Browsing by Author "Fernández Real, Jose M."

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  • A lower olfactory capacity is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body Mass index in women.
    Pastor, Antonio; Fernández Aranda, Fernando; Fitó Colomer, Montserrat; Jiménez Murcia, Susana; Botella, Cristina; Fernández Real, Jose M.; Frühbeck, Gema; Tinahones Madueño, Francisco José; Fagundo, Ana B.; Rodríguez Rodríguez, Juan Francisco; Agüera, Zaida; Langohr, Klaus; Casanueva, Felipe F.; Torre Fornell, Rafael de la (Public Library of Science , 2016)
    The endocannabinoid (eCB) system can promote food intake by increasing odor detection in mice. The eCB system is over-active in human obesity. Our aim is to measure circulating eCB concentrations and olfactory capacity in ...
  • Adipose tissue coregulates cognitive function
    Oliveras Cañellas, Núria; Castells-Nobau, Anna; Vega-Correa, Lisset de la; Latorre-Luque, Jessica; Motger-Albertí, Anna; Arnoriaga Rodríguez, María; Garre-Olmo, Josep; Zapata-Tona, Cristina; Coll Martínez, Clàudia; Ramió-Torrentà, Lluís; Moreno-Navarrete, José Maria; Puig, Josep; Villarroya, Francesc; Ramos, Rafel; Casadó-Anguera, Verònica; Martín García, Elena, 1975-; Maldonado, Rafael, 1961-; Mayneris Perxachs, Jordi; Fernández Real, Jose M. (American Association for the Advancement of Science (AAAS), 2023)
    Obesity is associated with cognitive decline. Recent observations in mice propose an adipose tissue (AT)-brain axis. We identified 188 genes from RNA sequencing of AT in three cohorts that were associated with performance ...
  • An increase in visceral fat is associated with a decrease in the taste and olfactory capacity
    Fernandez-Garcia, Jose Carlos; Alcaide, Juan; Santiago-Fernandez, Concepcion; Roca-Rodriguez, M.M.; Agüera, Zaida; Baños, Rosa M.; Botella, Cristina; Torre Fornell, Rafael de la; Fernández Real, Jose M.; Frühbeck, Gema; Gómez Ambrosi, Javier; Jiménez Murcia, Susana; Menchón, José M.; Casanueva, Felipe F.; Fernández Aranda, Fernando; Tinahones Madueño, Francisco José; Garrido-Sanchez, Lourdes (Public Library of Science (PLoS), 2017)
    Introduction: Sensory factors may play an important role in the determination of appetite and food choices. Also, some adipokines may alter or predict the perception and pleasantness of specific odors. We aimed to analyze ...
  • Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index
    Pardo, María Luisa; Crujeiras, Ana B.; Amil, María; Agüera, Zaida; Jiménez Murcia, Susana; Baños, Rosa M.; Botella, Cristina; Torre Fornell, Rafael de la; Estivill, Xavier, 1955-; Fagundo, Ana B.; Fernández Real, Jose M.; Fernández García, José C.; Frühbeck, Gema; Gómez Ambrosi, Javier; Rodríguez, Roser; Tinahones Madueño, Francisco José; Fernández Aranda, Fernando; Casanueva, Felipe F. (Hindawi, 2014)
    FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also ...
  • Caudovirales bacteriophages are associated with improved executive function and memory in flies, mice, and humans
    Mayneris Perxachs, Jordi; Castells-Nobau, Anna; Arnoriaga Rodríguez, María; Garre-Olmo, Josep; Puig, Josep; Ramos, Rafel; Martínez Hernández, Francisco; Burokas, Aurelijus, 1982-; Coll, Clàudia; Moreno-Navarrete, José Maria; Zapata-Tona, Cristina; Pedraza, Salvador; Pérez Brocal, Vicente; Ramió-Torrentà, Lluís; Ricart, Wifredo; Moya, Andrés; Martínez García, Manuel; Maldonado, Rafael, 1961-; Fernández Real, Jose M. (Elsevier, 2022)
    Growing evidence implicates the gut microbiome in cognition. Viruses, the most abundant life entities on the planet, are a commonly overlooked component of the gut virome, dominated by the Caudovirales and Microviridae ...
  • Decision Making Impairment: A Shared Vulnerability in Obesity, Gambling Disorder and Substance Use Disorders?
