Browsing by Author "Espinosa Blay, Lluís"

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  • A novel role of MNT as a negative regulator of REL and the NF-κB pathway
    Liaño-Pons, Judit; Lafita-Navarro, M. Carmen; García-Gaipo, Lorena; Colomer Montañà, Carlota, 1990-; Rodríguez, Javier; von Kriegsheim, Alex; Hurlin, Peter J.; Ourique, Fabiana; Delgado, M. Dolores; Bigas Salvans, Anna; Espinosa Blay, Lluís; León, Javier (Nature Research, 2021)
    MNT, a transcription factor of the MXD family, is an important modulator of the oncoprotein MYC. Both MNT and MYC are basic-helix-loop-helix proteins that heterodimerize with MAX in a mutually exclusive manner, and bind ...
  • A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia
    Robles-Valero, Javier; Lorenzo-Martín, L. Francisco; Menacho Márquez, Mauricio; Fernández-Pisonero, Isabel; Abad, Antonio; Camós, Mireia; Toribio, María Luisa; Espinosa Blay, Lluís; Bigas Salvans, Anna; Bustelo, Xose R. (Elsevier, 2017)
    Rho guanine exchange factors (GEFs), the enzymes that stimulate Rho GTPases, are deemed as potential therapeutic targets owing to their protumorigenic functions. However, the understanding of the spectrum of their ...
  • A truncated form of IKKα is responsible for specific nuclear IKK activity in colorectal cancer
    Margalef González, Pol, 1985-; Fernández Majada, Vanessa; Villanueva, Alberto; Garcia Carbonell, Ricard; Iglesias Coma, Mar; López Muñoz, Laura; Martínez Iniesta, María; Villà i Freixa, Jordi; Mulero, María Carmen; Andreu García, Montserrat; Torres, Ferran; Mayo, Marty W.; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2012)
    Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked to cancer progression and metastasis. However, the mechanistic connection between tumorigenesis and IKKα activity remains ...
  • Accumulation of paneth cells in early colorectal adenomas is associated with beta-catenin signaling and poor patient prognosis
    López Arribillaga, Erika, 1986-; Yan, Bing; Lobo-Jarne, Teresa; Guillén, Yolanda; Menéndez, Silvia; Andreu García, Montserrat; Bigas Salvans, Anna; Iglesias Coma, Mar; Espinosa Blay, Lluís (MDPI, 2021)
    Background: previous studies in mice indicated that Paneth cells and c-Kit-positive goblet cells represent the stem cell niche of the small intestine and colon, respectively, partly by supporting Wnt and Notch activation. ...
  • Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development
    Brena, David; Bertran, Joan; Porta de la Riva, Montserrat; Guillén, Yolanda; Cornes Maragliano, Eric, 1987-; Kukhtar, Dmytro; Campos-Vicens, Lluís; Fernández, Lierni; Pecharroman, Irene; García-López, Albert; Islam, Abul, 1978-; Marruecos, Laura; Bigas Salvans, Anna; Cerón Madrigal, Julián; Espinosa Blay, Lluís (Nature Research, 2020)
    Mammalian IκB proteins (IκBs) exert their main function as negative regulators of NF-κB, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for IκBs has been shown to affect ...
  • Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch
    López Arribillaga, Erika, 1986-; Rodilla, Verónica; Pellegrinet, Luca; Guiu Sagarra, Jordi, 1983-; Iglesias Coma, Mar; Roman, Angel Carlos; Gutarra, Susana; González, Susana; Muñoz Cánoves, Pura, 1962-; Fernández-Salguero, Pedro; Radtke, Freddy; Bigas Salvans, Anna; Espinosa Blay, Lluís (Company of Biologists, 2015)
    Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation ...
  • BRAF-induced tumorigenesis is IKKα-dependent but NF-κB-independent
    Margalef González, Pol, 1985-; Colomer Montañà, Carlota, 1990-; Villanueva, Alberto; Montagut Viladot, Clara; Iglesias Coma, Mar; Bellosillo Paricio, Beatriz; Salazar, Ramón; Martínez Iniesta, María; Bigas Salvans, Anna; Espinosa Blay, Lluís (American Association for the Advancement of Science, 2015)
    KRAS mutations contribute to cell proliferation and survival in numerous cancers, including colorectal cancers (CRC). One pathway through which mutant KRAS acts is an inflammatory pathway that involves the kinase IKK and ...
