Browsing by Author "Font Mateu, Jofre, 1977-"

Sort by: Order: Results:

  • A set of accessible enhancers enables the initial response of breast cancer cells to physiological progestin concentrations
    Zaurín Quer, Roser; Ferrari, Roberto; Nacht, A. Silvina; Carbonell-Caballero, Jose; Le Dily, François; Font Mateu, Jofre, 1977-; De Llobet, Lara Isabel; Vidal Ocabo, Enrique; Lioutas, Antonio, 1980-; Beato, Miguel; Vincent, Guillermo P. (Oxford University Press, 2021)
    Here, we report that in T47D breast cancer cells 50 pM progestin is sufficient to activate cell cycle entry and the progesterone gene expression program. At this concentration, equivalent to the progesterone blood levels ...
  • Atomic-resolution mapping of transcription factor-DNA interactions by femtosecond laser crosslinking and mass spectrometry
    Reim, Alexander; Ackermann, Roland; Font Mateu, Jofre, 1977-; Kammel, Robert; Beato, Miguel; Nolte, Stefan; Mann, Matthias; Russmann, Christoph; Wierer, Michael, 1982- (Nature Research, 2020)
    Transcription factors (TFs) regulate target genes by specific interactions with DNA sequences. Detecting and understanding these interactions at the molecular level is of fundamental importance in biological and clinical ...
  • CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells
    Wright, Roni H.G.; Castellano, Giancarlo; Bonet Martínez, Jaume, 1982-; Le Dily, François; Font Mateu, Jofre, 1977-; Ballaré, Cecilia Julia; Nacht, A. Silvina; Soronellas, Daniel; Oliva Miguel, Baldomero; Beato, Miguel (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)
    Eukaryotic gene regulation implies that transcription factors gain access to genomic information via poorly understood processes involving activation and targeting of kinases, histone-modifying enzymes, and chromatin ...
  • Chromatin remodeling in Drosophila preblastodermic embryo extract
    Šatović, Eva; Font Mateu, Jofre, 1977-; Carbonell, Albert; Beato, Miguel; Azorín Marín, Fernando (Nature Research, 2018)
    Chromatin is known to undergo extensive remodeling during nuclear reprogramming. However, the factors and mechanisms involved in this remodeling are still poorly understood and current experimental approaches to study it ...
  • Dynamics of progesterone receptor interactors in breast cancer cells upon hormone exposure
    Font Mateu, Jofre, 1977- (Universitat Pompeu Fabra, 2016-12-05)
    El receptor de la progesterona és un regulador clau per la proliferació de les cèl·lules de càncer de mama dependents d’hormona. El mecanisme d’acció del PR ha tingut un paper important en la resolució del mecanisme molecular ...
  • Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
    Page, Brent D.G.; Wright, Roni H.G.; Font Mateu, Jofre, 1977-; Beato, Miguel; Helleday, Thomas (Nature Research, 2018)
    With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-ribose and 8-oxo-guanine metabolism and was ...
  • The embryonic linker histone dBigH1 alters the functional state of active chromatin
    Climent-Cantó, Paula; Carbonell, Albert; Tatarski, Milos; Reina García, Óscar, 1976-; Bujosa, Paula; Font Mateu, Jofre, 1977-; Bernués, Jordi; Beato, Miguel; Azorín Marín, Fernando (Oxford University Press (OUP), 2020)
    Linker histones H1 are principal chromatin components, whose contribution to the epigenetic regulation of chromatin structure and function is not fully understood. In metazoa, specific linker histones are expressed in the ...