    Mallorquí-Bagué, Nuria; Fagundo, Ana B.; Jiménez Murcia, Susana; Torre Fornell, Rafael de la; Baños, Rosa M.; Botella, Cristina; Casanueva, Felipe F.; Crujeiras, Ana B.; Fernández García, José C.; Fernández Real, Jose M.; Frühbeck, Gema; Granero, Roser; Rodríguez, Amaia; Tolosa-Sola, Iris; Ortega, Francesc; Tinahones Madueño, Francisco José; Alvarez-Moya, Eva; Ochoa, Cristian; Menchón, José M.; Fernández Aranda, Fernando (Public Library of Science (PLoS) , 2016)
    INTRODUCTION: Addictions are associated with decision making impairments. The present study explores decision making in Substance use disorder (SUD), Gambling disorder (GD) and Obesity (OB) when assessed by Iowa Gambling ...
  • Executive functions profile in extreme eating/weight conditions: from anorexia nervosa to obesity
    Fagundo, Ana B.; Torre Fornell, Rafael de la; Jiménez Murcia, Susana; Agüera, Zaida; Granero, Roser; Tárrega, Salomé; Botella, Cristina; Baños, Rosa M.; Fernández Real, Jose M.; Rodríguez, Roser; Forcano, Laura; Frühbeck, Gema; Gómez Ambrosi, Javier; Tinahones Madueño, Francisco José; Fernández García, José C.; Casanueva, Felipe F.; Fernández Aranda, Fernando (Public Library of Science (PLoS), 2012)
    Background: Extreme weight conditions (EWC) groups along a continuum may share some biological risk factors and intermediate neurocognitive phenotypes. A core cognitive trait in EWC appears to be executive dysfunction, ...
  • Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile
    Arnoriaga Rodríguez, María; Mayneris Perxachs, Jordi; Burokas, Aurelijus, 1982-; Pérez Brocal, Vicente; Moya, Andrés; Portero Otín, Manuel; Ricart, Wifredo; Maldonado, Rafael, 1961-; Fernández Real, Jose M. (BioMed Central, 2020)
    Background: The chaperone ClpB, a bacterial protein, is a conformational antigen-mimetic of α-melanocyte-stimulating hormone (α-MSH) implicated in body weight regulation in mice. We here investigated the potential associations ...
  • Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
    Mayneris Perxachs, Jordi; Arnoriaga Rodríguez, María; Luque-Córdoba, Diego; Priego-Capote, Feliciano; Pérez Brocal, Vicente; Moya, Andrés; Burokas, Aurelijus, 1982-; Maldonado, Rafael, 1961-; Fernández Real, Jose M. (BioMed Central, 2020)
    Background: Gonadal steroid hormones have been suggested as the underlying mechanism responsible for the sexual dimorphism observed in metabolic diseases. Animal studies have also evidenced a causal role of the gut microbiome ...
  • Microbiota alterations in proline metabolism impact depression
    Mayneris Perxachs, Jordi; Martin, Miquel; Burokas, Aurelijus, 1982-; Escrichs, Anira; Deco, Gustavo; Maldonado, Rafael, 1961-; Fernández Real, Jose M. (Elsevier, 2022)
    The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with low treatment efficacy. However, the field is dominated by underpowered studies focusing on major depression not addressing microbiome ...
  • miRNA signatures associated with vulnerability to food addiction in mice and humans
    García Blanco, Alejandra; Domingo Rodriguez, Laura, 1992-; Cabana-Domínguez, Judit; Fernández-Castillo, Noèlia; Pineda-Cirera, Laura; Mayneris Perxachs, Jordi; Burokas, Aurelijus, 1982-; Espinosa-Carrasco, José; Arboleya, Silvia; Latorre, Jessica; Stanton, Catherine; Cormand, Bru; Fernández Real, Jose M.; Martín-García, Elena; Maldonado, Rafael, 1961- (American Society for Clinical Investigation, 2022)
    Food addiction is characterized by a loss of behavioral control over food intake and is associated with obesity and other eating disorders. The mechanisms underlying this behavioral disorder are largely unknown. We aimed ...
  • Moderate-vigorous physical activity across body mass index in females: moderating effect of endocannabinoids and temperament
    Fernández Aranda, Fernando; Sauchelli, Sarah; Pastor, Antonio; González, Marcela L.; Torre Fornell, Rafael de la; Granero, Roser; Jiménez Murcia, Susana; Baños, Rosa M.; Botella, Cristina; Fernández Real, Jose M.; Fernández García, José C.; Frühbeck, Gema; Gómez Ambrosi, Javier; Rodríguez, Roser; Tinahones Madueño, Francisco José; Arcelus, Jon; Fagundo, Ana B.; Agüera, Zaida; Miró, Jordi; Casanueva, Felipe F. (Public Library of Science (PLoS), 2014)
    Background: Endocannabinoids and temperament traits have been linked to both physical activity and body mass index (BMI) however no study has explored how these factors interact in females. The aims of this cross-sectional ...
