Browsing by Author "Delgado García, José María"

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  • Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability
    Matamoros-Angles, Andreu; Hervera, Arnau; Soriano, Jordi; Martí, Eugènia; Carulla, Patricia; Llorens, Franc; Nuvolone, Mario; Aguzzi, Adriano; Ferrer, Isidre; Gruart, Agnès; Delgado García, José María; del Río, José Antonio (BioMed Central, 2022)
    Background: Cellular prion protein (PrPC) is a cell surface GPI-anchored protein, usually known for its role in the pathogenesis of human and animal prionopathies. However, increasing knowledge about the participation of ...
  • Microglial activation underlies cerebellar deficits produced by repeated cannabis exposure
    Cutando Ruiz, Laura, 1985-; Busquets Garcia, Arnau, 1985-; Puighermanal Puigvert, Emma, 1983-; Gomis González, Maria, 1988-; Delgado García, José María; Gruart, Agnès; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (American Society for Clinical Investigation, 2013)
    Chronic cannabis exposure can lead to cerebellar dysfunction in humans, but the neurobiological mechanisms involved remain incompletely understood. Here, we found that in mice, subchronic administration of the psychoactive ...
  • Overexpression of Dyrk1A, a down syndrome candidate, decreases excitability and impairs gamma oscillations in the prefrontal cortex
    Ruiz Mejias, Marcel; Martínez de Lagrán Cabredo, María; Mattia, Maurizio; Castaño Prat, Patricia; Pérez Mendez, Lorena; Ciria Suarez, Laura; Gener, Thomas; Sancristóbal, Belen; García Ojalvo, Jordi; Gruart, Agnès; Delgado García, José María; Sanchez-Vives, Maria V.; Dierssen, Mara (Society for Neuroscience, 2016)
    The dual-specificity tyrosine phosphorylation-regulated kinase DYRK1A is a serine/threonine kinase involved in neuronal differentiation and synaptic plasticity and a major candidate of Down syndrome brain alterations and ...