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Browsing by Author "Elosua Llanos, Roberto"

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A clinical-genetic approach to assessing cardiovascular risk in patients with CKD

Rodrigo, Emilio; Pich, Sara; Subirana Cachinero, Isaac; Fernandez-Fresnedo, Gema; Barreda Monteoliva, Paloma; Ferrer-Costa, Carles; de Francisco, Angel Luis M.; Salas, Eduardo; Elosua Llanos, Roberto; Arias, Manuel (Oxford University Press, 2017)

BACKGROUND: Coronary heart disease (CHD) is the primary cause of death in individuals with chronic kidney disease (CKD), but current equations for assessing coronary risk have low accuracy in this group. We have reported ...
A European benchmarking system to evaluate in-hospital mortality rates in acute coronary syndrome: The EURHOBOP project.

Dégano, Irene R.; Subirana Cachinero, Isaac; Torre, Marina; Grau Magaña, Maria; Vila, Joan; Fusco, Danilo; Kirchberger, Inge; Ferrières, Jean; Malmivaara, Antti; Azevedo, Ana; Meisinger, Christa; Bongard, Vanina; Farmakis, Dimitrios; Davoli, Marina; Häkkinen, Unto; Araújo, Carla; Lekakis, John; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume (Elsevier, 2015)

BACKGROUND: Hospital performance models in acute myocardial infarction (AMI) are useful to assess patient management. While models are available for individual countries, mainly US, cross-European performance models are ...
A missense variant in mitochondrial amidoxime reducing component 1 gene and protection against liver disease

Emdin, Connor A.; Elosua Llanos, Roberto; Kathiresan, Sekar (Public Library of Science (PLoS), 2020)

Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime Reducing Component 1 gene (MARC1 p.A165T) that associates with ...
Analysis of gene-gene interactions among common variants in candidate cardiovascular genes in coronary artery disease

Musameh, Muntaser D.; Wang, William Y. S.; Nelson, Christopher P.; Lluís Ganella, Carla, 1984-; Debiec, Radoslaw; Subirana Cachinero, Isaac; Elosua Llanos, Roberto; Balmforth, Anthony J.; Ball, Stephen G.; Hall, Alistair S.; Kathiresan, Sekar; Thompson, John R.; Lucas, Gavin, 1977-; Samani, Nilesh J.; Tomaszewski, Maciej (Public Library of Science, 2015)

OBJECTIVE: Only a small fraction of coronary artery disease (CAD) heritability has been explained by common variants identified to date. Interactions between genes of importance to cardiovascular regulation may account for ...
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease

Emdin, Connor A.; Elosua Llanos, Roberto; Kathiresan, Sekar (Nature Research, 2018)

Less than 3% of protein-coding genetic variants are predicted to result in loss of protein function through the introduction of a stop codon, frameshift, or the disruption of an essential splice site; however, such predicted ...
Analysis of protein-coding genetic variation in 60,706 humans

Lek, Monkol; Elosua Llanos, Roberto; MacArthur, Daniel G.; Exome Aggregation Consortium (Macmillan Publishers, 2016)

Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNA sequence changes. Here we describe the aggregation and analysis of high-quality exome (protein-coding ...
Anthracycline-induced cardiotoxicity in diffuse large B-cell lymphoma: NT-proBNP and cardiovascular score for risk stratification

Gimeno Vázquez, Eva; Subirana Cachinero, Isaac; Gómez Pérez, Miguel Angel; Díaz, Javier; Sanchez Gonzalez, Blanca; García-Pallarols, Francesc; Martínez, Laia; Ble, Mireia; Molina Ferragut, Luis; Belarte Tornero, Laia Carla; Abella Monreal, Eugenia; Elosua Llanos, Roberto; Comín Colet, Josep; Salar Silvestre, Antonio (Wiley, 2019)

