Browsing by Author "Espinar, Lorena"

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  • An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape
    Pokusaeva, Victoria O.; Usmanova, Dinara R.; Putintseva, Ekaterina V.; Espinar, Lorena; Sarkisyan, Karen S.; Mishin, Alexander S.; Bogatyreva, Natalya S.; Ivankov, Dmitry N.; Akopyan, Arseniy V.; Avvakumov, Sergey Ya; Povolotskaya, Inna, 1986-; Filion, Guillaume; Carey, Lucas, 1980-; Kondrashov, Fyodor A., 1979- (Public Library of Science (PLoS), 2019)
    Characterizing the fitness landscape, a representation of fitness for a large set of genotypes, is key to understanding how genetic information is interpreted to create functional organisms. Here we determined the ...
  • Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple-negative breast cancer
    Pascual-Reguant, Laura; Datta, Debayan; Cianferoni, Damiano; Kourtis, Savvas; Gañez-Zapater, Antoni; Cannatá, Chiara; Espinar, Lorena; García López, Laura; Musa-Afaneh, Sara; Guirola, Maria; Gkanogiannis, Anestis; Miró Canturri, Andrea; Arribas, Joaquín; Serrano Pubull, Luis, 1982-; Sdelci, Sara (EMBO Press, 2023)
    Triple-negative breast cancer (TNBC) often develops resistance to single-agent treatment, which can be circumvented using targeted combinatorial approaches. Here, we demonstrate that the simultaneous inhibition of LOXL2 ...
  • Promoter architecture determines cotranslational regulation of mRNA
    Espinar, Lorena; Schikora Tamarit, Miquel Àngel; Domingo Espinós, Júlia, 1991-; Carey, Lucas, 1980- (Cold Spring Harbor Laboratory Press (CSHL Press), 2018)
    Information that regulates gene expression is encoded throughout each gene but if different regulatory regions can be understood in isolation, or if they interact, is unknown. Here we measure mRNA levels for 10,000 open ...
  • Reversible and noisy progression towards a commitment point enables adaptable and reliable cellular decision-making
    Kuchina, Anna; Espinar, Lorena; García Ojalvo, Jordi; Süel, Gürol M. (Public Library of Science (PLoS), 2011)
    Cells must make reliable decisions under fluctuating extracellular conditions, but also be flexible enough to adapt to such changes. How cells reconcile these seemingly contradictory requirements through the dynamics of ...
  • Slow-growing cells within isogenic populations have increased RNA polymerase error rates and DNA damage
    Dijk, David van; Dhar, Riddhiman; Missarova, Alsu, 1990-; Espinar, Lorena; Blevins, William Robert, 1987-; Lehner, Ben, 1978-; Carey, Lucas, 1980- (Nature Publishing Group, 2015)
    Isogenic cells show a large degree of variability in growth rate, even when cultured in the same environment. Such cell-to-cell variability in growth can alter sensitivity to antibiotics, chemotherapy and environmental ...
  • Strand asymmetry influences mismatch resolution during a single-strand annealing
    Pokusaeva, Victoria O.; Rosado Diez, Aránzuru; Espinar, Lorena; Torelló Pérez, Albert; Filion, Guillaume (BioMed Central, 2022)
    Background: Biases of DNA repair can shape the nucleotide landscape of genomes at evolutionary timescales. The molecular mechanisms of those biases are still poorly understood because it is difficult to isolate the ...
  • Temporal competition between differentiation programs determines cell fate choice
    Kuchina, Anna; Espinar, Lorena; Cagatay, Tolga; Balbin, Alejandro O.; Zhang, Fang; Alvarado, Alma; García Ojalvo, Jordi; Süel, Gürol M. (Nature Publishing Group, 2011)
    Multipotent differentiation, where cells adopt one of several possible fates, occurs in diverse systems ranging from bacteria to mammals. This decision-making process is driven by multiple differentiation programs that ...
  • Uncovering de novo gene birth in yeast using deep transcriptomics
    Blevins, William Robert, 1987-; Ruiz Orera, Jorge, 1988-; Messeguer, Xavier; Blasco Moreno, Bernat, 1986-; Villanueva Cañas, José Luis, 1984-; Espinar, Lorena; Díez Antón, Juana, 1962-; Carey, Lucas, 1980-; Albà Soler, Mar (Nature Research, 2021)
    De novo gene origination has been recently established as an important mechanism for the formation of new genes. In organisms with a large genome, intergenic and intronic regions provide plenty of raw material for new ...

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