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Browsing by Author "Flores de los Heros, África, 1985-"

Browsing by Author "Flores de los Heros, África, 1985-"

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  • A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior
    Plaza-Zabala, Ainhoa, 1982-; Flores de los Heros, África, 1985-; Martín García, Elena, 1975-; Saravia Santos, Rocio, 1988-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Nature Publishing Group, 2013)
    Hypocretin/orexin signaling is critically involved in relapse to drug-seeking behaviors. In this study, we investigated the involvement of the hypocretin system in the reinstatement of nicotine-seeking behavior induced by ...
  • Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1
    Ten-Blanco, Marc; Flores de los Heros, África, 1985-; Pereda-Pérez, Inmaculada; Piscitelli, Fabiana; Izquierdo-Luengo, Cristina; Cristino, Luigia; Romero, Julián; Hillard, Cecilia J.; Maldonado, Rafael, 1961-; Di Marzo, Vicenzo; Berrendero Díaz, Fernando, 1971- (Elsevier, 2022)
    Anxiety and stress disorders are often characterized by an inability to extinguish learned fear responses. Orexins/hypocretins are involved in the modulation of aversive memories, and dysregulation of this system may ...
  • Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far
    Flores de los Heros, África, 1985-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Frontiers, 2013)
    Emerging findings suggest the existence of a cross-talk between hypocretinergic and endocannabinoid systems. Although few studies have examined this relationship, the apparent overlap observed in the neuroanatomical ...
  • CB1 cannabinoid receptors mediate cognitive deficits and structural plasticity changes during nicotine withdrawal
    Saravia Santos, Rocio, 1988-; Flores de los Heros, África, 1985-; Plaza-Zabala, Ainhoa, 1982-; Busquets Garcia, Arnau, 1985-; Pastor, Antonio; Torre Fornell, Rafael de la; Di Marzo, Vicenzo; Marsicano, Giovanni; Ozaita Mintegui, Andrés, 1969-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2017)
    BACKGROUND: Tobacco withdrawal is associated with deficits in cognitive function, including attention, working memory, and episodic memory. Understanding the neurobiological mechanisms involved in these effects is crucial ...
  • Facilitation of contextual fear extinction by orexin-1 receptor antagonism is associated with the activation of specific amygdala cell subpopulations
    Flores de los Heros, África, 1985-; Herry, Cyril; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Oxford University Press, 2017)
    BACKGROUND: Orexins are hypothalamic neuropeptides recently involved in the regulation of emotional memory. The basolateral amygdala, an area orchestrating fear memory processes, appears to be modulated by orexin transmission ...
  • Hypocretin/orexin signaling in the hypothalamic paraventricular nucleus is essential for the expression of nicotine withdrawal
    Plaza-Zabala, Ainhoa, 1982-; Flores de los Heros, África, 1985-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2012)
    BACKGROUND: Hypocretin (orexin) signaling is involved in drug addiction. In this study, we investigated the role of these hypothalamic neuropeptides in nicotine withdrawal by using behavioral and neuroanatomical approaches. ...
  • Influence of δ-opioid receptors in the behavioral effects of nicotine
    Berrendero Díaz, Fernando, 1971-; Plaza-Zabala, Ainhoa, 1982-; Galeote González, Lola; Flores de los Heros, África, 1985-; Bura, S. Andreea, 1978-; Kieffer, Brigitte L.; Maldonado, Rafael, 1961- (Nature Publishing Group, 2012)
    Multiple studies in animal models and humans suggest that the endogenous opioid system is an important neurobiological substrate for nicotine addictive properties. In this study, we evaluated the participation of δ-opioid ...
  • Involvement of the orexin/hypocretin system in the pharmacological effects induced by Δ(9)-tetrahydrocannabinol
    Flores de los Heros, África, 1985-; Julià Hernández, Marina; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Wiley, 2016)
    BACKGROUND AND PURPOSE: Anatomical, biochemical and pharmacological evidence suggest the existence of a crosstalk between the orexinergic and endocannabinoid systems. While the orexin receptor 1 (OX1 receptor) modulates ...
  • Orexins and fear: implications for the treatment of anxiety disorders
    Flores de los Heros, África, 1985-; Saravia Santos, Rocio, 1988-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2015)
    An understanding of the neurobiological mechanisms involved in the regulation of fear is essential for the development of new treatments for anxiety disorders, such as phobias, panic, and post-traumatic stress disorders ...
  • PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus
    Velasco, Eric R.; Florido Torres, Antonio Luis; Flores de los Heros, África, 1985-; Senabre, Eric; Gómez-Gómez, Àlex; Torres, Antoni; Roca, Antoni; Norrholm, Seth; Newman, Emily L.; Das, Payel; Ross, Rachel A.; Lori, A.; Pozo Mendoza, Óscar J., 1975-; Ressler, Kerry J.; Garcia-Esteve, Lluïsa; Jovanovic, Tanja; Andero, Raül (Nature Research, 2022)
    Exposure to traumatic stress can lead to fear dysregulation, which has been associated with posttraumatic stress disorder (PTSD). Previous work showed that a polymorphism in the PACAP-PAC1R (pituitary adenylate cyclase-activating ...
  • Role of β4* nicotinic acetylcholine receptors in the habenulo-interpeduncular pathway in nicotine reinforcement in mice.
    Harrington, Lauriane; Viñals Álvarez, Xavier, 1985-; Herrera Solís, Andrea; Flores de los Heros, África, 1985-; Morel, Carole; Tolu, Stefania; Faure, Philippe; Maldonado, Rafael, 1961-; Maskos, Uwe; Robledo, Patricia, 1958- (Nature Publishing Group, 2016)
    Nicotine exerts its psychopharmacological effects by activating the nicotinic acetylcholine receptor (nAChR), composed of alpha and/or beta subunits, giving rise to a diverse population of receptors with a distinct ...
  • THC exposure during adolescence does not modify nicotine reinforcing effects and relapse in adult male mice
    Flores de los Heros, África, 1985-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Springer, 2020)
    Rationale: Cannabis use is typically initiated during adolescence, and different studies suggest that adolescent cannabinoid exposure may increase the risk for drug addiction in adulthood. Objectives: This study investigated ...
  • The hypocretin/orexin receptor-1 as a novel target to modulate cannabinoid reward
    Flores de los Heros, África, 1985-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2014)
    BACKGROUND: Cannabis is the most widely used illicit drug in the world. Although there is a high prevalence of users who seek treatment for cannabis dependence, no accepted pharmacologic treatment is available to facilitate ...
  • The hypocretin/orexin system mediates the extinction of fear memories
    Flores de los Heros, África, 1985-; Valls Comamala, Victòria, 1987-; Costa, Giulia; Saravia Santos, Rocio, 1988-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Nature Publishing Group, 2014)
    Anxiety disorders are often associated with an inability to extinguish learned fear responses. The hypocretin/orexin system is involved in the regulation of emotional states and could also participate in the consolidation ...
  • When orexins meet cannabinoids: Bidirectional functional interactions
    Berrendero Díaz, Fernando, 1971-; Flores de los Heros, África, 1985-; Robledo, Patricia, 1958- (Elsevier, 2018)
    A growing body of evidence suggests the existence of biochemical and functional interactions between the endocannabinoid and orexin systems. Cannabinoid and orexin receptors have been shown to form heterodimers in agreement ...

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