR-Analytics, ...
  • Delivery of a sebum modulator by an engineered skin microbe in mice
    Knödlseder, Nastassia; Fábrega, María José; Santos Moreno, Javier; Manils, Joan; Toloza, Lorena; Marín Vilar, Maria; Fernández Avilés, Cristina; Broadbent, Katrina; Maruotti, Julien; Lemenager, Hélène; Carolis, Carlo; Zouboulis, Christos C.; Soler Prat, Concepció; Lood, Rolf; Brüggemann, Holger; Güell Cargol, Marc, 1982- (Nature Research, 2024)
    Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to ...
  • DNA damage protection for enhanced bacterial survival under simulated low earth orbit environmental conditions in Escherichia coli
    Puig, Jaume; Knödlseder, Nastassia; Quera Jordana, Jaume; Algara López, Manuel-Ignacio; Güell Cargol, Marc, 1982- (Frontiers, 2021)
    Some organisms have shown the ability to naturally survive in extreme environments, even outer space. Some of these have natural mechanisms to resist severe DNA damage from conditions such as ionizing and non-ionizing ...
  • Enabling large-scale genome editing at repetitive elements by reducing DNA nicking
    Smith, Cory J.; Castanon, Oscar; Said, Khaled; Volf, Verena; Khoshakhlagh, Parastoo; Hornick, Amanda; Ferreira, Raphael; Wu, Chun-Ting; Güell Cargol, Marc, 1982-; Garg, Shilpa; Ng, Alex H. M.; Myllykallio, Hannu; Church, George M. (Oxford University Press, 2020)
    To extend the frontier of genome editing and enable editing of repetitive elements of mammalian genomes, we made use of a set of dead-Cas9 base editor (dBE) variants that allow editing at tens of thousands of loci per cell ...
  • Engineering selectivity of Cutibacterium acnes phages by epigenetic imprinting
    Knödlseder, Nastassia; Nevot, Guillermo; Fábrega, María José; Mir-Pedrol, Júlia; Sanvicente-García, Marta; Campamà-Sanz, Nil; Paetzold, Bernhard, 1981-; Lood, Rolf; Güell Cargol, Marc, 1982- (Public Library of Science (PLoS), 2022)
    Cutibacterium acnes (C. acnes) is a gram-positive bacterium and a member of the human skin microbiome. Despite being the most abundant skin commensal, certain members have been associated with common inflammatory disorders ...
  • Establishing a cell-free transcription-translation platform for Cutibacterium acnes to prototype engineered metabolic and synthetic biology
    Fábrega, María José; Knödlseder, Nastassia; Nevot, Guillermo; Sanvicente, Marta; Toloza, Lorena; Santos Moreno, Javier; Güell Cargol, Marc, 1982- (American Chemical Society (ACS), 2021)
    In the past few years, new bacterial-cell-free transcription-translation systems have emerged as potent and quick platforms for protein production as well as for prototyping of DNA regulatory elements, genetic circuits, ...
  • Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins
    Alonso-Lerma, Borja; Güell Cargol, Marc, 1982-; Perez-Jimenez, Raul (Nature Research, 2023)
    Clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9 is an effector protein that targets invading DNA and plays a major role in the prokaryotic adaptive immune system. Although Streptococcus ...
  • Find and cut-and-transfer (FiCAT) mammalian genome engineering
    Pallarès-Masmitjà, Maria; Ivančić, Dimitrije; Mir-Pedrol, Júlia; Jaraba-Wallace, Jessica; Tagliani, Tommaso; Oliva Miguel, Baldomero; Rahmeh, Amal; Sánchez-Mejías, Avencia; Güell Cargol, Marc, 1982- (Nature Research, 2021)
    While multiple technologies for small allele genome editing exist, robust technologies for targeted integration of large DNA fragments in mammalian genomes are still missing. Here we develop a gene delivery tool (FiCAT) ...
  • From dysbiosis to healthy skin: major contributions of Cutibacterium acnes to skin homeostasis
    Rozas, Miquel; Hart de Ruijter, Astrid; Fábrega, María José; Zorgani, Amine; Güell Cargol, Marc, 1982-; Paetzold, Bernhard, 1981-; Brillet, François (MDPI, 2021)
    Cutibacterium acnes is the most abundant bacterium living in human, healthy and sebum-rich skin sites, such as the face and the back. This bacterium is adapted to this specific environment and therefore could have a major ...
  • Gene editing in translational research
    Güell Cargol, Marc, 1982- (Universitat de Barcelona, 2019)
    DNA read and write technologies have accelerated biotechnology at an unprecedented pace. This enhanced capacity to engineer living beings has accelerated not only scientific research, but also the translation into novel ...
  • Heterologous erythromycin production across strain and plasmid construction
    Fang, Lei; Güell Cargol, Marc, 1982-; Church, George M.; Pfeifer, Blaine A. (Wiley, 2018)
