Browsing by Author "Fernàndez Busquets, Xavier"

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  • Characterization of domiphen bromide as a new fast-acting antiplasmodial agent inhibiting the apicoplastidic methyl erythritol phosphate pathway
    Biosca, Arnau; Ramírez, Miriam; Gomez-Gomez, Àlex; Lafuente, Aritz; Iglesias, Valentin; Pozo Mendoza, Óscar J., 1975-; Imperial, Santiago; Fernàndez Busquets, Xavier (MDPI, 2022)
    The evolution of resistance by the malaria parasite to artemisinin, the key component of the combination therapy strategies that are at the core of current antimalarial treatments, calls for the urgent identification of ...
  • Coupling the antimalarial cell penetrating peptide TP10 to classical antimalarial drugs primaquine and chloroquine produces strongly hemolytic conjugates
    Aguiar, Luísa; Biosca, Arnau; Lantero, Elena; Gut, Jiri; Vale, Nuno; Rosenthal, Philip J.; Nogueira, Fátima; Andreu Martínez, David; Fernàndez Busquets, Xavier; Gomes, Paula (MDPI, 2019)
    Recently, we disclosed primaquine cell penetrating peptide conjugates that were more potent than parent primaquine against liver stage Plasmodium parasites and non-toxic to hepatocytes. The same strategy was now applied ...
  • Differential regulation of insulin signalling by monomeric and oligomeric amyloid beta-peptide
    Molina Fernández, Rubén; Picón-Pagès, Pol; Barranco Almohalla, Alejandro; Crepin, Giulia; Herrera-Fernández, Víctor; García-Elías, Anna; Fanlo-Ucar, Hugo; Fernàndez Busquets, Xavier; García Ojalvo, Jordi; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Oxford University Press, 2022)
    Alzheimer's disease and Type 2 diabetes are pathological processes associated to ageing. Moreover, there are evidences supporting a mechanistic link between Alzheimer's disease and insulin resistance (one of the first ...
  • Discovering putative prion-like proteins in plasmodium falciparum: a computational and experimental analysis
    Pallarès, Irantzu; de Groot, Natalia S.; Iglesias, Valentin; Sant'Anna, Ricardo; Biosca, Arnau; Fernàndez Busquets, Xavier; Ventura, Salvador (Frontiers, 2018)
    Prions are a singular subset of proteins able to switch between a soluble conformation and a self-perpetuating amyloid state. Traditionally associated with neurodegenerative diseases, increasing evidence indicates that ...
  • Human albumin impairs amyloid β-peptide fibrillation through its C-terminus: from docking modeling to protection against neurotoxicity in alzheimer's disease
    Picón-Pagès, Pol; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Garcia-Buendia, Joan; Gutierrez, Daniela; Valle, Javier; Gómez-Casuso, Carmen E.S.; Sidelkivska, Valeriya; Alvarez, Alejandra; Perálvarez Marín, Alex; Suades, Albert; Fernàndez Busquets, Xavier; Andreu Martínez, David; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Elsevier, 2019)
    Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate ...
  • Posttranslational nitro-glycative modifications of albumin in Alzheimer's disease: implications in cytotoxicity and amyloid-β peptide aggregation
    Ramos Fernández, Eva, 1984-; Tajes Orduña, Marta; Palomer, Ernest; Ill-Raga, Gerard, 1982-; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Roman Degano, Irene; Eraso Pichot, Abel; Alcolea, Daniel; Fortea, Juan; Núñez, Laura; Páez, Antonio; Alameda Quitllet, Francisco; Fernàndez Busquets, Xavier; Lleó, Alberto; Elosua Llanos, Roberto; Boada, Mercè; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (IOS Press, 2014)
    Glycation and nitrotyrosination are pathological posttranslational modifications that make proteins prone to losing their physiological properties. Since both modifications are increased in Alzheimer's disease (AD) due to ...
  • The antigen-binding fragment of human gamma immunoglobulin prevents amyloid β-peptide folding into β-sheet to form oligomers
    Valls Comamala, Victòria, 1987-; Guivernau Almazán, Biuse, 1988-; Bonet Martínez, Jaume, 1982-; Puig, Marta; Perálvarez Marín, Alex; Palomer, Ernest; Fernàndez Busquets, Xavier; Altafaj, Xavier; Tajes Orduña, Marta; Puig Pijoan, Albert; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Impact Journals, 2017)
    The amyloid beta-peptide (Aβ) plays a leading role in Alzheimer's disease (AD) physiopathology. Even though monomeric forms of Aβ are harmless to cells, Aβ can aggregate into β-sheet oligomers and fibrils, which are both ...
  • The blood-brain barrier: structure, function and therapeutic approaches to cross it
    Tajes Orduña, Marta; Ramos Fernández, Eva, 1984-; Weng-Jiang, Xian; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Eraso Pichot, Abel; Salvador, Bertrán; Fernàndez Busquets, Xavier; Roquer, Jaume; Muñoz López, Francisco José, 1964- (Taylor & Francis (Routledge), 2014)
    The blood-brain barrier (BBB) is constituted by a specialized vascular endothelium that interacts directly with astrocytes, neurons and pericytes. It protects the brain from the molecules of the systemic circulation but ...