Browsing by Author "Duñach, Mireia"

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  • Casagolda, David; Valle Pérez, Beatriz del; Valls, Gabriela; Lugilde, Ero; Vinyoles, Meritxell; Casado Vela, Juan; Solanas, Guiomar; Batlle Gómez, Eduard; Reynolds, Albert B.; Casal, José Ignacio; García de Herreros, Antonio; Duñach, Mireia (Company of Biologists, 2010)
    p120-catenin is an E-cadherin-associated protein that modulates E-cadherin function and stability. We describe here that p120-catenin is required for Wnt pathway signaling. p120-catenin binds and is phosphorylated by CK1ε ...
  • Vinyoles, Meritxell; Valle Pérez, Beatriz del; Curto, Josué; Padilla, Mary; Villarroel, Aida; Yang, J.Y.; García de Herreros, Antonio; Duñach, Mireia (Springer Nature, 2017)
    Canonical Wnt signaling induces the stabilization of β-catenin, its translocation to the nucleus and the activation of target promoters. This pathway is initiated by the binding of Wnt ligands to the Frizzled receptor, the ...
  • Curto, Josué; Valle Pérez, Beatriz del; Villarroel, Aida; Fuertes, Guillem; Vinyoles, Meritxell; Peña, Raúl; García de Herreros, Antonio; Duñach, Mireia (Wiley, 2018)
    Canonical and noncanonical Wnt pathways share some common elements but differ in the responses they evoke. Similar to Wnt ligands acting through the canonical pathway, Wnts that activate the noncanonical signaling, such ...
  • Valle Pérez, Beatriz del; Casagolda, David; Lugilde, Ero; Valls, Gabriela; Codina, Montserrat; Dave, Natàlia; García de Herreros, Antonio; Duñach, Mireia (Company of Biologists, 2016)
    There was an error published in J. Cell Sci. 124, 2298–2309.
  • Mestre-Farrera, Aida, 1992-; Bruch-Oms, Marina; Peña Arranz, Raúl, 1976-; Rodríguez-Morató, Jose, 1987-; Alba Castellón, Lorena, 1984-; Comerma Blesa, Laura, 1983-; Quintela-Fandino, Miguel; Duñach, Mireia; Baulida i Estadella, Josep, 1965-; Pozo Mendoza, Óscar J., 1975-; García de Herreros, Antonio (American Association for Cancer Research (AACR), 2021)
    Tumors are complex tissues composed of transformed epithelial cells as well as cancer-activated fibroblasts (CAF) that facilitate epithelial tumor cell invasion. We show here that CAFs and other mesenchymal cells rely much ...
  • García de Herreros, Antonio; Duñach, Mireia (MDPI, 2019)
    In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which is a prerequisite for formation of the TCF4/β-catenin transcriptional complex and activation of its target genes. This ...
  • Vinyoles, Meritxell; Valle Pérez, Beatriz del; Curto, Josué; Viñas Castells, Rosa, 1985-; Alba Castellón, Lorena, 1984-; García de Herreros, Antonio; Duñach, Mireia (Elsevier, 2014)
    The Wnt canonical ligands elicit the activation of β-catenin transcriptional activity, a response dependent on, but not limited to, β-catenin stabilization through the inhibition of GSK3 activity. Two mechanisms have been ...
  • Fuertes, Guillem; Valle Pérez, Beatriz del; Pastor Ruiz, Javier; Andrades, Evelyn; Peña Arranz, Raúl, 1976-; García de Herreros, Antonio; Duñach, Mireia (EMBO Press, 2023)
    Colon tumors of the mesenchymal subtype have the lowest overall survival. Snail1 is essential for the acquisition of this phenotype, characterized by increased tumor stemness and invasion, and high resistance to chemotherapy. ...
  • Valls, Gabriela; Codina, Montserrat; Miller, Rachel K.; Valle Pérez, Beatriz del; Vinyoles, Meritxell; Caelles Franch, Carme; McCrea, Pierre D.; García de Herreros, Antonio; Duñach, Mireia (Company of Biologists, 2012)
    A role for Rac1 GTPase in canonical Wnt signaling has recently been demonstrated, showing that it is required for β-catenin translocation to the nucleus. In this study, we investigated the mechanism of Rac1 stimulation by ...
  • Valle Pérez, Beatriz del; Casagolda, David; Lugilde, Ero; Valls, Gabriela; Codina, Montserrat; Dave, Natàlia; García de Herreros, Antonio; Duñach, Mireia (Company of Biologists, 2011)
    p120-catenin is an E-cadherin-associated protein that modulates E-cadherin function and stability. In response to Wnt3a, p120-catenin is phosphorylated at Ser268 and Ser269, disrupting its interaction with E-cadherin. Here, ...

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