Browsing by Author "Fernández Fuentes, Narcís"

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  • Fernández Fuentes, Narcís; Molina, Ruben; Oliva Miguel, Baldomero (MDPI, 2021)
    The angiotensin-converting enzyme 2 (ACE2) is the receptor used by SARS-CoV and SARS-CoV-2 coronaviruses to attach to cells via the receptor-binding domain (RBD) of their viral spike protein. Since the start of the COVID-19 ...
  • Aguirre Plans, Joaquim, 1993-; Piñero González, Janet, 1977-; Souza, Terezinha; Callegaro, Giulia; Kunnen, Steven J.; Sanz, Ferran; Fernández Fuentes, Narcís; Furlong, Laura I., 1971-; Guney, Emre; Oliva Miguel, Baldomero (BioMed Central, 2021)
    Background: Drug-induced liver injury (DILI) is an adverse reaction caused by the intake of drugs of common use that produces liver damage. The impact of DILI is estimated to affect around 20 in 100,000 inhabitants worldwide ...
  • Bonet Martínez, Jaume, 1982-; Planas Iglesias, Joan, 1980-; García-García, Javier, 1982-; Marín López, Manuel Alejandro, 1987-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2014)
    The function of a protein is determined by its three-dimensional structure, which is formed by regular (i.e. β-strands and α-helices) and non-periodic structural units such as loops. Compared to regular structural elements, ...
  • Segura, Joan; Oliva Miguel, Baldomero; Fernández Fuentes, Narcís (Oxford University Press, 2012)
    The regions of the polypeptide chain immediately preceding or following an α-helix are known as Nt- and Ct cappings, respectively. Cappings play a central role stabilizing α-helices due to lack of intrahelical hydrogen ...
  • Badia Villanueva, Miriam; Defaus, Sira; Foj, Ruben; Andreu Martínez, David; Oliva Miguel, Baldomero; Sierra, Angels; Fernández Fuentes, Narcís (MDPI, 2021)
    The tumour necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumour necrosis factor ligand family and has been shown to be overexpressed in tumoral cells together with the fibroblast growth ...
  • Rubio Pérez, Carlota, 1990-; Güney, Emre, 1983-; Aguilar, Daniel; Piñero González, Janet, 1977-; García-García, Javier, 1982-; Iadarola, Barbara; Sanz, Ferran; Fernández Fuentes, Narcís; Furlong, Laura I., 1971-; Oliva Miguel, Baldomero (Nature Publishing Group, 2017)
    Understanding relationships between diseases, such as comorbidities, has important socio-economic implications, ranging from clinical study design to health care planning. Most studies characterize disease comorbidity using ...
  • Aguirre Plans, Joaquim, 1993-; Piñero González, Janet, 1977-; Sanz, Ferran; Furlong, Laura I., 1971-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero; Guney, Emre (Elsevier, 2019)
    The genetic basis of complex diseases involves alterations on multiple genes. Unraveling the interplay between these genetic factors is key to the discovery of new biomarkers and treatments. In 2014, we introduced GUILDify, ...
  • Artigas, Laura; Coma Camprodón, Mireia; Matos Filipe, Pedro; Aguirre Plans, Joaquim, 1993-; Farrés, Judith; Valls, Raquel; Fernández Fuentes, Narcís; Haba Rodríguez, Juan de la; Olvera, Alex; Barbera, Jose; Morales, Rafael; Oliva Miguel, Baldomero; Mas, José Manuel (Public Library of Science (PLoS), 2020)
    From January 2020, COVID-19 is spreading around the world producing serious respiratory symptoms in infected patients that in some cases can be complicated by the severe acute respiratory syndrome, sepsis and septic shock, ...
  • Jorba, Guillem; Aguirre Plans, Joaquim, 1993-; Junet, Valentin; Segú Vergés, Cristina; Ruiz, José Luis; Pujol, Albert; Fernández Fuentes, Narcís; Mas, José Manuel; Oliva Miguel, Baldomero (Public Library of Science (PLoS), 2020)
    Unveiling the mechanism of action of a drug is key to understand the benefits and adverse reactions of a medication in an organism. However, in complex diseases such as heart diseases there is not a unique mechanism of ...
  • Marín López, Manuel Alejandro, 1987-; Planas Iglesias, Joan, 1980-; Aguirre Plans, Joaquim, 1993-; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2018)
    MOTIVATION: The characterization of the protein-protein association mechanisms is crucial to understanding how biological processes occur. It has been previously shown that the early formation of non-specific encounters ...
  • Meseguer, Alberto; Årman, Filip; Fornés Crespo, Oriol, 1983-; Molina Fernández, Rubén; Bonet Martínez, Jaume, 1982-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2020)
    Cis2-His2 zinc finger (C2H2-ZF) proteins are the largest family of transcription factors in human and higher metazoans. To date, the DNA-binding preferences of many members of this family remain unknown. We have developed ...
  • Anton, Bernat; Besalú, Mireia; Fornés Crespo, Oriol, 1983-; Bonet Martínez, Jaume, 1982-; Molina, Alexis; Molina Fernández, Rubén; Cuevas, Gemma de las; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2021)
    Direct-coupling analysis (DCA) for studying the coevolution of residues in proteins has been widely used to predict the three-dimensional structure of a protein from its sequence. We present RADI/raDIMod, a variation of ...
  • Aguirre Plans, Joaquim, 1993-; Meseguer, Alberto; Molina Fernández, Rubén; Marín López, Manuel Alejandro, 1987-; Jumde, Gaurav; Casanova, Kevin; Bonet Martínez, Jaume, 1982-; Fornés Crespo, Oriol, 1983-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (BioMed Central, 2021)
    Background: Statistical potentials, also named knowledge-based potentials, are scoring functions derived from empirical data that can be used to evaluate the quality of protein folds and protein-protein interaction (PPI) ...
  • Segura, Joan; Marín López, Manuel Alejandro, 1987-; Jones, Pamela F.; Oliva Miguel, Baldomero; Fernández Fuentes, Narcís (Public Library of Science, 2015)
    The experimental determination of the structure of protein complexes cannot keep pace with the generation of interactomic data, hence resulting in an ever-expanding gap. As the structural details of protein complexes are ...