Browsing by Author "Elek, Anamaria"

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  • A stony coral cell atlas illuminates the molecular and cellular basis of coral symbiosis, calcification, and immunity
    Levy, Shani; Elek, Anamaria; Grau Bové, Xavier; Menéndez Bravo, Simón; Iglesias, Marta; Tanay, Amos; Mass, Tali; Sebé-Pedrós, Arnau (Elsevier, 2021)
    Stony corals are colonial cnidarians that sustain the most biodiverse marine ecosystems on Earth: coral reefs. Despite their ecological importance, little is known about the cell types and molecular pathways that underpin ...
  • ACME dissociation: a versatile cell fixation-dissociation method for single-cell transcriptomics
    García-Castro, Helena; Kenny, Nathan J.; Iglesias, Marta; Álvarez Campos, Patricia; Mason, Vincent; Elek, Anamaria; Schönauer, Anna; Sleight, Victoria A.; Neiro, Jakke; Aboobaker, Aziz; Permanyer, Jon; Irimia Martínez, Manuel; Sebé-Pedrós, Arnau; Solana, Jordi (BioMed Central, 2021)
    Single-cell sequencing technologies are revolutionizing biology, but they are limited by the need to dissociate live samples. Here, we present ACME (ACetic-MEthanol), a dissociation approach for single-cell transcriptomics ...
  • An amphioxus neurula stage cell atlas supports a complex scenario for the emergence of vertebrate head mesoderm
    Grau Bové, Xavier; Subirana, Lucie; Meister, Lydvina; Soubigou, Anaël; Neto, Ana; Elek, Anamaria; Naranjo, Silvia; Fornas Carreño, Oscar; Gómez Skarmeta, José Luis; Tena, Juan J.; Irimia Martínez, Manuel; Bertrand, Stéphanie; Sebé-Pedrós, Arnau; Escriva, Hector (Nature Research, 2024)
    The emergence of new structures can often be linked to the evolution of novel cell types that follows the rewiring of developmental gene regulatory subnetworks. Vertebrates are characterized by a complex body plan compared ...
  • cGLRs are a diverse family of pattern recognition receptors in innate immunity
    Li, Yao; Slavik, Kailey M.; Toyoda, Hunter C.; Morehouse, Benjamin R.; Oliveira Mann, Carina C. de; Elek, Anamaria; Levy, Shani; Wang, Zhenwei; Mears, Kepler S.; Liu, Jingjing; Kashin, Dmitry; Guo, Ximing; Mass, Tali; Sebé-Pedrós, Arnau; Schwede, Frank; Kranzusch, Philip J. (Elsevier, 2023)
    Cyclic GMP-AMP synthase (cGAS) is an enzyme in human cells that controls an immune response to cytosolic DNA. Upon binding DNA, cGAS synthesizes a nucleotide signal 2'3'-cGAMP that activates STING-dependent downstream ...
  • Modeling cell type evolution using single-cell and chromatin profiling approaches
    Elek, Anamaria (Universitat Pompeu Fabra, 2024-04-26)
    Single-cell genomics methods have revolutionized the study of gene expression and regulation at the cell type level. Generating single-cell atlases for species at key phylogenetic positions of the animal tree of life (e.g.. ...
  • Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster
    Miguel Escalada, Irene; Maestro, Miguel Ángel; Balboa, Diego; Elek, Anamaria; Bernal, Aina; Bernardo, Edgar; Grau, Vanessa; García-Hurtado, Javier; Sebé-Pedrós, Arnau; Ferrer, Jorge (Elsevier, 2022)
    Sequence variants in cis-acting enhancers are important for polygenic disease, but their role in Mendelian disease is poorly understood. Redundancy between enhancers that regulate the same gene is thought to mitigate the ...
  • Stepwise emergence of the neuronal gene expression program in early animal evolution
    Najle, Sebastián R.; Grau Bové, Xavier; Elek, Anamaria; Navarrete Hernández, Cristina; Cianferoni, Damiano; Chiva, Cristina; Cañas Armenteros, Didac; Mallabiabarrena, Arrate; Kamm, Kai; Sabidó Aguadé, Eduard, 1981-; Gruber-Vodicka, Harald; Schierwater, Bernd; Serrano Pubull, Luis, 1982-; Sebé-Pedrós, Arnau (Elsevier, 2023)
    The assembly of the neuronal and other major cell type programs occurred early in animal evolution. We can reconstruct this process by studying non-bilaterians like placozoans. These small disc-shaped animals not only have ...

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