Browsing by Author "Doñate-Macián, Pau"

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  • A TRPV2 interactome-based signature for prognosis in glioblastoma patients
    Doñate-Macián, Pau; Gómez, Antonio; Dégano, Irene R.; Perálvarez Marín, Alex (Impact Journal, 2018)
    Proteomics aids to the discovery and expansion of protein-protein interaction networks, which are key to understand molecular mechanisms in physiology and physiopathology, but also to infer protein function in a ...
  • Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel
    Berna Erro, Alejandro; Izquierdo Serra, Mercè; Sepúlveda, Romina V.; Rubio Moscardó, Fanny; Doñate-Macián, Pau; Serra Pascual, Selma A., 1981-; Carrillo García, Julia, 1993-; Perálvarez Marín, Alex; González Nilo, Fernando; Fernández-Fernández, José Manuel, 1967-; Valverde, M. A. (Miguel Ángel), 1963- (Nature Publishing Group, 2017)
    TRPV4 cation channel activation by cytochrome P450-mediated derivatives of arachidonic acid (AA), epoxyeicosatrienoic acids (EETs), constitute a major mechanisms of endothelium-derived vasodilatation. Besides, TRPV4 ...
  • Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity
    Doñate-Macián, Pau; Duarte, Yorley; Rubio Moscardo, Fanny; Pérez Vilaró, Gemma, 1985-; Canan, Jonathan; Díez Antón, Juana, 1962-; González Nilo, Fernando; Valverde, M. A. (Miguel Ángel), 1963- (Wiley, 2022)
    Background and purpose: The transient receptor potential vanilloid 4 (TRPV4) cation channel participates in multiple physiological processes and is also at the core of different diseases, making this channel an interesting ...
  • The mechanosensitive Piezo1 channel controls endosome trafficking for an efficient cytokinetic abscission
    Carrillo García, Julia, 1993-; Herrera-Fernández, Víctor; Serra, Selma A.; Rubio Moscardó, Fanny; Vogel-González, Marina; Doñate-Macián, Pau; Hevia, Covadonga F.; Pujades Corbi, Cristina; Valverde, M. A. (Miguel Ángel), 1963- (American Association for the Advancement of Science (AAAS), 2021)
    Mechanical forces are exerted throughout cytokinesis, the final step of cell division. Yet, how forces are transduced and affect the signaling dynamics of cytokinetic proteins remains poorly characterized. We now show that ...
  • The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity
    Doñate-Macián, Pau; Jungfleisch, Jennifer, 1986-; Pérez Vilaró, Gemma, 1985-; Rubio Moscardó, Fanny; Perálvarez Marín, Alex; Díez Antón, Juana, 1962-; Valverde, M. A. (Miguel Ángel), 1963- (Nature Publishing Group, 2018)
    Ion channels are well placed to transduce environmental cues into signals used by cells to generate a wide range of responses, but little is known about their role in the regulation of RNA metabolism. Here we show that the ...
  • Trafficking of stretch-regulated TRPV2 and TRPV4 channels inferred through interactomics
    Doñate-Macián, Pau; Enrich-Bengoa, Jennifer; Dégano, Irene R.; Quintana, David G.; Perálvarez Marín, Alex (MDPI, 2019)
    Transient receptor potential cation channels are emerging as important physiological and therapeutic targets. Within the vanilloid subfamily, transient receptor potential vanilloid 2 (TRPV2) and 4 (TRPV4) are osmo- and ...

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