Browsing by Author "Foresti, Ombretta"

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  • Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion
    Lekszas, Caroline; Foresti, Ombretta; Raote, Ishier; Liedtke, Daniel; König, Eva Maria; Nanda, Indrajit; Vona, Barbara; Coster, Peter de; Cauwels, Rita; Malhotra, Vivek; Haaf, Thomas (eLife, 2020)
    The transport and Golgi organization 1 (TANGO1) proteins play pivotal roles in the secretory pathway. Full length TANGO1 is a transmembrane protein localised at endoplasmic reticulum (ER) exit sites, where it binds bulky ...
  • Defects in lipid homeostasis reflect the function of TANGO2 in phospholipid and neutral lipid metabolism
    Lujan, Agustin Leonardo; Foresti, Ombretta; Sugden, Conor; Brouwers, Nathalie; Farre, Alex Mateo; Vignoli, Alessio; Azamian, Mahshid; Turner, Alicia; Wojnacki, José; Malhotra, Vivek (eLife, 2023)
    We show that TANGO2 in mammalian cells localizes predominantly to mitochondria and partially at mitochondria sites juxtaposed to lipid droplets (LDs) and the endoplasmic reticulum. HepG2 cells and fibroblasts of patients ...
  • Golgi-dependent transport of vacuolar sorting receptors is regulated by COPII, AP1, and AP4 protein complexes in tobacco
    Gershlick, David Charles; de Marcos Lousa, Carine; Foresti, Ombretta; Lee, Andrew J.; Pereira, Estela A.; Pinto-daSilva, Luis L.; Bottanelli, Francesca; Denecke, Jurgen (Oxford University Press, 2014)
    The cycling of vacuolar sorting receptors (VSRs) between early and late secretory pathway compartments is regulated by signals in the cytosolic tail, but the exact pathway is controversial. Here, we show that receptor ...
  • Pla2g12b drives expansion of triglyceride-rich lipoproteins
    Thierer, James H.; Foresti, Ombretta; Yadav, Pradeep Kumar; Wilson, Meredith H.; Moll, Tabea O. C.; Shen, Meng-Chieh; Busch-Nentwich, Elisabeth M.; Morash, Margaret; Mohlke, Karen L.; Rawls, John F.; Malhotra, Vivek; Hussain, M. Mahmood; Farber, Steven A. (Nature Research, 2024)
    Vertebrates transport hydrophobic triglycerides through the circulatory system by packaging them within amphipathic particles called Triglyceride-Rich Lipoproteins. Yet, it remains largely unknown how triglycerides are ...
  • Quality control of protein complex assembly by a transmembrane recognition factor
    Natarajan, Nivedita; Foresti, Ombretta; Wendrich, Kim; Stein, Alexander; Carvalho, Pedro C. (Elsevier, 2020)
    The inner nuclear membrane (INM) is continuous with the endoplasmic reticulum (ER) but harbors a distinctive proteome essential for nuclear functions. In yeast, the Asi1/Asi2/Asi3 ubiquitin ligase complex safeguards the ...
  • Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4
    Foresti, Ombretta; Ruggiano, Annamaria, 1985-; Hannibal-Bach, Hans K.; Ejsing, Christer S.; Carvalho, Pedro C. (eLife, 2013)
    Sterol homeostasis is essential for the function of cellular membranes and requires feedback inhibition of HMGR, a rate-limiting enzyme of the mevalonate pathway. As HMGR acts at the beginning of the pathway, its regulation ...
  • TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes
    Raote, Ishier; Ortega Bellido, María; Santos, António J. M.; Foresti, Ombretta; Zhang, Chong; García Parajó, María F.; Campelo, Felix; Malhotra, Vivek (eLife, 2018)
    Collagen export from the endoplasmic reticulum (ER) requires TANGO1, COPII coats, and retrograde fusion of ERGIC membranes. How do these components come together to produce a transport carrier commensurate with the bulky ...
  • Tetraspanin-8 sequesters syntaxin-2 to control biphasic release propensity of mucin granules
    Wojnacki, José; Lujan, Agustin Leonardo; Brouwers, Nathalie; Aranda Vallejo, Carla; Bigliani, Gonzalo; Pena Rodriguez, Maria; Foresti, Ombretta; Malhotra, Vivek (Nature Research, 2023)
    Agonist-mediated stimulated pathway of mucin and insulin release are biphasic in which rapid fusion of pre-docked granules is followed by slow docking and fusion of granules from the reserve pool. Here, based on a cell-culture ...

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