Browsing by Author "Di Vona, Chiara, 1981-"

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  • A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response
    Roewenstrunk, Julia Maria, 1981-; Di Vona, Chiara, 1981-; Chen, Jie; Borràs, Eva; Dong, Chao; Arató, Krisztina, 1981-; Sabidó Aguadé, Eduard, 1981-; Huen, Michael S. Y.; Luna Gargantilla, Susana de la (Nature Research, 2019)
    Dysregulation of the DYRK1A protein kinase has been associated with human disease. On the one hand, its overexpression in trisomy 21 has been linked to certain pathological traits of Down syndrome, while on the other, ...
  • A novel CDC25A/DYRK2 regulatory switch modulates cell cycle and survival
    Lara-Chica, Maribel; Correa-Sáez, Alejandro; Jiménez-Izquierdo, Rafael; Garrido-Rodríguez, Martín; Ponce, Francisco J.; Moreno, Rita; Morrison, Kimberley; Di Vona, Chiara, 1981-; Arató, Krisztina, 1981-; Jiménez-Jiménez, Carla; Morrugares, Rosario; Schmitz, M. Lienhard; Luna, Susana de la; Vega, Laureano de la; Calzado, Marco A. (Nature Research, 2022)
    The cell division cycle 25A (CDC25A) phosphatase is a key regulator of cell cycle progression that acts on the phosphorylation status of Cyclin-Cyclin-dependent kinase complexes, with an emergent role in the DNA damage ...
  • An RNA polymerase III general transcription factor engages in cell type-specific chromatin looping
    De Llobet, Lara Isabel; Di Vona, Chiara, 1981-; Morselli, Marco; Vezzoli, Marco; Montanini, Barbara; Teichmann, Martin; de la Luna, Susana; Ferrari, Roberto (MDPI, 2022)
    Transcription factors (TFs) bind DNA in a sequence-specific manner and are generally cell type-specific factors and/or developmental master regulators. In contrast, general TFs (GTFs) are part of very large protein complexes ...
  • DYRK1A kinase positively regulates angiogenic responses in endothelial cells
    Rozen, Esteban J.; Roewenstrunk, Julia Maria, 1981-; Barallobre, María José; Di Vona, Chiara, 1981-; Jung, Carole; Figueiredo, Ana F.; Luna, Jeroni; Fillat i Fonts, Cristina; Arbonés de Rafael, Maria Lourdes, 1959-; Graupera, Mariona; Valverde, M. A. (Miguel Ángel), 1963-; Luna Gargantilla, Susana de la (Elsevier, 2018)
    Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells ...
  • Exploring the role of DYRK1A in RNA polymerase III transcription : DYRK1A as a potential regulator of TFIIIC
    Cort, Rianne Angelica, 1991- (Universitat Pompeu Fabra, 2019-12-13)
    The kinase DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a dosage-sensitive gene, since both haploinsufficiency and overexpression when in trisomy lead to pathological phenotypes in humans. In this Thesis, the ...
  • Nuclear DYRK1A :new insights into its role within the nucleus
    Di Vona, Chiara, 1981- (Universitat Pompeu Fabra, 2013-09-20)
    The view on how protein kinases regulate gene expression have recently expanded to include not only transcription factors but also histones, chromatin remodelers or components of the basal transcription machinery, which ...
  • TFIIIC as a potential epigenetic modulator of histone acetylation in human stem cells
    Vezzoli, Marco; De Llobet, Lara Isabel; Di Vona, Chiara, 1981-; Morselli, Marco; Montanini, Barbara; Luna Gargantilla, Susana de la; Teichmann, Martin; Dieci, Giorgio; Ferrari, Roberto (MDPI, 2023)
    Regulation of histone acetylation dictates patterns of gene expression and hence cell identity. Due to their clinical relevance in cancer biology, understanding how human embryonic stem cells (hESCs) regulate their genomic ...
  • TFIIIC binding to alu elements controls gene expression via chromatin looping and histone acetylation
    Ferrari, Roberto; De Llobet, Lara Isabel; Di Vona, Chiara, 1981-; Le Dily, François; Vidal Ocabo, Enrique; Lloutas, Antonios; Quilez Oliete, Javier; Jochem, Laura; Cuts, Erin; Dieci, Giorgio; Vannini, Alessandro; Teichmann, Martin; de la Luna, Susana; Beato, Miguel (Elsevier, 2020)
    How repetitive elements, epigenetic modifications, and architectural proteins interact ensuring proper genome expression remains poorly understood. Here, we report regulatory mechanisms unveiling a central role of Alu ...