Browsing by Author "Domínguez, Orlando"

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  • ARID1A alterations are associated with FGFR3-wild type, poor-prognosis, urothelial bladder tumors
    Balbás Martínez, Cristina; Rodríguez Pinilla, María; Casanova, Ariel; Domínguez, Orlando; Pisano, David G.; Gómez López, Gonzalo; Lloreta Trull, Josep, 1958-; Lorente Garin, José Antonio; Malats i Riera, Núria; Real, Francisco X. (Public Library of Science (PLoS), 2013)
    Urothelial bladder cancer (UBC) is heterogeneous at the clinical, pathological, genetic, and epigenetic levels. Exome sequencing has identified ARID1A as a novel tumor suppressor gene coding for a chromatin remodeling ...
  • Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity
    Santos, Catarina P.; Lapi, Eleonora; Martínez de Villarreal, Jaime; Álvaro-Espinosa, Laura; Fernández-Barral, Asunción; Barbáchano, Antonio; Domínguez, Orlando; Laughney, Ashley M.; Megías, Diego; Muñoz, Alberto; Real, Francisco X. (Nature Research, 2019)
    Understanding urothelial stem cell biology and differentiation has been limited by the lack of methods for their unlimited propagation. Here, we establish mouse urothelial organoids that can be maintained uninterruptedly ...
  • Vitamin D differentially regulates colon stem cells in patient-derived normal and tumor organoids
    Fernández-Barral, Asunción; Costales-Carrera, Alba; Buira, Sandra P.; Jung, Peter; Ferrer Mayorga, Gemma; Larriba, María Jesús; Bustamante-Madrid, Pilar; Domínguez, Orlando; Real, Francisco X.; Guerra Pastrián, Laura; Lafarga, Miguel; García-Olmo, Damián; Cantero, Ramón; Del Peso, Luis; Batlle Gómez, Eduard; Rojo, Federico; Muñoz, Alberto; Barbáchano, Antonio (Wiley-Blackwell, 2019)
    Intestine is a major target of vitamin D and several studies indicate an association between vitamin D deficiency and inflammatory bowel diseases (IBD), but also increased colorectal cancer (CRC) risk and mortality. However, ...
  • Whole genome analysis of p38 SAPK-mediated gene expression upon stress
    Ferreiro Neira, Isabel; Joaquin i Caudet, Manel; Islam, Abul, 1978-; Gómez López, Gonzalo; Barragan, Montserrat; Lombardía, Luís; Domínguez, Orlando; Pisano, David G.; López Bigas, Núria; Nebreda, Ángel R.; Posas Garriga, Francesc (BioMed Central, 2010)
    Background: Cells have the ability to respond and adapt to environmental changes through activation of stress-activated protein kinases (SAPKs). Although p38 SAPK signalling is known to participate in the regulation of ...