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Listar por autoría "Esteve-Codina, Anna"

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A comparison of RNA-Seq results from paired formalin-fixed paraffin-embedded and fresh-frozen glioblastoma tissue samples

Esteve-Codina, Anna; Arpí Llucià, Oriol; Martínez-García, Maria; Pineda, Estela; Mallo, Mar; Gut, Marta; Carrato, Cristina; Rovira Guerín, Ana; Lopez, Raquel; Tortosa, Avelina; Dabad, Marc; del Barco, Sonia; Heath, Simon; Bagué, Silvia; Ribalta, Teresa; Alameda Quitllet, Francisco; de la Iglesia, Nuria; Balaña, Carmen; GLIOCAT Group (Public Library of Science (PLoS), 2017)

The molecular classification of glioblastoma (GBM) based on gene expression might better explain outcome and response to treatment than clinical factors. Whole transcriptome sequencing using next-generation sequencing ...
A human in vitro neuronal model for studying homeostatic plasticity at the network level

Yuan, Xiuming; Puvogel, Sofía; van Rhijn, Jon-Ruben; Ciptasari, Ummi; Esteve-Codina, Anna; Meijer, Mandy; Rouschop, Simon; van Hugte, Eline J. H.; Oudakker, Astrid; Schoenmaker, Chantal; Frega, Monica; Schubert, Dirk; Franke, Barbara; Nadif Kasri, Nael (Elsevier, 2023)

Mechanisms that underlie homeostatic plasticity have been extensively investigated at single-cell levels in animal models, but are less well understood at the network level. Here, we used microelectrode arrays to characterize ...
A Stenotrophomonas maltophilia TetR-like transcriptional regulator involved in fatty acid metabolism is controlled by quorum sensing signals

Coves, Xavier; Bravo, Marc; Huedo, Pol; Conchillo-Solé, Òscar; Gómez, Andromeda-Celeste; Esteve-Codina, Anna; Dabad, Marc; Gut, Marta; Daura, Xavier; Yero, Daniel; Gibert, Isidre (American Society for Microbiology, 2023)

Stenotrophomonas maltophilia is an environmental bacterium as well as an emerging opportunistic multidrug-resistant pathogen. They use the endogenous diffusible signal factor (DSF) quorum sensing (QS) system to coordinate ...
Alteration in the Culex pipiens transcriptome reveals diverse mechanisms of the mosquito immune system implicated upon Rift Valley fever phlebovirus exposure

Núñez, Ana I.; Esteve-Codina, Anna; Gómez-Garrido, Jèssica; Brustolin, Marco; Talavera, Sandra; Berdugo, Miguel; Dabad, Marc; Alioto, Tyler; Bensaid, Albert; Busquets, Núria (Public Library of Science (PLoS), 2020)

Rift Valley fever phlebovirus (RVFV) causes an emerging zoonotic disease and is mainly transmitted by Culex and Aedes mosquitoes. While Aedes aegypti-dengue virus (DENV) is the most studied model, less is known about the ...
Analysis of Vibrio harveyi adaptation in sea water microcosms at elevated temperature provides insights into the putative mechanisms of its persistence and spread in the time of global warming

Montánchez, Itxaso; Ogayar, Elixabet; Hernández Plágaro, Ander; Esteve-Codina, Anna; Gómez-Garrido, Jèssica; Orruño, Maite; Arana, Inés; Kaberdin, Vladimir R. (Nature Research, 2019)

Discovering the means to control the increasing dissemination of pathogenic vibrios driven by recent climate change is challenged by the limited knowledge of the mechanisms in charge of Vibrio spp. persistence and spread ...
Blastomeres of 8-cell mouse embryos differ in their ability to generate embryonic stem cells and produce lines with different transcriptional signatures

Alonso-Alonso, Sandra; Esteve-Codina, Anna; Martín-Mur, Beatriz; Álvarez-González, Lucía; Ruiz Herrera, Aurora; Santaló, Josep; Ibáñez, Elena (Frontiers, 2023)

