Browsing by Author "Delgado Blanco, Javier"

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  • Crépieux, Pascale; Poupon, Anne; Langonné Gallay, Nathalie; Reiter, Éric R.; Delgado Blanco, Javier; Schaefer, Martin H.; Bourquard, Thomas; Serrano Pubull, Luis, 1982-; Kiel, Christina (Frontiers, 2017)
    G protein-coupled receptors (GPCRs) are membrane receptors critically involved in sensing the environment and orchestrating physiological processes. As such, they transduce extracellular signals such as hormone, ...
  • Montero-Blay, Ariadna, 1994-; Delgado Blanco, Javier; Rodriguez-Arce, Irene; Lastrucci, Claire; Piñero-Lambea, Carlos; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (EMBO Press, 2023)
    Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is active as a swapped domain dimer and is used in bacterial therapy of gut inflammation. IL-10 can be used as treatment of a wide range of pulmonary diseases. ...
  • Lluch-Senar, Maria 1982-; Cozzuto, Luca; Cano, Jaime; Delgado Blanco, Javier; Lloréns Rico, Verónica, 1989-; Pereyre, Sabine; Bebear, Cécile; Serrano Pubull, Luis, 1982- (Public Library of Science (PLoS), 2015)
    The human respiratory tract pathogen M. pneumoniae is one of the best characterized minimal bacterium. Until now, two main groups of clinical isolates of this bacterium have been described (types 1 and 2), differing in the ...
  • Lluch-Senar, Maria 1982-; Luong, Khai; Lloréns Rico, Verónica, 1989-; Delgado Blanco, Javier; Fang, Gang; Spittle, Kristi; Clark, Tyson A.; Schadt, Eric; Turner, Stephen W.; Korlach, Jonas; Serrano Pubull, Luis, 1982- (Public Library of Science (PLoS), 2013)
    In the bacterial world, methylation is most commonly associated with restriction-modification systems that provide a defense mechanism against invading foreign genomes. In addition, it is known that methylation plays ...
  • Lluch-Senar, Maria 1982-; Delgado Blanco, Javier; Chen, Wei-Hua; Lloréns Rico, Verónica, 1989-; O’Reilly, Francis J.; Wodke, Judith A.H.; Unal, E. Besray; Yus, Eva; Martínez, Sira; Nichols, Robert J.; Ferrar, Tony; Vivancos Prellezo, Ana; Schmeisky, Arne; Stülke, Jörg; Noort, Vera van; Gavin, Anne-Claude; Bork, Peer; Serrano Pubull, Luis, 1982- (Wiley Blackwell, 2015)
    Identifying all essential genomic components is critical for the assembly of minimal artificial life. In the genome-reduced bacterium Mycoplasma pneumoniae, we found that small ORFs (smORFs; < 100 residues), accounting for ...
  • Miravet Verde, Samuel; Burgos, Raul; Delgado Blanco, Javier; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Oxford University Press, 2020)
    Transposon sequencing is commonly applied for identifying the minimal set of genes required for cellular life; a major challenge in fields such as evolutionary or synthetic biology. However, the scientific community has ...
  • Delgado Blanco, Javier; Radusky, Leandro; Cianferoni, Damiano; Serrano Pubull, Luis, 1982- (Oxford University Press, 2019)
    SUMMARY: A new version of FoldX, whose main new features allows running classic FoldX commands on structures containing RNA molecules and includes a module that allows parametrization of ligands or small molecules (ParamX) ...
  • Delgado Blanco, Javier; Radusky, Leandro; Climente González, Héctor; Serrano Pubull, Luis, 1982- (Oxford University Press, 2018)
    The speed at which new genomes are being sequenced highlights the need for genome-wide methods capable of predicting protein-DNA interactions. Here, we present PADA1, a generic algorithm that accurately models structural ...
  • Delgado Blanco, Javier; Hernandez-Alias, Xavier; Cianferoni, Damiano; Serrano Pubull, Luis, 1982- (Public Library of Science (PLoS), 2020)
    The coronavirus disease COVID-19 constitutes the most severe pandemic of the last decades having caused more than 1 million deaths worldwide. The SARS-CoV-2 virus recognizes the angiotensin converting enzyme 2 (ACE2) on ...