OBJECTIVE: To evaluate the role of N-terminal pro-brain-type natriuretic peptide (NT-proBNP) and a cardiovascular (CV) risk score named FRESCO for predicting anthracycline-induced cardiotoxicity (AIC) in diffuse large ...
Association between chronic immune-mediated inflammatory diseases and cardiovascular risk

Baena Díez, Jose M.; Garcia Gil, Maria; Comas Cufí, Marc; Ramos, Rafel; Prieto-Alhambra, Daniel; Salvador-González, Betlem; Elosua Llanos, Roberto; Dégano, Irene R.; Peñafiel Muñoz, Judith; Grau Magaña, Maria (BMJ Publishing Group, 2017)
Association between DNA methylation and coronary heart disease or other atherosclerotic events: A systematic review

Fernández Sanlés, Alba, 1988-; Sayols, Sergi; Subirana Cachinero, Isaac; Dégano, Irene R.; Elosua Llanos, Roberto (Elsevier, 2017)

BACKGROUND AND AIMS: The aim of this study was to perform a systematic review of the association between DNA methylation and coronary heart disease (CHD) or related atherosclerotic traits. METHODS: A systematic review was ...
Association between genetic variants in FADS1-FADS2 and ELOVL2 and obesity, lipid traits, and fatty acids in Tunisian population

Khamlaoui, Wided; Mehri, Sounira; Hammami, Sonia; Hammouda, Souha; Chraeif, Imed; Elosua Llanos, Roberto; Hammami, Mohamed (SAGE Publications, 2020)

The aim of this study was to determine whether genetic variants in FADS1/FADS2 and ELOVL2 are associated with overweight-obesity and body mass index (BMI) and to assess the association between these genetic variants and ...
Association between long-term air pollution exposure and DNA methylation: The REGICOR study

Sayols, Sergi; Fernández Sanlés, Alba, 1988-; Prats Uribe, Albert; Subirana Cachinero, Isaac; Plusquin, Michelle; Künzli, Nino; Marrugat de la Iglesia, Jaume; Basagaña Flores, Xavier; Elosua Llanos, Roberto (Elsevier, 2019)

INTRODUCTION: Limited evidence suggests that epigenetic mechanisms may partially mediate the adverse effects of air pollution on health. Our aims were to identify new genomic loci showing differential DNA methylation ...
Association between long-term exposure to traffic-related air pollution and subclinical atherosclerosis: the REGICOR study

Rivera, Marcela, 1982-; Basagaña Flores, Xavier; Aguilera Jiménez, Inmaculada, 1977-; Foraster Pulido, Maria, 1984-; Agis, David; Groot, Eric de; Pérez Grau, Laura; Mendez, Michelle A.; Bouso, Laura; Targa, Jaume; Ramos, Rafel; Sala, Joan; Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto; Künzli, Nino (National Institute of Environmental Health Sciences (NIEHS), 2013)

BACKGROUND: Epidemiological evidence of the effects of long-term exposure to air pollution on the chronic processes of atherogenesis is limited. OBJECTIVE: We investigated the association of long-term exposure to traffic-related ...
Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population

Khamlaoui, Wided; Mehri, Sounira; Hammami, Sonia; Elosua Llanos, Roberto; Hammami, Mohamed (SAGE Publications, 2020)

Objective: This study aims to determine whether genetic variants in ACE I/D and AGT M235T are associated with overweight-obesity and body mass index (BMI) in a Tunisian population. Methods: We designed an age- and sex-matched ...
Association of apolipoprotein E with intracerebral hemorrhage risk by race/ethnicity: a meta-analysis

Marini, Sandro; Roquer, Jaume; Jiménez Conde, Jordi; Giralt-Steinhauer, Eva; Elosua Llanos, Roberto; Cuadrado-Godia, Elisa; Soriano Tarraga, Carolina; Anderson, Christopher D.; International Stroke Genetics Consortium (American Medical Association, 2019)

Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic ...
Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: the REGICOR Study

