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A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial

Farràs Mañé, Marta; Arranz, Sara; Carrión, Sílvia; Subirana Cachinero, Isaac; Muñoz-Aguayo, D.; Blanchart, Gemma; Kool, Marjon; Solà, Rosa; Motilva, Maria-José; Escolà-Gil, Joan Carles; Rubió, Laura; Fernández-Castillejo, Sara; Pedret, Anna; Estruch, Ramón; Covas Planells, Maria Isabel; Fitó Colomer, Montserrat; Hernáez, Álvaro; Castañer, Olga (MDPI, 2019)

The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) ...
A lower olfactory capacity is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body Mass index in women.

Pastor, Antonio; Fernández Aranda, Fernando; Fitó Colomer, Montserrat; Jiménez Murcia, Susana; Botella, Cristina; Fernández Real, Jose M.; Frühbeck, Gema; Tinahones Madueño, Francisco José; Fagundo, Ana B.; Rodríguez Rodríguez, Juan Francisco; Agüera, Zaida; Langohr, Klaus; Casanueva, Felipe F.; Torre Fornell, Rafael de la (Public Library of Science , 2016)

The endocannabinoid (eCB) system can promote food intake by increasing odor detection in mice. The eCB system is over-active in human obesity. Our aim is to measure circulating eCB concentrations and olfactory capacity in ...
A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women

Storniolo, Carolina Emilia; Casillas, Rosario; Bulló, Mònica; Castañer, Olga; Ros, Emilio; Sáez, Guillermo; Toledo, Estefania; Estruch, Ramón; Ruiz-Gutiérrez, Valentina; Fitó Colomer, Montserrat; Martínez-González, Miguel A.; Salas-Salvadó, Jordi; Mitjavila, María Teresa; Moreno, Juan José (Springer, 2017)

PURPOSE: Serum nitric oxide (NO) reduction and increased endothelin-1 (ET-1) play a pivotal role in endothelial dysfunction and hypertension. Considering that traditional Mediterranean diet (TMD) reduces blood pressure ...
A phase 1, randomized double-blind, placebo controlled trial to evaluate safety and efficacy of epigallocatechin-3-gallate and cognitive training in adults with Fragile X syndrome

Torre Fornell, Rafael de la; De Sola Llopis, Susana; Xicota Vila, Laura, 1987-; Cuenca Royo, Aida Ma, 1981-; Rodriguez, Joan; Gomis González, Maria, 1988-; Hernández, Gimena; Del Hoyo Soriano, Laura; Ozaita Mintegui, Andrés, 1969-; Dierssen, Mara; TESXF Study Group; Principe, Alessandro; Espadaler, Josep María; Roca, Laia; Del Hoyo Soriano, Laura; Farré Albaladejo, Magí; Fitó Colomer, Montserrat; León Jorba, Alba; Banea, Ovideo; Maldonado, Rafael, 1961-; Busquets Garcia, Arnau, 1985- (Elsevier, 2020)

Background & aims: Despite the wide spectrum of experimental compounds tested in clinical trials, there is still no proven pharmacological treatment available for Fragile-X syndrome (FXS), since several targeted clinical ...
Adopting a high-polyphenolic diet is associated with an improved glucose profile: Prospective analysis within the PREDIMED-Plus trial

Tresserra-Rimbau, Anna; Fitó Colomer, Montserrat; Castañer, Olga; López Grau, Mercè; Vila Vergaz, Manel; Salas-Salvadó, Jordi (MDPI, 2022)

Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a ...
Advances in integrating traditional and omic biomarkers when analyzing the effects of the mediterranean diet intervention in cardiovascular prevention.

Fitó Colomer, Montserrat; Melander, Olle; Martínez, José Alfredo; Toledo, Estefania; Carpéné, Christian; Corella, Dolores (MDPI, 2016)

Intervention with Mediterranean diet (MedDiet) has provided a high level of evidence in primary prevention of cardiovascular events. Besides enhancing protection from classical risk factors, an improvement has also been ...
Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals

Parri, Alejandra; Fitó Colomer, Montserrat; Torres, C. F.; Muñoz-Aguayo, D.; Schröder, Helmut, 1958-; Cano, J. F.; Vázquez, Luis Alberto; Reglero, G.; Covas Planells, Maria Isabel (Elsevier, 2016)

Alkylglycerols (AKGs), isolated or present in shark liver oil have anti-inflammatory properties. Complement 3 (C3) and 4 (C4) participate in lipid metabolism and in obesity, contributing to the metabolic syndrome and to ...
American Heart Association's life simple 7 and the risk of atrial fibrillation in the PREDIMED study cohort

