Browsing by Author "Eizirik, Décio L."

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  • An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
    Colli, Maikel Luis; Ramos-Rodríguez, Mireia; Raurell Vila, Helena; Pasquali, Lorenzo; Eizirik, Décio L. (Nature Research, 2020)
    Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D genetic risk variants and viral infections associated with T1D. We ...
  • The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
    Ramos-Rodríguez, Mireia; Raurell Vila, Helena; Colli, Maikel Luis; Alvelos, Maria Inês; Subirana-Granés, Marc; Juan-Mateu, Jonàs; Norris, Richard; Turatsinze, Jean-Valery; Nakayasu, Ernesto S.; Webb-Robertson, Bobbie-Jo M.; Inshaw, Jamie R. J.; Marchetti, Piero; Piemonti, Lorenzo; Esteller, Manel; Todd, John A.; Metz, Thomas O.; Eizirik, Décio L.; Pasquali, Lorenzo (Nature Research, 2019)
    The early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show that exposure to proinflammatory cytokines reveals a ...
  • The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells
    Alvelos, Maria Inês; Brüggemann, Mirko; Sutandy, Fx Reymond; Juan-Mateu, Jonàs; Colli, Maikel Luis; Busch, Anke; Lopes, Miguel; Castela, Ângela; Aartsma-Rus, Annemieke; König, Julian; Zarnack, Kathi; Eizirik, Décio L. (Life Science Alliance, 2020)
    In pancreatic β-cells, the expression of the splicing factor SRSF6 is regulated by GLIS3, a transcription factor encoded by a diabetes susceptibility gene. SRSF6 down-regulation promotes β-cell demise through splicing ...
  • The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α
    Chandra, Vikash; Ibrahim, Hazem; Halliez, Clémentine; Prasad, Rashmi B.; Vecchio, Federica; Dwivedi, Om Prakash; Kvist, Jouni; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam; Barsby, Tom; Lithovius, Väinö; Artner, Isabella; Gopalakrishnan, Swetha; Groop, Leif; Mallone, Roberto; Eizirik, Décio L.; Otonkoski, Timo (Nature Research, 2022)
    Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2, which encodes a Janus kinase with critical roles in ...