  • Modulation of Higher-Order Olfaction Components on Executive Functions in Humans.
    Fagundo, Ana B.; Jiménez Murcia, Susana; Giner Bartolomé, Cristina; Anisul Islam, Mohammed; Torre Fornell, Rafael de la; Pastor, Antonio; Casanueva, Felipe F.; Crujeiras, Ana B.; Granero, Roser; Baños, Rosa M.; Botella, Cristina; Fernández Real, Jose M.; Frühbeck, Gema; Gómez Ambrosi, Javier; Menchón, José M.; Tinahones Madueño, Francisco José; Fernández Aranda, Fernando (Public Library of Science, 2015)
    The prefrontal (PFC) and orbitofrontal cortex (OFC) appear to be associated with both executive functions and olfaction. However, there is little data relating olfactory processing and executive functions in humans. The ...
  • Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans
    Fagundo, Ana B.; Torre Fornell, Rafael de la; Jiménez Murcia, Susana; Agüera, Zaida; Pastor, Antonio; Casanueva, Felipe F.; Granero, Roser; Baños, Rosa M.; Botella, Cristina; de Pino Gutiárrez, Amparo; Fernández Real, Jose M.; Fernández García, José C.; Frühbeck, Gema; Gómez Ambrosi, Javier; Menchón, José M.; Moragrega, Inés; Rodríguez, Roser; Tárrega, Salomé; Tinahones Madueño, Francisco José; Fernández Aranda, Fernando (Public Library of Science (PLoS), 2013)
    Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) ...
  • Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
    Arnoriaga Rodríguez, María; Burokas, Aurelijus, 1982-; Ortega Sánchez, Juan Antonio; Maldonado, Rafael, 1961-; Fernández Real, Jose M. (BMJ Publishing Group, 2021)
    Background: Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods: We ...
  • Olfaction in eating disorders and abnormal eating behavior: a systematic review.
    Anisul Islam, Mohammed; Fagundo, Ana B.; Arcelus, Jon; Agüera, Zaida; Jiménez Murcia, Susana; Fernández Real, Jose M.; Tinahones Madueño, Francisco José; Torre Fornell, Rafael de la; Botella, Cristina; Frühbeck, Gema; Casanueva, Felipe F.; Menchón, José M.; Fernández Aranda, Fernando (Frontiers, 2015)
    The study provides a systematic review that explores the current literature on olfactory capacity in abnormal eating behavior. The objective is to present a basis for discussion on whether research in olfaction in eating ...
  • Presence of blastocystis in gut microbiota is associated with cognitive traits and decreased executive function
    Mayneris Perxachs, Jordi; Arnoriaga Rodríguez, María; Garre-Olmo, Josep; Puig, Josep; Ramos, Rafel; Trelis, Maria; Burokas, Aurelijus; Coll, Clàudia; Zapata-Tona, Cristina; Pedraza, Salvador; Pérez Brocal, Vicente; Ramió-Torrentà, Lluís; Ricart, Wifredo; Moya, Andrés; Jové, Mariona; Sol, Joaquim; Portero Otín, Manuel; Pamplona, Reinald; Maldonado, Rafael, 1961-; Fernández Real, Jose M. (Nature Research, 2022)
    Growing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in humans but its potential involvement in human pathophysiology has been poorly ...
  • Recomendaciones para la detección, diagnóstico y seguimiento de los pacientes con enfermedad por hígado graso no alcohólico en atención primaria y hospitalaria
    Caballeria, Llorenc; Augustin, Salvador; Broquetas, Teresa; Morillas, Rosa M.; Vergara, Mercè; Virolés, Silvia; Hernández, Mª Rosario; Serra, Isabel; Goday Arno, Alberto; Vila, Lluis; Siso-Almirall, Antonio; Solans, Rosa; Fernández Real, Jose M.; Carrión Rodríguez, José Antonio; Graupera, Isabel; Ginès, Pere (Elsevier, 2019)
    La enfermedad por hígado graso no alcohólico (EHGNA) es una de las enfermedades hepáticas crónicas más frecuentes, con una prevalencia del 20-30% en la población general y del 60-80% en poblaciones de riesgo. En un porcentaje ...