Browsing by Author "Fernández-Blanco, Álvaro"

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  • Müller glia fused with adult stem cells undergo neural differentiation in human retinal models
    Bonilla-Pons, Sergi A.; Nakagawa, Shoma; Garreta Bahima, Elena; Fernández-Blanco, Álvaro; Pesaresi, Martina, 1991-; D'Antin, Justin Christopher; Sebastian-Perez, Ruben; Greco, Daniela; Domínguez-Sala, Eduardo; Gómez-Riera, Raúl; Barraquer Compte, Rafael Ignacio; Dierssen, Mara; Montserrat Pulido, Núria; Cosma, Maria Pia (Elsevier, 2022)
    Background: Visual impairments are a critical medical hurdle to be addressed in modern society. Müller glia (MG) have regenerative potential in the retina in lower vertebrates, but not in mammals. However, in mice, in vivo ...
  • Proteomic profiling reveals mitochondrial dysfunction in the cerebellum of transgenic mice overexpressing DYRK1A, a Down syndrome candidate gene
    Ortega, Mireia; De Toma, Ilario; Fernández-Blanco, Álvaro; Calderón Moruno, Anna; Barahona, Lucía; Trullàs, Ramón; Sabidó Aguadé, Eduard, 1981-; Dierssen, Mara (Frontiers, 2022)
    Introduction: DYRK1A is a dual-specificity kinase that is overexpressed in Down syndrome (DS) and plays a key role in neurogenesis, neuronal differentiation and function, cognitive phenotypes, and aging. Dyrk1A has also ...
  • Rethinking intellectual disability from neuro- to astro-pathology
    Fernández-Blanco, Álvaro; Dierssen, Mara (MDPI, 2020)
    Neurodevelopmental disorders arise from genetic and/or from environmental factors and are characterized by different degrees of intellectual disability. The mechanisms that govern important processes sustaining learning ...