  • Stojanovski, Klement; Ferrar, Tony; Benisty, Hannah, 1986-; Uschner, Friedemann; Delgado Blanco, Javier; Jimenez, Javier; Solé, Carme; Nadal Clanchet, Eulàlia de; Klipp, E., 1965-; Posas Garriga, Francesc; Serrano Pubull, Luis, 1982-; Kiel, Christina (Elsevier, 2017)
    The understanding of interaction dynamics in signaling pathways can shed light on pathway architecture and provide insights into targets for intervention. Here, we explored the relevance of kinetic rate constants of a key ...
  • Piñero-Lambea, Carlos; García Ramallo, Eva; Martínez, Sira; Delgado Blanco, Javier; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (American Chemical Society (ACS), 2020)
    Mycoplasma species share a set of features, such as lack of a cell wall, streamlined genomes, simplified metabolism, and the use of a deviant genetic code, that make them attractive approximations of what a chassis strain ...
  • Suay-Corredera, Carmen; Pricolo, Maria Rosaria; Herrero-Galán, Elías; Velázquez-Carreras, Diana; Sánchez-Ortiz, David; García-Giustiniani, Diego; Delgado Blanco, Javier; Galano-Frutos, Juan José; García-Cebollada, Helena; Vilches, Silvia; Domínguez, Fernando; Sabater Molina, María; Barriales-Villa, Roberto; Frisso, Giulia; Sancho, Javier; Serrano Pubull, Luis, 1982-; García-Pavía, Pablo; Monserrat, Lorenzo; Alegre-Cebollada, Jorge (Elsevier, 2021)
    Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease. Variants in MYBPC3, the gene encoding cardiac myosin-binding protein C (cMyBP-C), are the leading cause of HCM. However, the pathogenicity ...
  • Delgado Blanco, Javier; Radusky, Leandro; Cianferoni, Damiano; Serrano Pubull, Luis, 1982- (National Academy of Sciences, 2019)
    RNA-protein interactions are crucial for such key biological processes as regulation of transcription, splicing, translation, and gene silencing, among many others. Knowing where an RNA molecule interacts with a target ...
  • Cianferoni, Damiano; Radusky, Leandro; Head, Sarah A.; Serrano Pubull, Luis, 1982-; Delgado Blanco, Javier (Oxford University Press, 2020)
    Summary: Accurate 3D modelling of protein-protein interactions (PPI) is essential to compensate for the absence of experimentally determined complex structures. Here, we present a new set of commands within the ModelX ...
  • Martínez-Martín, Inés; Crousilles, Audrey; Ochoa, Juan Pablo; Velázquez-Carreras, Diana; Mortensen, Simon A.; Herrero-Galán, Elías; Delgado Blanco, Javier; Domínguez, Fernando; García-Pavía, Pablo; Sancho, David de; Wilmanns, Matthias; Alegre-Cebollada, Jorge (Elsevier, 2023)
    The underlying genetic defect in most cases of dilated cardiomyopathy (DCM), a common inherited heart disease, remains unknown. Intriguingly, many patients carry single missense variants of uncertain pathogenicity targeting ...
  • Yus, Eva; Güell Cargol, Marc, 1982-; Vivancos Prellezo, Ana; Chen, Wei-Hua; Lluch-Senar, Maria 1982-; Delgado Blanco, Javier; Gavin, Anne-Claude; Bork, Peer; Serrano Pubull, Luis, 1982- (Nature Publishing Group, 2012)
    Here, we report the genome-wide identification of small RNAs associated with transcription start sites (TSSs), termed tssRNAs, in Mycoplasma pneumoniae. tssRNAs were also found to be present in a different bacterial phyla, ...
  • Hernández, Jordi; Bechara, Elias; Schlesinger, Doerte; Delgado Blanco, Javier; Serrano Pubull, Luis, 1982-; Valcárcel, J. (Juan) (Wiley-Blackwell, 2016)
    RBM10 is an RNA binding protein and alternative splicing regulator frequently mutated in lung adenocarcinomas. Recent results indicate that RBM10 inhibits proliferation of lung cancer cells by promoting skipping of exon 9 ...
  • Radusky, Leandro; Modenutti, Carlos; Delgado Blanco, Javier; Bustamante, Juan P.; Vishnopolska, Sebastian; Kiel, Christina; Serrano Pubull, Luis, 1982-; Marti, Marcelo; Turjanski, Adrián (Frontiers, 2018)
    Understanding the functional effect of Single Amino acid Substitutions (SAS), derived from the occurrence of single nucleotide variants (SNVs), and their relation to disease development is a major issue in clinical genomics. ...

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