Díaz-Gutiérrez, Jesús; Martínez-González, Miguel A.; Alonso, Alvaro; Toledo, Estefania; Salas-Salvadó, Jordi; Sorlí, José Vicente; Ros, Emilio; Fitó Colomer, Montserrat; Estruch, Ramón; Arós, Fernando; Fiol, Miquel; Lapetra, José; Gómez-Gracia, Enrique; Serra-Majem, Luis; Pintó Sala, Xavier; Portolés, Olga; Babio, Nancy; Castañer, Olga; Ruiz-Canela, Miguel (Elsevier, 2023)

Background and aims: The American Heart Association proposed 7 ideal cardiovascular health metrics (Life's Simple 7 [LS7]) namely, not smoking, body mass index <25 kg/m2, healthy diet, moderate physical activity ≥150 ...
Analysis of free hydroxytyrosol in human plasma following the administration of olive oil.

Pastor, Antonio; Rodríguez-Morató, Jose, 1987-; Olesti Muñoz, Eulàlia, 1991-; Pujadas Bastardes, Mitona; Pérez Mañá, Clara; Khymenets, Olha, 1974-; Fitó Colomer, Montserrat; Covas Planells, Maria Isabel; Solà, Rosa; Motilva, Maria-José; Farré Albaladejo, Magí; Torre Fornell, Rafael de la (Elsevier, 2016)

Hydroxytyrosol (HT) from olive oil, a potent bioactive molecule with health benefits, has a poor bioavailability, its free form (free HT) being undetectable so far. This fact leads to the controversy whether attained HT ...
Anthropometric variables as mediators of the association of changes in diet and physical activity with inflammatory profile

Cárdenas Fuentes, Gabriela, 1985-; Lassale, Camille; Martínez-González, Miguel A.; Grau Magaña, Maria; Salas Salvadó, Jordi; Corella, Dolores; Serra Majem, Lluís; Warnberg, Julia; Konieczna, Jadwiga; Estruch, Ramón; Pintó Sala, Xavier; Martínez, José Alfredo; Vázquez, Clotilde; Vidal Alaball, Josep; Tur, J. Antoni; Díaz López, Andrés; Lancova, Hana; Fitó Colomer, Montserrat; Schröder, Helmut, 1958- (Oxford University Press, 2021)

Background: Mechanisms underlying the associations of high levels of physical activity (PA) and adherence to the Mediterranean Diet (MedDiet) with a better inflammatory profile remain unclear. Our objective was to assess ...
Arginine catabolism metabolites and atrial fibrillation or heart failure risk: 2 case-control studies within the Prevención con Dieta Mediterránea (PREDIMED) trial

Goni, Leticia; Fitó Colomer, Montserrat; Ruiz-Canela, Miguel (Elsevier, 2022)

Background Arginine-derived metabolites are involved in oxidative and inflammatory processes related to endothelial functions and cardiovascular risks. Objectives We prospectively examined the associations of arginine ...
Asociación entre índice tobillo-brazo y rendimiento cognitivo en participantes del estudio PREDIMED-Plus: estudio transversal

López, Meritxell; Fitó Colomer, Montserrat; Gaforio, José J.; González-Palacios, Sandra; Cuenca Royo, Aida Ma, 1981-; Castañer, Olga; Yáñez, Aina M. (Elsevier, 2021)

Introducción y objetivos: El índice tobillo-brazo (ITB) es un indicador de enfermedad arterial periférica (EAP). El objetivo de este estudio es evaluar la asociación entre la EAP medida con el ITB y el rendimiento cognitivo ...
Association between dietary fibre intake and fruit, vegetable or whole-grain consumption and the risk of CVD: results from the PREvención con DIeta MEDiterránea (PREDIMED) trial

Buil-Cosiales, Pilar; Fitó Colomer, Montserrat; PREDIMED investigators (Cambridge University Press, 2016)

Prospective studies assessing the association between fibre intake or fibre-rich food consumption and the risk of CVD have often been limited by baseline assessment of diet. Thus far, no study has used yearly repeated ...
Association between lifestyle and hypertriglyceridemic waist phenotype in the PREDIMED-Plus study

Fernández García, José C.; Fitó Colomer, Montserrat; PREDIMED-PLUS investigators (Wiley, 2020)

