Browsing by Author "Ferrer, Isidre"

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  • A highly expressed miR-101 isomiR is a functional silencing small RNA
    Llorens, Franc; Bañez Coronel, Mónica; Pantano Rubiño, Lorena, 1982-; del Río, José Antonio; Ferrer, Isidre; Estivill, Xavier, 1955-; Martí, Eulàlia (BioMed Central, 2013)
    Background: MicroRNAs (miRNAs) are short non-coding regulatory RNAs that control gene expression usually producing translational repression and gene silencing. High-throughput sequencing technologies have revealed heterogeneity ...
  • Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability
    Matamoros-Angles, Andreu; Hervera, Arnau; Soriano, Jordi; Martí, Eugènia; Carulla, Patricia; Llorens, F.; Nuvolone, Mario; Aguzzi, Adriano; Ferrer, Isidre; Gruart, Agnès; Delgado García, José María; del Río, José Antonio (BioMed Central, 2022)
    Background: Cellular prion protein (PrPC) is a cell surface GPI-anchored protein, usually known for its role in the pathogenesis of human and animal prionopathies. However, increasing knowledge about the participation of ...
  • Atypical astroglial pTDP-43 pathology in astroglial predominant tauopathy
    Gelpi, Ellen; Aldecoa, Iban; López Villegas, Dolores; Abellan-Vidal, María Teresa; Mercadel Fañanas, Pilar; Fortea, Juan; Ribosa, Roser; Morenas-Rodriguez, Estrella; Gómez Anson, Beatriz; Molina Porcel, Laura; Ximelis, Teresa; Borrego-Ecija, Sergi; Antonell Boixader, Anna; Rovelet Lecrux, Anne; Klotz, Sigrid; Andrés Benito, Pol; Sánchez Valle, Raquel; Ferrer, Isidre (Wiley, 2021)
    We observed atypical astrocytic pTDP-43 pathology in astroglial predominant tauopathy.
  • Cannabinoid receptor 2 participates in amyloid-β processing in a mouse model of Alzheimer's disease but plays a minor role in the therapeutic properties of a cannabis-based medicine
    Aso Pérez, Ester; Andrés Benito, Pol; Carmona, Margarita; Maldonado, Rafael, 1961-; Ferrer, Isidre (IOS Press, 2016)
    The endogenous cannabinoid system represents a promising therapeutic target to modify neurodegenerative pathways linked to Alzheimer's disease (AD). The aim of the present study was to evaluate the specific contribution ...
  • Cannabis-based medicine reduces multiple pathological processes in AβPP/PS1 mice
    Aso Pérez, Ester; Sánchez Pla, Alexandre; Vegas Lozano, Esteban; Maldonado, Rafael, 1961-; Ferrer, Isidre (IOS Press, 2015)
    Several recent findings suggest that targeting the endogenous cannabinoid system can be considered as a potential therapeutic approach to treat Alzheimer's disease (AD). The present study supports this hypothesis demonstrating ...
  • CB1 agonist ACEA protects neurons and reduces the cognitive impairment of AβPP/PS1 mice
    Aso Pérez, Ester; Palomer, Ernest; Juvés, Salvador; Maldonado, Rafael, 1961-; Muñoz López, Francisco José, 1964-; Ferrer, Isidre (IOS Press, 2012)
    The present study shows that chronic administration of the cannabinoid receptor type 1 (CB1) receptor agonist arachidonyl-2-chloroethylamide (ACEA) at pre-symptomatic or at early symptomatic stages, at a non-amnesic dose, ...
  • CB2 cannabinoid receptor agonist ameliorates Alzheimer-like phenotype in AβPP/PS1 mice
    Aso Pérez, Ester; Juvés, Salvador; Maldonado, Rafael, 1961-; Ferrer, Isidre (IOS Press, 2013)
    The specific CB2 cannabinoid receptor agonist JWH-133 induced cognitive improvement in double AβPP/PS1 transgenic mice, a genetic model of Alzheimer's disease. This effect was more pronounced when administered at the ...
  • DYRK1A-mediated phosphorylation of GluN2A at Ser1048 regulates the surface expression and channel activity of GluN1/GluN2A receptors
    Grau, Cristina; Arató, Krisztina, 1981-; Fernández-Fernández, José Manuel, 1967-; Valderrama, Aitana; Sindreu, Carlos; Fillat i Fonts, Cristina; Ferrer, Isidre; Luna, Susana de la; Altafaj, Xavier (Frontiers, 2014)
    N-methyl-D-aspartate glutamate receptors (NMDARs) play a pivotal role in neural development and synaptic plasticity, as well as in neurological disease. Since NMDARs exert their function at the cell surface, their density ...
  • Ecto-GPR37: a potential biomarker for Parkinson's disease
    Morató, Xavier; Garcia-Esparcia, Paula; Argerich, Josep; Llorens, Franc; Zerr, Inga; Paslawski, Wojciech; Borrás, Eva; Sabidó Aguadé, Eduard, 1981-; Petäjä-Repo, Ulla E.; Fernández-Dueñas, Víctor; Ferrer, Isidre; Svenningsson, Per; Ciruela, Francisco (BioMed Central, 2021)
    Objective: α-Synuclein has been studied as a potential biomarker for Parkinson's disease (PD) with no concluding results. Accordingly, there is an urgent need to find out reliable specific biomarkers for PD. GPR37 is an ...
  • Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns
    Sánchez Mut, Jose V.; Heyn, Holger; Vidal, Enrique; Moran, Sebastian; Sayols, Sergi; Delgado Morales, Raul; Schultz, Matthew D.; Ansoleaga, Belén; García Esparcia, Paula; Pons Espinal, Meritxell, 1986-; Martínez de Lagran, Maía; Dopazo, Jose M.; Rábano, Alberto; Ávila, Jesús; Dierssen, Mara; Lott, Ira T.; Ferrer, Isidre; Ecker, Joseph R.; Esteller, Manel (Nature Publishing Group, 2016)
    Different neurodegenerative disorders often show similar lesions, such as the presence of amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited forms are rare, so we wondered whether shared ...
  • Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance
    Fourcade, Stéphane; Morató, Laia; Parameswaran, Janani, 1990-; Ruiz, Montserrat; Ruiz Cortés, Tatiana; Jové, Mariona; Naudí, Alba; Martínez Redondo, Paloma; Dierssen, Mara; Ferrer, Isidre; Villarroya, Francesc; Pamplona, Reinald; Vaquero, Alejandro; Portero Otín, Manuel; Pujol, Aurora, 1968- (Wiley, 2018)
    Sirtuin 2 (SIRT2) is a member of a family of NAD+ -dependent histone deacetylases (HDAC) that play diverse roles in cellular metabolism and especially for aging process. SIRT2 is located in the nucleus, cytoplasm, and ...
  • Modulation of mitochondrial and inflammatory homeostasis through RIP140 is neuroprotective in an adrenoleukodystrophy mouse model
    Ranea-Robles, Pablo; Galino, Jorge; Espinosa Blay, Lluís; Schlüter, Agatha; Ruiz, Montserrat; Calingasan, Noel Ylagan; Villarroya, Francesc; Naudí, Alba; Pamplona, Reinald; Ferrer, Isidre; Beal, M. Flint; Portero Otín, Manuel; Fourcade, Stéphane; Pujol, Aurora, 1968- (Wiley, 2022)
    Aims: Mitochondrial dysfunction and inflammation are at the core of axonal degeneration in several multifactorial neurodegenerative diseases, including multiple sclerosis, Alzheimer's disease, and Parkinson's disease. The ...
  • Patient-specific iPSC-derived astrocytes contribute to non-cell-autonomous neurodegeneration in Parkinson's disease
    di Domenico, Angelique; Carola, Giulia; Calatayud, Carles; Pons Espinal, Meritxell, 1986-; Muñoz, Juan Pablo; Richaud Patin, Yvonne; Fernández Carasa, Irene; Gut, Marta; Faella, Armida; Parameswaran, Janani, 1990-; Soriano, Jordi; Ferrer, Isidre; Tolosa, Eduard; Zorzano, Antonio; Cuervo, Ana Maria; Raya Chamorro, Ángel; Consiglio, Antonella (Elsevier, 2019)
    Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A non-cell-autonomous contribution, in particular of astrocytes, ...
  • Regional and subtype-dependent miRNA signatures in sporadic Creutzfeldt-Jakob disease are accompanied by alterations in miRNA silencing machinery and biogenesis
    Llorens, Franc; Thüne, Katrin; Martí Puig, Eulàlia; Kanata, Eirini; Dafou, Dimitra; Díaz Lucena, Daniela; Vivancos Prellezo, Ana; Shomroni, Orr; Zafar, Saima; Schmitz, Matthias; Michel, Uwe; Fernández Borges, Natalia; Andreóletti, Olivier; del Río, José Antonio; Díez Antón, Juana, 1962-; Fischer, André; Bonn, Stefan; Sklaviadis, Theodoros K.; Torres, Juan María; Ferrer, Isidre; Zerr, Inga (Public Library of Science (PLoS), 2018)
    Increasing evidence indicates that microRNAs (miRNAs) are contributing factors to neurodegeneration. Alterations in miRNA signatures have been reported in several neurodegenerative dementias, but data in prion diseases are ...
  • Smelling the dark proteome: functional characterization of PITH domain-containing protein 1 (C1orf128) in olfactory metabolism
    Lachén Montes, Mercedes; Mendizuri, Naroa; Ausín, Karina; Pérez Mediavilla, Alberto; Azkargorta, Mikel; Iloro, Ibon; Elortza, Félix; Kondo, Hiroyuki; Ohigashi, Izumi; Ferrer, Isidre; Torre Fornell, Rafael de la; Robledo, Patricia, 1958-; Fernández Irigoyen, Joaquín; Santamaría, Enrique (American Chemical Society (ACS), 2020)
    The Human Proteome Project (HPP) consortium aims to functionally characterize the dark proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have analyzed the dark proteome using data mining ...
  • The presence of human herpesvirus 6 in the brain in health and disease
    Santpere Baró, Gabriel, 1981-; Telford, Marco, 1984-; Andrés Benito, Pol; Navarro i Cuartiellas, Arcadi, 1969-; Ferrer, Isidre (MDPI, 2020)
    The human herpesvirus 6 (HHV-6) -A and -B are two dsDNA beta-herpesviruses infectingalmost the entire worldwide population. These viruses have been implicated in multipleneurological conditions in individuals of various ...