Embryonic stem cell (ESC) derivation from single blastomeres of 8-cell mouse embryos results in lower derivation rates than that from whole blastocysts, raising a biological question about the developmental potential of ...
Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma

George, Leena; Esteve-Codina, Anna; Soler Artigas, María; Thun, Gian Andri; Heath, Simon; Gut, Ivo Glynne; Brightling, Christopher E. (Wiley, 2020)

BACKGROUND: Whether the clinical or pathophysiologic significance of the "treatable trait" high blood eosinophil count in COPD is the same as for asthma remains controversial. We sought to determine the relationship between ...
Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species

Anastasiadi, Dafni, 1986-; Esteve-Codina, Anna; Piferrer, Francesc (BioMed Central, 2018)

Background: DNA methylation is one of the main epigenetic mechanisms for the regulation of gene expression in eukaryotes. In the standard model, methylation in gene promoters has received the most attention since it is ...
CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst

Zagmutt, Sebastián; Martin, Beatriz; Esteve-Codina, Anna; Serra, Dolors (BioMed Central, 2023)

Background: Fatty acid metabolism in the hypothalamus has an important role in food intake, but its specific role in AgRP neurons is poorly understood. Here, we examined whether carnitinea palmitoyltransferase 1A (CPT1A), ...
CRISPR editing of sftb-1/SF3B1 in Caenorhabditis elegans allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicing

Serrat Farran, Xènia, 1993-; Kukhtar, Dmytro; Cornes Maragliano, Eric, 1987-; Esteve-Codina, Anna; Benlloch, Helena; Cecere, Germano; Cerón Madrigal, Julián (Public Library of Science (PLoS), 2019)

SF3B1 is the most frequently mutated splicing factor in cancer. Mutations in SF3B1 likely confer clonal advantages to cancer cells but they may also confer vulnerabilities that can be therapeutically targeted. SF3B1 cancer ...
Cross-protection against African swine fever virus upon intranasal vaccination is associated with an adaptive-innate immune crosstalk

Bosch-Camós, Laia; Alonso, Uxía; Esteve-Codina, Anna; Chang, Chia-Yu; Martín-Mur, Beatriz; Accensi, Francesc; Muñoz, Marta; Navas, María J.; Dabad, Marc; Vidal, Enric; Pina-Pedrero, Sonia; Pleguezuelos, Patricia; Caratù, Ginevra; Salas, María L.; Liu, Lihong; Bataklieva, Stanimira; Gavrilov, Boris; Rodríguez, Fernando; Argilaguet Marqués, Jordi, 1977- (Public Library of Science (PLoS), 2022)

African swine fever virus (ASFV) is causing a worldwide pandemic affecting the porcine industry and leading to important global economic consequences. The virus causes a highly lethal hemorrhagic disease in wild boars and ...
De Novo assembly and annotation of the larval transcriptome of two spadefoot toads widely divergent in developmental rate

Liedtke, H. Christoph; Gómez Garrido, Jèssica; Esteve-Codina, Anna; Gut, Marta; Alioto, Tyler; Gomez-Mestre, Ivan (Genetics Society of America, 2019)

Amphibians are highly vulnerable and diverse vertebrates for which we still have modest genomic resources. Amphibian larvae are key components of continental wetlands, where they have strong influences on energy fluxes, ...
De novo transcriptome sequencing and gene co-expression reveal a genomic basis for drought sensitivity and evidence of a rapid local adaptation on Atlas cedar (Cedrus atlantica)

Cobo-Simón, Irene; Gómez-Garrido, Jèssica; Esteve-Codina, Anna; Dabad, Marc; Alioto, Tyler; Maloof, Julin N.; Méndez-Cea, Belén; Seco, José Ignacio; Linares, Juan Carlos; Gallego, Francisco Javier (Frontiers, 2023)

Introduction: Understanding the adaptive capacity to current climate change of drought-sensitive tree species is mandatory, given their limited prospect of migration and adaptation as long-lived, sessile organisms. Knowledge ...
Decreased expression of synaptic genes in the vestibular ganglion of rodents following subchronic ototoxic stress

