Browsing by Author "Fernández-Cadenas, Israel"

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  • Cárcel-Márquez, Jara; Jiménez Conde, Jordi; Roquer, Jaume; Fernández-Cadenas, Israel (Frontiers, 2022)
    Background: occult atrial fibrillation (AF) is one of the major causes of embolic stroke of undetermined source (ESUS). Knowing the underlying etiology of an ESUS will reduce stroke recurrence and/or unnecessary use of ...
  • Cullell, Natalia; Soriano Tarraga, Carolina; Gallego-Fabrega, Cristina; Cárcel-Márquez, Jara; Muiño, Elena; Llucià-Carol, Laia; Lledós, Miquel; Esteller, Manel; Castro de Moura, Manuel; Montaner, Joan; Rosell, Anna; Delgado, Pilar; Martí-Fàbregas, Joan; Krupinski, Jerzy; Roquer, Jaume; Jiménez Conde, Jordi; Fernández-Cadenas, Israel (BioMed Central, 2022)
    Background and purpose: the neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play ...
  • Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Mola Caminal, Marina; Ois Santiago, Angel Javier; Rodríguez-Campello, Ana; Cuadrado-Godia, Elisa; Fernández-Cadenas, Israel; Cullell, Natalia; Roquer, Jaume; Jiménez Conde, Jordi (Nature Research, 2018)
    Age and stroke severity are the main mortality predictors after ischemic stroke. However, chronological age and biological age are not exactly concordant. Age-related changes in DNA methylation in multiple CpG sites across ...
  • Gallego-Fabrega, Cristina; Cullell, Natalia; Soriano Tarraga, Carolina; Carrera, Caty; Torres-Aguila, Nuria P.; Muiño, Elena; Cárcel-Márquez, Jara; Castro de Moura, Manuel; Fernández Sanlés, Alba, 1988-; Esteller, Manel; Elosua Llanos, Roberto; Jiménez Conde, Jordi; Roquer, Jaume; Montaner, Joan; Krupinski, Jerzy; Fernández-Cadenas, Israel (Impact Journals, 2020)
    Background and purpose: Polymorphisms and serum levels of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) have been studied with regard to atheromatous plaques and ischemic stroke, while ...
  • Söderholm, Martin; Fernández-Cadenas, Israel; Jiménez Conde, Jordi; Jern, Christina; International Stroke Genetics Consortium; Genetics of Ischaemic Stroke Functional Outcome (GISCOME) Network (Wolters Kluwer (LWW), 2019)
    Objective: To discover common genetic variants associated with poststroke outcomes using a genome-wide association (GWA) study. Methods: The study comprised 6,165 patients with ischemic stroke from 12 studies in Europe, ...
  • Muiño, Elena; Rodríguez-Campello, Ana; Romeral, Gemma; Roquer, Jaume; Fernández-Cadenas, Israel (Nature Research, 2021)
    CADASIL is a small vessel disease caused by mutations in NOTCH3 that lead to an odd number of cysteines in the EGF-like repeat domain, causing protein misfolding and aggregation. The main symptoms are migraine, psychiatric ...
  • Lindgren, Arne G.; Jiménez Conde, Jordi; Fernández-Cadenas, Israel; International Stroke Genetics Consortium (SAGE Publications, 2022)
    Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke ...
  • Muiño, Elena; Gallego-Fabrega, Cristina; Cullell, Natalia; Carrera, Caty; Torres, Nuria; Krupinski, Jurek; Roquer, Jaume; Montaner, Joan; Fernández-Cadenas, Israel (MDPI, 2017)
    CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is caused by mutations in the NOTCH3 gene, affecting the number of cysteines in the extracellular domain of the receptor, ...
  • Carrera, Caty; Giralt-Steinhauer, Eva; Jiménez Conde, Jordi; Roquer, Jaume; Fernández-Cadenas, Israel; Spanish Stroke Genetic Consortium (Lippincott Williams & Wilkins, 2019)
    Objective: To validate the Genot-PA score, a clinical-genetic logistic regression score that stratifies the thrombolytic therapy safety, in a new cohort of patients with stroke. Methods: We enrolled 1,482 recombinant tissue ...

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