Browsing by Author "Friedländer, Marc R."

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  • Characterisation of novel microRNAs in the Black flying fox (Pteropus alecto) by deep sequencing
    Cowled, Christopher; Stewart, Cameron R; Likic, Vladimir A; Friedländer, Marc R.; Tachedjian, Mary; Jenkins, Kristie A; Tizard, Mark L; Cottee, Pauline; Marsh, Glenn A; Zhou, Peng; Baker, Michelle L; Bean, Andrew G; Wang, Lin-fa (BioMed Central, 2014)
    Background: Bats are a major source of new and emerging viral diseases. Despite the fact that bats carry and shed highly pathogenic viruses including Ebola, Nipah and SARS, they rarely display clinical symptoms of infection. ...
  • Dose and time effects of solar-simulated ultraviolet radiation on the in vivo human skin transcriptome
    Bustamante Pineda, Mariona; Hernandez-Ferrer, Carles, 1987-; Tewari, Angela; Sarria-Trujillo, Yaris; Harrison, Graham I.; Puigdecanet Riubugent, Eulàlia; Nonell Mazelón, Lara; Kang, W.; Friedländer, Marc R.; Estivill, Xavier, 1955-; González, Juan Ramón; Nieuwenhuijsen, Mark J.; Young, Antony R. (Wiley, 2019)
    BACKGROUND: Terrestrial ultraviolet (UV) radiation causes erythema, oxidative stress, DNA mutations and skin cancer. Skin can adapt to these adverse effects by DNA repair, apoptosis, keratinization and tanning. OBJECTIVES: ...
  • Environmental enrichment induces epigenomic and genome organization changes relevant for cognition
    Espeso Gil, Sergio, 1985-; Holik, Aliaksei Z.; Bonnin, Sarah; Jhanwar, Shalu, 1986-; Chandrasekaran, Sandhya; Pique Regi, Roger; Albaigès-Ràfols, Júlia; Maher, Michael; Permanyer, Jon; Irimia, Manuel; Friedländer, Marc R.; Pons Espinal, Meritxell, 1986-; Akbarian, Schahram; Dierssen, Mara; Maass, Philipp G.; Hor, Charlotte N.; Ossowski, Stephan (Frontiers, 2021)
    In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the ...
  • Evidence for the biogenesis of more than 1,000 novel human microRNAs
    Friedländer, Marc R.; Lizano González, Esther, 1974-; Houben, Anna JS; Bezdan, Daniela; Bañez Coronel, Mónica; Kudla, Grzegorz; Mateu Huertas, Elisabet, 1983-; Kagerbauer, Birgit; González Morilla, Justo; Chen, Kevin C; LeProust, Emily M; Martí Puig, Eulàlia; Estivill, Xavier, 1955- (BioMed Central, 2014)
    Background: MicroRNAs (miRNAs) are established regulators of development, cell identity and disease. Although nearly two thousand human miRNA genes are known and new ones are continuously discovered, no attempt has been ...
  • MapToCleave: High-throughput profiling of microRNA biogenesis in living cells
    Kang, Wenjing; Fromm, Bastian; Houben, Anna J.; Høye, Eirik; Bezdan, Daniela; Arnan Ros, Carme; Thrane, Kim; Asp, Michaela; Johnson, Rory; Biryukova, Inna; Friedländer, Marc R. (Elsevier, 2021)
    Previous large-scale studies have uncovered many features that determine the processing of microRNA (miRNA) precursors; however, they have been conducted in vitro. Here, we introduce MapToCleave, a method to simultaneously ...
  • Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells
    Tarbier, Marcel; Mackowiak, Sebastian D.; Frade, João; Catuara Solarz, Silvina, 1986-; Biryukova, Inna; Gelali, Eleni; Bárcena Menéndez, Diego, 1984-; Zapata Ortiz, Luis, 1985-; Ossowski, Stephan; Bienko, Magda; Gallant, Caroline J.; Friedländer, Marc R. (Nature Research, 2020)
    Single-cell RNA sequencing studies on gene co-expression patterns could yield important regulatory and functional insights, but have so far been limited by the confounding effects of differentiation and cell cycle. We apply ...
  • Sequence variation between 462 human individuals fine-tunes functional sites of RNA processing
    Ferreira, Pedro G.; Oti, Martin; Barann, Matthias; Wieland, Thomas; Ezquina, Suzana; Friedländer, Marc R.; Rivas, Manuel A.; Esteve-Codina, Anna; The GEUVADIS Consortium; Rosenstiel, Philip; Strom, Tim M.; Lappalainen, Tuuli; Guigó Serra, Roderic; Sammeth, Michael (Nature Publishing Group, 2016)
    Recent advances in the cost-efficiency of sequencing technologies enabled the combined DNA- and RNA-sequencing of human individuals at the population-scale, making genome-wide investigations of the inter-individual genetic ...
  • Signatures of positive selection reveal a universal role of chromatin modifiers as cancer driver genes
    Zapata Ortiz, Luis, 1985-; Sušak, Hana, 1985-; Drechsel, Oliver; Friedländer, Marc R.; Estivill, Xavier, 1955-; Ossowski, Stephan (Nature Publishing Group, 2017)
    Tumors are composed of an evolving population of cells subjected to tissue-specific selection, which fuels tumor heterogeneity and ultimately complicates cancer driver gene identification. Here, we integrate cancer cell ...
  • The acute effects of ultraviolet radiation on the blood transcriptome are independent
    Bustamante Pineda, Mariona; Hernandez-Ferrer, Carles, 1987-; Sarria-Trujillo, Yaris; Harrison, Graham I.; Nonell Mazelón, Lara; Kang, Wenjing; Friedländer, Marc R.; Estivill, Xavier, 1955-; González, Juan Ramón; Nieuwenhuijsen, Mark J.; Young, Antony R. (Elsevier, 2017)
    The molecular basis of many health outcomes attributed to solar ultraviolet radiation (UVR) is unknown. We tested the hypothesis that they may originate from transcriptional changes in blood cells. This was determined by ...
  • The circulating transcriptome as a source of biomarkers for melanoma
    Solé, Carla; Tramonti, Daniela; Schramm, Maike; Goicoechea, Ibai; Armesto, María; Hernandez, Luiza I.; Manterola, Lorea; Fernandez-Mercado, Marta; Mujika, Karmele; Tuneu, Anna; Jaka, Ane; Tellaetxe, Maitena; Friedländer, Marc R.; Estivill, Xavier, 1955-; Piazza, Paolo; Ortiz-Romero, Pablo L.; Middleton, Mark R.; Lawrie, Charles H. (MDPI, 2019)
    The circulating transcriptome is a valuable source of cancer biomarkers, which, with the exception of microRNAs (miRNAs), remains relatively unexplored. To elucidate which RNAs are present in plasma from melanoma patients ...