  • Chromatin-bound IκB-alpha regulates a subset of polycomb target genes in differentiation and cancer
    Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika, 1986-; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2013)
    IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of ...
  • Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance
    Gallardo Hernández, Fernando; Padrón, Andreina; Garcia Carbonell, Ricard; Rius, Cristina; González-Pérez, Abel; Arumí, Montserrat; Iglesias Coma, Mar; Nonell Mazelon, Lara, 1972-; Bellosillo Paricio, Beatriz; Segura Tigell, Sonia; Pujol Vallverdú, Ramon Maria; López Bigas, Núria; Bertran, Joan; Bigas Salvans, Anna; Espinosa Blay, Lluís (Impact Journal, 2015)
    Invasive malignant melanoma (MM) is an aggressive tumor with no curative therapy available in advanced stages. Nuclear corepressor (NCoR) is an essential regulator of gene transcription, and its function has been found ...
  • Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-κB target genes in human breast cancer
    Dalmases Massegú, Alba, 1982-; González González, Irene; Menendez Romero, Silvia; Arpí Llucià, Oriol; Corominas Torres, Josep Maria; Servitja Tormo, Sonia; Tusquets Trias de Bes, Ignacio; Chamizo, Cristina; Rincón, Raúl; Espinosa Blay, Lluís; Bigas Salvans, Anna; Eroles, Pilar; Furriol, Jessica; Lluch, Ana; Rovira Guerín, Ana; Albanell Mestres, Joan; Rojo, Federico (Impact Journals, 2014)
    NF-кB has been linked to doxorubicin resistance in breast cancer patients. NF-кB nuclear translocation and DNA binding in doxorubicin treated-breast cancer cells have been extensively examined; however its functional ...
  • Dynamic chromatin association of IκBα is regulated by acetylation and cleavage of histone H4
    Marruecos, Laura; Bertran, Joan; Álvarez-Villanueva, Daniel; Mulero, María Carmen; Guillén, Yolanda; Palma, Luis G.; Floor, Martin; Vert, Anna; Arce-Gallego, Sara; Pecharroman, Irene; Batlle Masó, Laura, 1993-; Villà i Freixa, Jordi; Ghosh, Gourisankar; Bigas Salvans, Anna; Espinosa Blay, Lluís (Wiley, 2021)
    IκBs exert principal functions as cytoplasmic inhibitors of NF-kB transcription factors. Additional roles for IκB homologues have been described, including chromatin association and transcriptional regulation. Phosphorylated ...
  • Endosomal acidification inhibitors for the treatment of BRAF mutant tumors.
    Espinosa Blay, Lluís (Taylor & Francis, 2016)
    Mutations in KRAS and BRAF genes are commonly found in several types of cancer associated with poor prognosis and therapy resistance. We have identified phosphorylated p45-IKKα as an essential mediator of BRAF-induced ...
  • Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions
    Bueno, Clara; Calero-Nieto, Fernando J.; Wang, Xiaonan; Valdés-Mas, Rafael; Gutiérrez-Agüera, Francisco; Roca-Ho, Heleia; Ayllon, Verónica; Real, Pedro J.; Arambilet, David; Espinosa Blay, Lluís; Torres-Ruiz, Raul; Agraz-Doblas, Antonio; Varela, Ignacio; de Boer, Jasper; Bigas Salvans, Anna; Gottgens, Bertie; Marschalek, Rolf; Menéndez, Pablo (Ferrata Storti Foundation, 2019)
    The t(4;11)(q21;q23) translocation is associated with high-risk infant pro-B-cell acute lymphoblastic leukemia and arises prenatally during embryonic/fetal hematopoiesis. The developmental/pathogenic contribution of the ...