Objective: The hypertriglyceridemic waist (HTGW) phenotype is characterized by abdominal obesity and high levels of triglycerides. In a cross-sectional assessment of PREDIMED-Plus trial participants at baseline, HTGW ...
Association between meal frequency and weight status in Spanish children: a prospective cohort study

Juton, Charlotte; Berruezo, Paula; Torres, Silvia; Castañer, Olga; Según, G.; Fitó Colomer, Montserrat; Homs, Clara; Gómez, Santiago Felipe; Schröder, Helmut (MDPI, 2023)

Childhood obesity is a major international problem, and unhealthy eating habits remain widespread. Increasing the frequency of meals of nutritious food can help children to regulate their appetite and maintain a healthy ...
Association between the 2018 WCRF/AICR and the low-risk lifestyle scores with colorectal cancer risk in the Predimed Study

Barrubés, Laura; Babio, Nancy; Hernández-Alonso, Pablo; Toledo, Estefania; Estruch, Ramón; Ros, Emilio; Fitó Colomer, Montserrat; Alonso-Gómez, Ángel; Fiol, Miquel; Lapetra, José; Serra-Majem, Luis; Pintó Sala, Xavier; Ruiz-Canela, Miguel; Corella, Dolores; Castañer, Olga; Macías-González, Manuel; Salas-Salvadó, Jordi (MDPI, 2020)

Limited longitudinal studies have been conducted to evaluate colorectal cancer (CRC) incidence based on the updated 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations or other ...
Association between the potential influence of a lifestyle intervention in older individuals with excess weight and metabolic syndrome on untreated household cohabitants and their family support: the PREDIMED-Plus Study

Basora, Josep; Villalobos, Felipe; Pallejà-Millán, Meritxell; Babio, Nancy; Goday Arno, Alberto; Castañer, Olga; Fitó Colomer, Montserrat; Zomeño Fajardo, Maria Dolores; Pintó Sala, Xavier; Sacanella, Emilio; Paz-Graniel, Indira; Salas Salvadó, Jordi (MDPI, 2020)

This cross-sectional study aims to evaluate the association between the PREDIMED-Plus study lifestyle intervention and (i) adherence to the Mediterranean diet (MedDiet) and (ii) physical activity of cohabiting study ...
Association between ultra-processed food consumption and gut microbiota in senior subjects with overweight/obesity and metabolic syndrome

Atzeni, Alessandro; Martínez, María Ángeles; Babio, Nancy; Konstanti, Prokopis; Tinahones Madueño, Francisco José; Vioque, Jesus; Corella, Dolores; Fitó Colomer, Montserrat; Vidal Alaball, Josep; Moreno Indias, Isabel; Pertusa-Martinez, Salvador; Álvarez-Sala, Andrea; Castañer, Olga; Goday Arno, Alberto; Damas-Fuentes, Miguel; Belzer, Clara; Martínez-González, Miguel A.; Hu, Frank B.; Salas Salvadó, Jordi (Frontiers, 2022)

The production and consumption of ultra-processed foods (UPF) has increased considerably during the last years worldwide. Collective evidence shows the association between UPF consumption and adverse health outcomes, ...
Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: the REGICOR Study

Dégano, Irene R.; Camps-Vilaró, Anna; Subirana Cachinero, Isaac; García-Mateo, Nadia; Cidad, Pilar; Muñoz Aguayo, Daniel; Puigdecanet Riubugent, Eulàlia; Nonell Mazelón, Lara; Vila, Joan; Crepaldi, Felipe M.; Gonzalo-Calvo, David de; Llorente-Cortés, Vicenta; Pérez García, María Teresa; Elosua Llanos, Roberto; Fitó Colomer, Montserrat; Marrugat de la Iglesia, Jaume (MDPI, 2020)

Risk prediction tools cannot identify most individuals at high coronary artery disease (CAD) risk. Oxidized low-density lipoproteins (oxLDLs) and microRNAs are actively involved in atherosclerosis. Our aim was to examine ...
Association of diet quality with dietary inflammatory potential in youth

Bawaked, Rowaedh Ahmed, 1985-; Schröder, Helmut, 1958-; Ribas-Barba, Lourdes; Izquierdo-Pulido, Maria; Pérez-Rodrigo, Carmen; Fitó Colomer, Montserrat; Serra-Majem, Luis (Taylor & Francis (Routledge), 2017)

Background: Diet plays a crucial role in the regulation of chronic inflammation. The sparse evidence available in adult populations indicates that diet quality is linked to the dietary inflammatory potential; however, this ...