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Browsing by Author "Diez Pérez, Adolfo"
Now showing items 1-13 of 13
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Rufus-Membere, Pamela; Holloway-Kew, Kara L.; Diez Pérez, Adolfo; Kotowicz, Mark A.; Pasco, Julie A. (Oxford University Press, 2019)Impact microindentation (IMI) measures bone material strength index (BMSi) in vivo. However, clinical risk factors that affect BMSi are largely unknown. This study investigated associations between BMSi and clinical risk ...
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Valassi, Elena; García-Giralt, Natalia; Malouf Sierra, Jorge; Crespo, Iris; Llauger, Jaume; Diez Pérez, Adolfo; Webb, Susan M. (BioScientifica, 2019)Background Biochemical control of GH/IGF-I excess in acromegaly (ACRO) is associated with persistent impairment of trabecular microstructure leading to increased risk of vertebral fractures. Circulating miRNAs modulate the ...
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Herrera, Sabina; Diez Pérez, Adolfo (Elsevier, 2017)Densitometry and imaging techniques are currently used in clinical settings to measure bone quantity and spatial structure. Recently, Reference Point Indentation has opened the possibility of directly assessing the mechanical ...
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Martínez-Gil, Núria; Roca Ayats, Neus; Monistrol-Mula, Anna; García-Giralt, Natalia; Diez Pérez, Adolfo; Nogués Solan, Francesc Xavier; Mellibovsky, Leonardo; Grinberg, Daniel; Balcells, Susana (Nature Research, 2018)Numerous GWAS and candidate gene studies have highlighted the role of the Wnt pathway in bone biology. Our objective has been to study in detail the allelic architecture of three Wnt pathway genes: WNT16, DKK1 and SOST, ...
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Tebé, Cristian; Martínez-Laguna, Daniel; Moreno, Víctor; Cooper, Cyrus; Diez Pérez, Adolfo; Collins, Gary S.; Prieto-Alhambra, Daniel (Wiley, 2018)Type 2 diabetes (T2DM) is associated with a reduced life expectancy. The latest published evidence suggests an increased risk of fractures among T2DM patients. We conducted a population-based cohort study to determine the ...
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Diez Pérez, Adolfo; Marín, Fernando; Eriksen, Erik Fink; Kendler, David L.; Krege, John H.; Delgado Rodríguez, Miguel (Elsevier, 2019)In randomized clinical trials (RCTs) with teriparatide, the number of patients with incident hip fractures was small and insufficiently powered to show statistically significant differences between groups. We, therefore, ...
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Rufus-Membere, Pamela; Holloway-Kew, Kara L.; Diez Pérez, Adolfo; Kotowicz, Mark A.; Pasco, Julie A. (BMJ Publishing Group, 2018)OBJECTIVES: The OsteoProbe measures Bone Material Strength Index (BMSi) of cortical bone in living humans using impact microindentation (IMI). Research using this minimally invasive technique is expanding yet, to-date, ...
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Martínez-Laguna, Daniel; Tebé, Cristian; Nogués Solan, Francesc Xavier; Javaid, M. Kassim; Cooper, Cyrus; Diez Pérez, Adolfo; Collins, Gary S.; Prieto-Alhambra, Daniel (Public Library of Science (PLoS), 2018)BACKGROUND: An increased fracture risk has been described as a complication of Type 2 diabetes mellitus (T2DM). Clinical prediction models for general population have a limited predictive accuracy for fractures in T2DM ...
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Martínez-Gil, Núria; Roca Ayats, Neus; Atalay, Nurgül; Pineda-Moncusí, Marta; Garcia Giralt, Natàlia; Van Hul, Wim; Boudin, Eveline; Ovejero Crespo, Diana; Mellibovsky, Leonardo; Nogués Solan, Francesc Xavier; Diez Pérez, Adolfo; Grinberg, Daniel; Balcells, Susana (Wiley, 2020)The DKK1 gene encodes an extracellular inhibitor of the Wnt pathway with an important role in bone tissue development, bone homeostasis, and different critical aspects of bone biology. Several BMD genome-wide association ...
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Rufus-Membere, Pamela; Holloway-Kew, Kara L.; Kotowicz, Mark A.; Diez Pérez, Adolfo; Pasco, Julie A. (Wiley, 2020)Impact microindentation (IMI) is a novel technique for assessing the bone material strength index (BMSi) in vivo. However, no studies have presented normative data for BMSi. The aim of this study was to develop such normative ...
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Beaudart, Charlotte; Boonen, Annelies; Li, Nannan; Bours, Silvia; Goemaere, Stefan; Reginster, Jean-Yves; Roux, Christophe; McGowan, B.; Diez Pérez, Adolfo; Rizzoli, René; Cooper, Cyrus; Hiligsmann, Mickaël (Springer, 2022)Using a discrete choice experiment, we aimed to assess patients' preferences with regard to adopting lifestyle behaviours to prevent osteoporotic fractures. Overall, the 1042 patients recruited from seven European countries ...
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Diez Pérez, Adolfo; Thierry, Thomas (SpringerOpen, 2019)PURPOSE: The purpose of this paper was to review the available approaches for bone strength assessment, osteoporosis diagnosis and fracture risk prediction, and to provide insights into radiofrequency echographic multi ...
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Diez Pérez, Adolfo; Bouxsein, Mary L.; Eriksen, Erik Fink; Khosla, Sundeep; Nyman, Jeffry S.; Papapoulos, Socrates; Tang, Simon Y. (Elsevier, 2016)Impact microindentation is a novel method for measuring the resistance of cortical bone to indentation in patients. Clinical use of a handheld impact microindentation technique is expanding, highlighting the need to ...
Now showing items 1-13 of 13
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