    The establishment of erythromycin production within the heterologous host E. coli marked an accomplishment in genetic transfer capacity. Namely, over 20 genes and 50 kb of DNA was introduced to E. coli for successful ...
  • Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9
    Niu, Dong; Wei, Hong-Jiang; Lin, Lin; George, Haydy; Wang, Tao; Lee, I-Hsiu; Zhao, Hong-Ye; Wang, Yong; Kan, Yinan; Shrock, Ellen; Lesha, Emal; Wang, Gang; Luo, Yonglun; Qing, Yubo; Jiao, Deling; Zhao, Heng; Zhou, Xiaoyang; Wang, Shouqi; Wei, Hong-Jiang; Güell Cargol, Marc, 1982-; Church, George M.; Yang, Luhan (American Association for the Advancement of Science (AAAS), 2017)
    Xenotransplantation is a promising strategy to alleviate the shortage of organs for human transplantation. In addition to the concerns about pig-to-human immunological compatibility, the risk of cross-species transmission ...
  • INSERT-seq enables high-resolution mapping of genomically integrated DNA using Nanopore sequencing
    Ivančić, Dimitrije; Mir-Pedrol, Júlia; Jaraba-Wallace, Jessica; Rafel i Fontanals, Núria, 1954-; Sánchez-Mejías, Avencia; Güell Cargol, Marc, 1982- (BioMed Central, 2022)
    Comprehensive characterisation of genome engineering technologies is relevant for their development and safe use in human gene therapy. Short-read based methods can overlook insertion events in repetitive regions. We develop ...
  • Intein-mediated thyroid hormone biosensors: towards controlled delivery of hormone therapy
    Martí Baena, Quim; Pascuet Fontanet, Andreu; Berjaga Buisan, Tomas; Caravaca Rodríguez, Miriam; Puig Costa-Jussà, Jaume; Sánchez Mejías, Avencia; Ivančić, Dimitrije; Mogas Díez, Sira; Güell Cargol, Marc, 1982-; Macía, Javier (Frontiers, 2024)
    Although blood sampling and medical imaging are well-established techniques in clinical diagnostics, they often require long post-processing procedures. Fast and simple quantification of signaling molecules can enable ...
  • New insights into the role of Cutibacterium acnes-derived extracellular vesicles in inflammatory skin disorders
    Pol Cros, Maria; Mir-Pedrol, Júlia; Toloza, Lorena; Knödlseder, Nastassia; Maruotti, Julien; Zouboulis, Christos C.; Güell Cargol, Marc, 1982-; Fábrega, María José (Nature Research, 2023)
    Cutibacterium acnes (C. acnes) is one of the most prevalent bacteria that forms the human skin microbiota. Specific phylotypes of C. acnes have been associated with the development of acne vulgaris, while other phylotypes ...
  • Progress and harmonization of gene editing to treat human diseases: Proceeding of COST Action CA21113 GenE-HumDi
    Cavazza, Alessia; Güell Cargol, Marc, 1982-; COST Action CA21113 (Elsevier, 2023)
    The European Cooperation in Science and Technology (COST) is an intergovernmental organization dedicated to funding and coordinating scientific and technological research in Europe, fostering collaboration among researchers ...
  • RNA-guided human genome engineering via Cas9
    Mali, Prashant; Yang, Luhan; Esvelt, Kevin M.; Aach, John; Güell Cargol, Marc, 1982-; DiCarlo, James E.; Norville, Julie E.; Church, George M. (American Association for the Advancement of Science (AAAS), 2013)
    Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that use short RNA to direct degradation of foreign ...
  • Safety and efficacy of topically applied selected cutibacterium acnes strains over five weeks in patients with acne vulgaris: an open-label, pilot study
    Koraglan, Ante; Paetzold, Bernhard, 1981-; Pereira de Lima, Joao; Brüggemann, Holger; Tüting, Thomas; Schanze, Denny; Güell Cargol, Marc, 1982-; Gollnick, Harald (Society for Publication of Acta Dermato-Venereologica, 2019)
    Imbalance in skin microflora, particularly related to certain Cutibacterium acnes strains, may trigger acne. Application of non-acne-causing strains to the skin may modulate the skin microbiome and thereby lead to a reduction ...
  • Sharper scissors: How TREX2 fine-tunes CRISPR-Cas9 nickases for precise editing
    Güell Cargol, Marc, 1982- (Elsevier, 2024)
  • Skin microbiome modulation induced by probiotic solutions
    Paetzold, Bernhard, 1981-; Willis, Jesse R.; Pereira de Lima, Joao; Knödlseder, Nastassia; Brüggemann, Holger; Quist, Sven Roy; Gabaldón Estevan, Juan Antonio, 1973-; Güell Cargol, Marc, 1982- (BioMed Central, 2019)
    Background: The skin is colonized by a large number of microorganisms, most of which are beneficial or harmless. However, disease states of skin have specific microbiome compositions that are different from those of healthy ...

Search DSpace

Browse

My Account

In collaboration with Compliant to Partaking