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Browsing by Author "Fernández-Fernández, José Manuel, 1967-"
Now showing items 1-20 of 27
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Picón-Pagès, Pol; Bosch Morató, Mònica, 1986-; Subirana, Laia; Rubio-Moscardó, Francisca; Guivernau Almazán, Biuse, 1988-; Fanlo-Ucar, Hugo; Zeylan, Melisa Ece; Senyuz, Simge; Herrera-Fernández, Víctor; Vicente García, Rubén, 1978-; Fernández-Fernández, José Manuel, 1967-; García Ojalvo, Jordi; Gursoy, Attila; Keskin, Ozlem; Oliva Miguel, Baldomero; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de; Muñoz López, Francisco José, 1964- (MDPI, 2023)Alzheimer's disease (AD) is known to be caused by amyloid β-peptide (Aβ) misfolded into β-sheets, but this knowledge has not yet led to treatments to prevent AD. To identify novel molecular players in Aβ toxicity, we carried ...
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Bahamonde Santos, María Isabel, 1972-; Serra Pascual, Selma A., 1981-; Drechsel, Oliver; Rahman, Rubayte; Marcé-Grau, Anna; Prieto, Marta; Ossowski, Stephan; Macaya, Alfons; Fernández-Fernández, José Manuel, 1967- (Public Library of Science (PLoS), 2015)Mutations in the CACNA1A gene, encoding the pore-forming CaV2.1 (P/Q-type) channel α1A subunit, result in heterogeneous human neurological disorders, including familial and sporadic hemiplegic migraine along with episodic ...
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Walsh Capdevila, Sandra, 1991-; Izquierdo Serra, Mercè; Acosta, Sandra; Edo, Albert; Lloret, María; Moret, Roser; Bosch Fusté, Elena; Oliva Miguel, Baldomero; Bertranpetit, Jaume, 1952-; Fernández-Fernández, José Manuel, 1967- (Nature Research, 2020)TRPP3 (also called PKD2L1) is a nonselective, cation-permeable channel activated by multiple stimuli, including extracellular pH changes. TRPP3 had been considered a candidate for sour sensor in humans, due to its high ...
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Martín, Pedro; Moncada, Melisa; Castillo, Karen; Orsi, Federico; Ducca, Gerónimo; Fernández-Fernández, José Manuel, 1967-; González, Carlos; Milesi, Verónica (Elsevier, 2021)Arachidonic acid (AA) is a fatty acid involved in the modulation of several ion channels. Previously, we reported that AA activates the high conductance Ca2+- and voltage-dependent K+ channel (BK) in vascular smooth muscle ...
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Garcia-Elias Heras, Anna; Tajes Orduña, Marta; Yañez Bisbe, Laia; Enjuanes Grau, Cristina; Comín Colet, Josep; Serra, Selma A.; Fernández-Fernández, José Manuel, 1967-; Aguilar-Agon, Kathryn W.; Reilly, Svetlana; Martí Almor, Julio; Benito Villabriga, Begoña (MDPI, 2021)MicroRNAs (miRNAs) participate in atrial remodeling and atrial fibrillation (AF) promotion. We determined the circulating miRNA profile in patients with AF and heart failure with reduced ejection fraction (HFrEF), and its ...
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Haley, Jane E.; Abogadie, Fe C.; Fernández-Fernández, José Manuel, 1967-; Dayrell, Mariza; Vallis, Yvonne; Buckley, Noel J.; Brown, David A. (Society for Neuroscience, 2000)Rat superior cervical ganglion (SCG) neurons express low-threshold noninactivating M-type potassium channels (I-K(M)), which can be inhibited by activation of M-1 muscarinic receptors (M-1 mAChR) and bradykinin (BK) B-2 ...
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Martínez Monseny, Antonio Federico; Edo, Albert; Casas Alba, Dídac; Izquierdo Serra, Mercè; Bolasell, Mercè; Conejo, David; Martorell, Loreto; Muchart, Jordi; Carrera, Laura; Ortez, Carlos; Nascimento, Andrés; Oliva Miguel, Baldomero; Fernández-Fernández, José Manuel, 1967-; Serrano Masip, Mercedes (MDPI, 2021)The CACNA1A gene encodes the pore-forming α1A subunit of the voltage-gated CaV2.1 Ca2+ channel, essential in neurotransmission, especially in Purkinje cells. Mutations in CACNA1A result in great clinical heterogeneity with ...
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Serra Pascual, Selma A., 1981- (Universitat Pompeu Fabra, 2011-07-04)Migraine is one of most disabling neurological disorders for which the genetic and molecular mechanisms are not fully resolved. This PhD thesis has focused on the functional characterization of two new missense mutations ...
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Galindo Guarín, Liliana; Moreno, Estefanía; López-Armenta, Fernando; Guinart, Dani; Cuenca Royo, Aida Ma, 1981-; Izquierdo Serra, Mercè; Xicota Vila, Laura, 1987-; Fernandez, Cristina; Menoyo Colomer, Esther; Fernández-Fernández, José Manuel, 1967-; Benítez-King, Gloria; Canela, Enric I.; Casadó, Vicent; Pérez Solá, Victor; Torre Fornell, Rafael de la; Robledo, Patricia, 1958- (Springer, 2018)Cannabinoid CB1 receptors (CB1R) and serotonergic 2A receptors (5HT2AR) form heteromers in the brain of mice where they mediate the cognitive deficits produced by delta-9-tetrahydrocannabinol. However, it is still unknown ...
