Browsing by Author "Espinar, Lorena"

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  • Pokusaeva, Victoria O.; Usmanova, Dinara R.; Putintseva, Ekaterina V.; Espinar, Lorena; Sarkisyan, Karen S.; Mishin, Alexander S.; Bogatyreva, Natalya S.; Ivankov, Dmitry N.; Akopyan, Arseniy V.; Avvakumov, Sergey Ya; Povolotskaya, Inna, 1986-; Filion, Guillaume; Carey, Lucas, 1980-; Kondrashov, Fyodor A., 1979- (Public Library of Science (PLoS), 2019)
    Characterizing the fitness landscape, a representation of fitness for a large set of genotypes, is key to understanding how genetic information is interpreted to create functional organisms. Here we determined the ...
  • Pascual-Reguant, Laura; Datta, Debayan; Cianferoni, Damiano; Kourtis, Savvas; Gañez-Zapater, Antoni; Cannatá, Chiara; Espinar, Lorena; García López, Laura; Musa-Afaneh, Sara; Guirola, Maria; Gkanogiannis, Anestis; Miró Canturri, Andrea; Arribas, Joaquín; Serrano Pubull, Luis, 1982-; Sdelci, Sara (EMBO Press, 2023)
    Triple-negative breast cancer (TNBC) often develops resistance to single-agent treatment, which can be circumvented using targeted combinatorial approaches. Here, we demonstrate that the simultaneous inhibition of LOXL2 ...
  • Espinar, Lorena; Schikora Tamarit, Miquel Àngel; Domingo Espinós, Júlia, 1991-; Carey, Lucas, 1980- (Cold Spring Harbor Laboratory Press (CSHL Press), 2018)
    Information that regulates gene expression is encoded throughout each gene but if different regulatory regions can be understood in isolation, or if they interact, is unknown. Here we measure mRNA levels for 10,000 open ...
  • Kuchina, Anna; Espinar, Lorena; García Ojalvo, Jordi; Süel, Gürol M. (Public Library of Science (PLoS), 2011)
    Cells must make reliable decisions under fluctuating extracellular conditions, but also be flexible enough to adapt to such changes. How cells reconcile these seemingly contradictory requirements through the dynamics of ...
  • Dijk, David van; Dhar, Riddhiman; Missarova, Alsu, 1990-; Espinar, Lorena; Blevins, William Robert, 1987-; Lehner, Ben, 1978-; Carey, Lucas, 1980- (Nature Publishing Group, 2015)
    Isogenic cells show a large degree of variability in growth rate, even when cultured in the same environment. Such cell-to-cell variability in growth can alter sensitivity to antibiotics, chemotherapy and environmental ...
  • Pokusaeva, Victoria O.; Rosado Diez, Aránzuru; Espinar, Lorena; Torelló Pérez, Albert; Filion, Guillaume (BioMed Central, 2022)
    Background: Biases of DNA repair can shape the nucleotide landscape of genomes at evolutionary timescales. The molecular mechanisms of those biases are still poorly understood because it is difficult to isolate the ...
  • Kuchina, Anna; Espinar, Lorena; Cagatay, Tolga; Balbin, Alejandro O.; Zhang, Fang; Alvarado, Alma; García Ojalvo, Jordi; Süel, Gürol M. (Nature Publishing Group, 2011)
    Multipotent differentiation, where cells adopt one of several possible fates, occurs in diverse systems ranging from bacteria to mammals. This decision-making process is driven by multiple differentiation programs that ...
  • Blevins, William Robert, 1987-; Ruiz Orera, Jorge, 1988-; Messeguer, Xavier; Blasco Moreno, Bernat, 1986-; Villanueva Cañas, José Luis, 1984-; Espinar, Lorena; Díez Antón, Juana, 1962-; Carey, Lucas, 1980-; Albà Soler, Mar (Nature Research, 2021)
    De novo gene origination has been recently established as an important mechanism for the formation of new genes. In organisms with a large genome, intergenic and intronic regions provide plenty of raw material for new ...

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