Browsing by Author "Duch, Alba"

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  • A novel mechanism for the prevention of transcription replication conflicts
    Canal de Torres, Berta, 1988-; Duch, Alba; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Taylor & Francis, 2018)
    Transcription and replication complexes can coincide in space and time. Such coincidences may result in collisions that trigger genomic instability. The phosphorylation of Mrc1 by different signaling kinases is part of a ...
  • Dealing with transcriptional outbursts during S phase to protect genomic integrity
    Duch, Alba; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Elsevier, 2013)
    Transcription during S phase needs to be spatially and temporally regulated to prevent collisions between the transcription and replication machineries. Cells have evolved a number of mechanisms to make both processes ...
  • Hog1 activation delays mitotic exit via phosphorylation of Net1
    Tognetti, Silvia; Jiménez, Javier; Viganò, Matteo; Duch, Alba; Queralt Badia, Ethel; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (National Academy of Sciences, 2020)
    Adaptation to environmental changes is crucial for cell fitness. In Saccharomyces cerevisiae, variations in external osmolarity trigger the activation of the stress-activated protein kinase Hog1 (high-osmolarity glycerol ...
  • Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
    Duch, Alba; Canal de Torres, Berta, 1988-; Barroso, Sonia I.; García Rubio, María Luisa; Seisenbacher, Gerhard; Aguilera, Andrés; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Nature Publishing Group, 2018)
    Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have evolved strategies to prevent such conflicts. However, little is known regarding how cells cope ...
  • The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms
    Ruiz Roig, Clàudia; Noriega Esteban, Núria; Duch, Alba; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (American Society for Cell Biology, 2012)
    Cells modulate expression of nuclear genes in response to alterations in mitochondrial function, a response termed retrograde (RTG) regulation. In budding yeast, the RTG pathway relies on Rtg1 and Rtg3 basic helix-loop-helix ...

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