Browsing by Author "Dubus, Pierre"

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  • Essential role of the N-terminal region of TFII-I in viability and behavior
    Lucena, Jaume; Pezzi, Susana; Aso Pérez, Ester; Valero, Maria C.; Carreiro, Candelas; Dubus, Pierre; Sampaio, Adriana; Segura Puimedon, Maria, 1985-; Barthelemy, Isabel; Zindel, Marc Y.; Sousa, Nuno; Barbero, José L.; Maldonado, Rafael, 1961-; Pérez Jurado, Luis Alberto; Campuzano Uceda, María Victoria (BioMed Central, 2010)
    Background: GTF2I codes for a general intrinsic transcription factor and calcium channel regulator TFII-I, with high and ubiquitous expression, and a strong candidate for involvement in the morphological and neuro-developmental ...
  • Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.
    Martin, Alberto, 1974-; Salvador, Fernando; Moreno-Bueno, Gema; Floristán, Alfredo; Ruiz Herguido, Cristina; Cuevas, Eva P. Cuevas; Morales, Saleta; Santos, Vanessa Sonia; Csiszar, Katalin; Dubus, Pierre; Haigh, Jody J.; Bigas Salvans, Anna; Portillo, Francisco; Cano, Amparo (EMBO Press, 2015)
    Lysyl oxidase-like 2 (LOXL2) is involved in a wide range of physiological and pathological processes, including fibrosis and tumor progression, implicating intracellular and extracellular functions. To explore the specific ...
  • Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development
    Mijimolle, Nieves; Velasco, Juan; Dubus, Pierre; Guerra, Carmen; Weinbaum, Carolyn A.; Casey, Patrick J.; Campuzano Uceda, María Victoria; Barbacid, Mariano (Elsevier, 2005)
    Protein farnesyltransferase (FTase) is an enzyme responsible for posttranslational modification of proteins carrying a carboxy-terminal CaaX motif. Farnesylation allows substrates to interact with membranes and protein ...
  • Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context
    Guerra, Carmen; Mijimolle, Nieves; Dhawahir, Alma; Dubus, Pierre; Barradas, Marta; Serrano, Manuel; Campuzano Uceda, María Victoria; Barbacid, Mariano (Elsevier, 2003)
    We have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-Ras(V12) oncoprotein along with a marker protein (beta-geo) from a single bicistronic transcript. Expression of this oncogenic allele requires ...

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