  • Epigenetic silencing of tumor suppressor miR-124 directly supports STAT3 activation in cutaneous T-Cell lymphoma
    García-Colmenero, Lidia; González Miranda, Jessica; Sandoval, Juan; Guillén, Yolanda; Diaz-Lagares, Angel; Andrades, Evelyn; Iglesias, Arnau; Nonell Mazelon, Lara, 1972-; Pujol Vallverdú, Ramon Maria; Bigas Salvans, Anna; Espinosa Blay, Lluís; Gallardo Hernández, Fernando (MDPI, 2020)
    Increasing evidence supports a potential role for STAT3 as a tumor driver in cutaneous T-cell lymphomas (CTCL). The mechanisms leading to STAT3 activation are not fully understood; however, we recently found that miR-124, ...
  • Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas
    Bredel, Markus; Espinosa Blay, Lluís; Solé, Laura; Chakravarti, Arnab (Elsevier, 2023)
    Genetic alterations help predict the clinical behavior of diffuse gliomas, but some variability remains uncorrelated. Here, we demonstrate that haploinsufficient deletions of chromatin-bound tumor suppressor NFKB inhibitor ...
  • Identification and characterization of an oncogenic form of IKKα in colorectal cancer
    Margalef González, Pol, 1985- (Universitat Pompeu Fabra, 2015-07-15)
    L’IKKα nuclear regula la transcripció gènica i ha estat relacionada amb la progressió del càncer i la metàstasis, tot i que la connexió mecanística no s’entén massa bé. Hem observat que les ...
  • Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence
    Islam, Abul, 1978-; Guiu Sagarra, Jordi, 1983-; Bergen, Dylan J.M.; de Pater, Emma; Ayllon, Verónica; Gama-Norton, Leonor; Ruiz Herguido, Cristina; González, Jessica; López Bigas, Núria; Menéndez, Pablo; Dzierzak, Elaine; Espinosa Blay, Lluís; Bigas Salvans, Anna (Rockefeller University Press, 2014)
    Hematopoietic stem cell (HSC) specification occurs in the embryonic aorta and requires Notch activation; however, most of the Notch-regulated elements controlling de novo HSC generation are still unknown. Here, we identify ...
  • IKKα is required in the intestinal epithelial cells for tumour stemness
    Colomer Montañà, Carlota, 1990-; Margalef González, Pol, 1985-; González, Jessica; Vert, Anna; Bigas Salvans, Anna; Espinosa Blay, Lluís (Nature Publishing Group, 2018)
    BACKGROUND: Colorectal cancer is a common cause of death in developed countries. Progression from adenoma to invasive carcinoma requires accumulation of mutations starting with the Adenomatous Polyposis Coli (Apc) gene. ...
  • IKKα kinase regulates the DNA damage response and drives chemo-resistance in cancer
    Colomer Montañà, Carlota, 1990-; Margalef González, Pol, 1985-; Villanueva, Alberto; Vert, Anna; Pecharroman, Irene; Solé, Laura; González-Farré, Mónica; Alonso, Josune; Montagut Viladot, Clara; Martínez Iniesta, María; Bertran, Joan; Borràs, Eva; Iglesias, Mar; Sabidó Aguadé, Eduard, 1981-; Bigas Salvans, Anna; Boulton, Simon J.; Espinosa Blay, Lluís (Elsevier, 2019)
    Phosphorylated IKKalpha(p45) is a nuclear active form of the IKKalpha kinase that is induced by the MAP kinases BRAF and TAK1 and promotes tumor growth independent of canonical NF-¿B signaling. Insights into the sources ...
  • Inhibition of specific NF-KB activity contributes to the tumor suppressor function of 14-3-3omega in breast cancer
    Inglés Esteve, Julia; Morales, Mònica; Dalmases Massegú, Alba, 1982-; Garcia Carbonell, Ricard; Jené i Sanz, Alba, 1984-; López Bigas, Núria; Iglesias Coma, Mar; Ruiz Herguido, Cristina; Rovira Guerín, Ana; Rojo, Federico; Albanell Mestres, Joan; Gomis, Roger R.; Bigas Salvans, Anna; Espinosa Blay, Lluís (Public Library of Science (PLoS), 2012)
    14-3-3σ is frequently lost in human breast cancers by genetic deletion or promoter methylation. We have now investigated the involvement of 14-3-3σ in the termination of NF-κB signal in mammary cells and its putative role ...

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