Dégano, Irene R.; Camps-Vilaró, Anna; Subirana Cachinero, Isaac; García-Mateo, Nadia; Cidad, Pilar; Muñoz Aguayo, Daniel; Puigdecanet Riubugent, Eulàlia; Nonell Mazelón, Lara; Vila, Joan; Crepaldi, Felipe M.; Gonzalo-Calvo, David de; Llorente-Cortés, Vicenta; Pérez García, María Teresa; Elosua Llanos, Roberto; Fitó Colomer, Montserrat; Marrugat de la Iglesia, Jaume (MDPI, 2020)

Risk prediction tools cannot identify most individuals at high coronary artery disease (CAD) risk. Oxidized low-density lipoproteins (oxLDLs) and microRNAs are actively involved in atherosclerosis. Our aim was to examine ...
Association of increased monetary cost of dietary intake, diet quality and weight management in Spanish adults.

Schröder, Helmut, 1958-; Serra-Majem, Luis; Subirana Cachinero, Isaac; Izquierdo Pulido, Maria; Fitó Colomer, Montserrat; Elosua Llanos, Roberto (Cambridge University Press, 2016)

Higher monetary diet cost is associated with healthier food choices and better weight management. How changes in diet cost affect changes in diet quality and weight remains unknown. The aim of this study was to assess the ...
Association of long-term exposure to traffic-related air pollution with blood pressure and hypertension in an adult population-based cohort in Spain (the REGICOR study)

Foraster Pulido, Maria, 1984-; Basagaña Flores, Xavier; Aguilera Jiménez, Inmaculada, 1977-; Rivera, Marcela, 1982-; Agis, David; Bouso, Laura; Deltell, Alexandre; Marrugat de la Iglesia, Jaume; Ramos, Rafel; Sunyer Deu, Jordi; Vila, Joan; Elosua Llanos, Roberto; Künzli, Nino (National Institute of Environmental Health Sciences (NIEHS), 2014)

Background: Long-term exposure to traffic-related air pollution may increase blood pressure (BP) and induce hypertension. However, evidence supporting these associations is limited, and they may be confounded by exposure ...
Base of the triangle to determine a Brugada electrocardiogram pattern.

Serra, Guillem; Baranchuk, Adrian; Bayés-De-Luna, Antoni; Brugada, Josep; Goldwasser, Diego; Capulzini, Lucio; Arazo, David; Boraita, Araceli; Heras, Maria-Eugenia; Garcia-Niebla, Javier; Elosua Llanos, Roberto; Brugada, Ramón; Brugada, Pedro (Oxford University Press, 2015)
Benefit of primary percutaneous coronary interventions in the elderly with ST segment elevation myocardial infarction

Fernández-Bergés, Daniel; Dégano, Irene R.; Subirana Cachinero, Isaac; Martí-Almor, Julio; Vila, Joan; Pérez-Fernández, Silvia; Martí-Almor, Julio; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume; ATHOS investigators (BMJ Publishing Group, 2020)

Objective: Primary percutaneous coronary intervention (P-PCI) has demonstrated its efficacy in patients with ST segment elevation myocardial infarction (STEMI). However, patients with STEMI ≥75 years receive less P-PCI ...
Cardiovascular Risk Factors and Ischemic Heart Disease: Is the Confluence of Risk Factors Greater Than the Parts? A Genetic Approach

Elosua Llanos, Roberto; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Havulinna, Aki; Läll, Kristi; Lucas, Gavin, 1977-; Sayols, Sergi; Pietilä, Arto; Alver, Maris; Cabrera de León, Antonio; Sentí Clapés, Mariano; Siscovick, David; Mellander, Olle; Fischer, Krista; Salomaa, Veikko; Marrugat de la Iglesia, Jaume (Lippincott Williams & Wilkins, 2016)

BACKGROUND: Cardiovascular risk factors tend to aggregate. The biological and predictive value of this aggregation is questioned and genetics could shed light on this debate. Our aims were to reappraise the impact of risk ...

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Browsing by Author "Elosua Llanos, Roberto"

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