Greguske, Erin A.; Maroto, Alberto F.; Borrajo, Mireia; Palou, Aïda; Gut, Marta; Esteve-Codina, Anna; Barrallo-Gimeno, Alejandro; Llorens, Jordi (Elsevier, 2023)

The vestibular ganglion contains primary sensory neurons that are postsynaptic to the transducing hair cells (HC) and project to the central nervous system. Understanding the response of these neurons to HC stress or loss ...
Deep analysis of acquired resistance to FGFR1 inhibitor identifies MET and AKT activation and an expansion of AKT1 mutant cells

Giménez Xavier, Pol; Pros, Eva; Aza, Ana; Moran, Sebastian; Tonda, Raúl; Esteve-Codina, Anna; Dabad, Marc; Sánchez Céspedes, Montse (Impact Journals, 2018)

The development of acquired resistance (AR) to tyrosine kinase inhibitors (TKIs) of FGFR1 activation is currently not well understood. To gain a deeper insight into this matter in lung cancer, we used the FGFR1-amplified ...
Developmental RNA-Seq transcriptomics of haploid germ cells and spermatozoa uncovers novel pathways associated with teleost spermiogenesis

Castro-Arnau, Júlia; Chauvigné, François; Gómez-Garrido, Jèssica; Esteve-Codina, Anna; Dabad, Marc; Alioto, Tyler; Finn, Roderick Nigel; Cerdà, Joan (Nature Research, 2022)

In non-mammalian vertebrates, the molecular mechanisms involved in the transformation of haploid germ cells (HGCs) into spermatozoa (spermiogenesis) are largely unknown. Here, we investigated this process in the marine ...
Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation

Casella, Valentina, 1991-; Domenjó Vila, Eva, 1993-; Esteve-Codina, Anna; Pedragosa Marín, Mireia, 1988-; Cebollada Rica, Paula; Vidal, Enric; Rubia, Ivan de la; López Rodríguez, M. Cristina; Bocharov, Gennady A.; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Nature Research, 2023)

Acute infection and chronic infection are the two most common fates of pathogenic virus infections. While several factors that contribute to these fates are described, the critical control points and the mechanisms that ...
Dual role of integrin Alpha-6 in glioblastoma: supporting stemness in proneural stem-like cells while inducing radioresistance in mesenchymal stem-like cells

Stanzani, Elisabetta; Pedrosa, Leire; Bourmeau, Guillaume; Anezo, Oceane; Noguera-Castells, Aleix; Esteve-Codina, Anna; Passoni, Lorena; Matteoli, Michela; de la Iglesia, Nuria; Seano, Giorgio; Martínez-Soler, Fina; Tortosa, Avelina (MDPI, 2021)

Therapeutic resistance after multimodal therapy is the most relevant cause of glioblastoma (GBM) recurrence. Extensive cellular heterogeneity, mainly driven by the presence of GBM stem-like cells (GSCs), strongly correlates ...
Endothelial deletion of Wt1 disrupts coronary angiogenesis and myocardium development

Ramiro-Pareta, Marina; Müller-Sánchez, Claudia; Portella-Fortuny, Rosa; Soler-Botija, Carolina; Torres-Cano, Alejo; Esteve-Codina, Anna; Bayés-Genís, Antoni; Reina, Manuel; Soriano, Francesc X.; Montanez, Eloi; Martínez-Estrada, Ofelia M. (Company of Biologists, 2023)

Wt1 encodes a zinc finger protein that is crucial for epicardium development. Although WT1 is also expressed in coronary endothelial cells (ECs), the abnormal heart development observed in Wt1 knockout mice is mainly ...
Enhanced susceptibility to tomato chlorosis virus (ToCV) in Hsp90- and Sgt1-silenced pPlants: insights from gene expression dynamics

Ontiveros, Irene; Fernández-Pozo, Noé; Esteve-Codina, Anna; López-Moya, Juan José; Díaz Pendón, Juan Antonio (MDPI, 2023)

The emerging whitefly-transmitted crinivirus tomato chlorosis virus (ToCV) causes substantial economic losses by inducing yellow leaf disorder in tomato crops. This study explores potential resistance mechanisms by examining ...