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Serra Pascual, Selma A., 1981-; Gené, Gemma; Elorza Vidal, Xabier; Fernández-Fernández, José Manuel, 1967- (Wiley, 2018)Modulation of CaV 2.1 channel activity plays a key role in interneuronal communication and synaptic plasticity. SNAREs interact with a specific synprint site at the second intracellular loop (LII-III) of the CaV 2.1 ...
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Grau, Cristina; Arató, Krisztina, 1981-; Fernández-Fernández, José Manuel, 1967-; Valderrama, Aitana; Sindreu, Carlos; Fillat i Fonts, Cristina; Ferrer, Isidre; Luna, Susana de la; Altafaj, Xavier (Frontiers, 2014)N-methyl-D-aspartate glutamate receptors (NMDARs) play a pivotal role in neural development and synaptic plasticity, as well as in neurological disease. Since NMDARs exert their function at the cell surface, their density ...
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Casas Alba, Dídac; López-Sala, Laura; Pérez-Ordóñez, Marta; Mari-Vico, Rosanna; Bolasell, Mercè; Martínez Monseny, Antonio Federico; Muchart, Jordi; Fernández-Fernández, José Manuel, 1967-; Martorell, Loreto; Serrano, Mercedes L. (Wiley, 2021)Early-onset severe spinocerebellar ataxia 42 with neurodevelopmental deficits (SCA42ND, MIM#604065) is an ultrarare autosomal dominant syndrome related to de novo CACNA1G gain-of-function pathogenic variants. All patients ...
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Fernández-Fernández, José Manuel, 1967-; Tomás Mestres, Marta; Vázquez Gómez, Esther; Orio, Patricio; Latorre, Ramón; Sentí Clapés, Mariano; Marrugat de la Iglesia, Jaume; Valverde, M. A. (Miguel Ángel), 1963- (American Society for Clinical Investigation, 2004)Hypertension is the most prevalent risk factor for cardiovascular diseases, present in almost 30% of adults. A key element in the control of vascular tone is the large-conductance, Ca(2+)-dependent K(+) (BK) channel. The ...
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Fernandes, Jacqueline; Lorenzo, Ivan M.; Andrade, Yaniré N.; Garcia-Elias Heras, Anna; Serra Pascual, Selma A., 1981-; Fernández-Fernández, José Manuel, 1967-; Valverde, M. A. (Miguel Ángel), 1963- (Rockefeller University Press, 2008)Mechanical and osmotic sensitivity of the transient receptor potential vanilloid 4 (TRPV4) channel depends on phospholipase A(2) (PLA(2)) activation and the subsequent production of the arachidonic acid metabolites, ...
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Solé, Laura; Roura Ferrer, Meritxell; Pérez Verdaguer, Mireia; Oliveras, Anna; Calvo, Maria; Fernández-Fernández, José Manuel, 1967-; Felipe, Antonio (Company of Biologists, 2009)Voltage-dependent potassium channels (Kv) play a crucial role in the activation and proliferation of leukocytes. Kv channels are either homo- or hetero-oligomers. This composition modulates their surface expression and ...
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Godoy Zeballos, Juan Alejandro, 1959-; Rios, Juvenal A.; Picón-Pagès, Pol; Herrera-Fernández, Víctor; Swaby, Bronte; Crepin, Giulia; Vicente García, Rubén, 1978-; Fernández-Fernández, José Manuel, 1967-; Muñoz López, Francisco José, 1964- (MDPI, 2021)Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic plasticity. Their functional integrity is ...
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Granja, Ricardo; Fernández-Fernández, José Manuel, 1967-; Izaguirre, Victor; González García, Carmen; Ceña, Valentin (Elsevier, 1995)We have studied the contribution of P-type voltage-dependent Ca2+ channels to both catacholamine (CA) and ATP secretion from bovine chromaffin cells induced by high K+ or nicotine using omega-agatoxin IVA, a selective ...
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Izquierdo Serra, Mercè; Fernández-Fernández, José Manuel, 1967-; Serrano, Mercedes (Springer, 2020)Human mutations in the CACNA1A gene that encodes the pore-forming α1A subunit of the voltage-gated CaV2.1 (P/Q-type) Ca2+ channel cause multiple neurological disorders including sporadic and familial hemiplegic migraine, ...
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Fernández Mariño, Ana Isabel, 1984- (Universitat Pompeu Fabra, 2013-07-29)The large-conductance Ca2+- and voltage-gated K+ (BK) channel containing the pore-forming and the regulatory B1 subunits play a pivotal role in the control of arterial tone and modification of channel function is associated ...
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Carrillo García, Julia, 1993- (2021-09-30)This project has aimed to investigate the regulation of the mechanosensitive ion channel Piezo1 by proteins that sense and modify membrane curvature. Our second objective has been to study this interplay in the context of ...
Now showing items 1-20 of 27
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