Browsing by Author "Dzierzak, Elaine"

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  • Blood Development: Hematopoietic Stem Cell Dependence and Independence
    Dzierzak, Elaine; Bigas Salvans, Anna (Elsevier, 2018)
    Evidence of the diversity and multi-layered organization of the hematopoietic system is leading to new insights that may inform ex vivo production of blood cells. Interestingly, not all long-lived hematopoietic cells derive ...
  • Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence
    Islam, Abul, 1978-; Guiu Sagarra, Jordi, 1983-; Bergen, Dylan J.M.; de Pater, Emma; Ayllon, Verónica; Gama-Norton, Leonor; Ruiz Herguido, Cristina; González, Jessica; López Bigas, Núria; Menéndez, Pablo; Dzierzak, Elaine; Espinosa Blay, Lluís; Bigas Salvans, Anna (Rockefeller University Press, 2014)
    Hematopoietic stem cell (HSC) specification occurs in the embryonic aorta and requires Notch activation; however, most of the Notch-regulated elements controlling de novo HSC generation are still unknown. Here, we identify ...
  • Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation
    Porcheri, Cristina; Golan, Ohad; Calero-Nieto, Fernando J.; Thambyrajah, Roshana; Ruiz-Herguido, Cristina; Wang, Xiaonan; Catto, Francesca; Guillén, Yolanda; Sinha, Roshani, 1989-; González, Jessica; Kinston, Sarah J.; Mariani, Samanta A.; Maglitto, Antonio; Vink, Chris S.; Dzierzak, Elaine; Charbord, Pierre; Göttgens, Bertie; Espinosa Blay, Lluís; Sprinzak, David; Bigas Salvans, Anna (Wiley-Blackwell, 2020)
    Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium in cluster structures that protrude into the embryonic aortic lumen. Although much is known about the molecular characteristics of the developing ...