Browsing by Author "Ferrari, Roberto"

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  • A set of accessible enhancers enables the initial response of breast cancer cells to physiological progestin concentrations
    Zaurín Quer, Roser; Ferrari, Roberto; Nacht, A. Silvina; Carbonell-Caballero, Jose; Le Dily, François; Font Mateu, Jofre, 1977-; De Llobet, Lara Isabel; Vidal Ocabo, Enrique; Lioutas, Antonio, 1980-; Beato, Miguel; Vincent, Guillermo P. (Oxford University Press, 2021)
    Here, we report that in T47D breast cancer cells 50 pM progestin is sufficient to activate cell cycle entry and the progesterone gene expression program. At this concentration, equivalent to the progesterone blood levels ...
  • Abf1 and other general regulatory factors control ribosome biogenesis gene expression in budding yeast
    Bosio, Maria Cristina; Fermi, Beatrice; Spagnoli, Gloria; Levati, Elisabetta; Rubbi, Liudmilla; Ferrari, Roberto; Pellegrini, Matteo; Dieci, Giorgio (Oxford University Press, 2017)
    Ribosome biogenesis in Saccharomyces cerevisiae involves a regulon of >200 genes (Ribi genes) coordinately regulated in response to nutrient availability and cellular growth rate. Two cis-acting elements called PAC and ...
  • An RNA polymerase III general transcription factor engages in cell type-specific chromatin looping
    De Llobet, Lara Isabel; Di Vona, Chiara, 1981-; Morselli, Marco; Vezzoli, Marco; Montanini, Barbara; Teichmann, Martin; de la Luna, Susana; Ferrari, Roberto (MDPI, 2022)
    Transcription factors (TFs) bind DNA in a sequence-specific manner and are generally cell type-specific factors and/or developmental master regulators. In contrast, general TFs (GTFs) are part of very large protein complexes ...
  • C/EBPα mediates the growth inhibitory effect of progestins on breast cancer cells
    Nacht, A. Silvina; Ferrari, Roberto; Zaurín Quer, Roser; Scabia, Valentina; Carbonell-Caballero, Jose; Le Dily, François; Quilez Oliete, Javier; Leopoldi, Alexandra; Brisken, Cathrin; Beato, Miguel; Vicent, Guillermo Pablo (EMBO Press, 2019)
    Steroid hormones are key gene regulators in breast cancer cells. While estrogens stimulate cell proliferation, progestins activate a single cell cycle followed by proliferation arrest. Here, we use biochemical and genome-wide ...
  • Hormone-control regions mediate steroid receptor-dependent genome organization
    Le Dily, François; Vidal, Enrique; Cuartero, Yasmina; Quilez Oliete, Javier; Nacht, A. Silvina; Vicent, Guillermo Pablo; Carbonell-Caballero, Jose; Sharma, Priyanka; Villanueva Cañas, José Luis, 1984-; Ferrari, Roberto; De Llobet, Lara Isabel; Verde, Gaetano; Wright, Roni H.G.; Beato, Miguel (Cold Spring Harbor Laboratory Press (CSHL Press), 2019)
    In breast cancer cells, some topologically associating domains (TADs) behave as hormonal gene regulation units, within which gene transcription is coordinately regulated in response to steroid hormones. Here we further ...
  • TFIIIC as a potential epigenetic modulator of histone acetylation in human stem cells
    Vezzoli, Marco; De Llobet, Lara Isabel; Di Vona, Chiara, 1981-; Morselli, Marco; Montanini, Barbara; Luna Gargantilla, Susana de la; Teichmann, Martin; Dieci, Giorgio; Ferrari, Roberto (MDPI, 2023)
    Regulation of histone acetylation dictates patterns of gene expression and hence cell identity. Due to their clinical relevance in cancer biology, understanding how human embryonic stem cells (hESCs) regulate their genomic ...
  • TFIIIC binding to alu elements controls gene expression via chromatin looping and histone acetylation
    Ferrari, Roberto; De Llobet, Lara Isabel; Di Vona, Chiara, 1981-; Le Dily, François; Vidal Ocabo, Enrique; Lloutas, Antonios; Quilez Oliete, Javier; Jochem, Laura; Cuts, Erin; Dieci, Giorgio; Vannini, Alessandro; Teichmann, Martin; de la Luna, Susana; Beato, Miguel (Elsevier, 2020)
    How repetitive elements, epigenetic modifications, and architectural proteins interact ensuring proper genome expression remains poorly understood. Here, we report regulatory mechanisms unveiling a central role of Alu ...