Browsing by Author "De Llobet, Lara Isabel"

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  • A set of accessible enhancers enables the initial response of breast cancer cells to physiological progestin concentrations
    Zaurín Quer, Roser; Ferrari, Roberto; Nacht, A. Silvina; Carbonell-Caballero, Jose; Le Dily, François; Font Mateu, Jofre, 1977-; De Llobet, Lara Isabel; Vidal Ocabo, Enrique; Lioutas, Antonio, 1980-; Beato, Miguel; Vincent, Guillermo P. (Oxford University Press, 2021)
    Here, we report that in T47D breast cancer cells 50 pM progestin is sufficient to activate cell cycle entry and the progesterone gene expression program. At this concentration, equivalent to the progesterone blood levels ...
  • An RNA polymerase III general transcription factor engages in cell type-specific chromatin looping
    De Llobet, Lara Isabel; Di Vona, Chiara, 1981-; Morselli, Marco; Vezzoli, Marco; Montanini, Barbara; Teichmann, Martin; de la Luna, Susana; Ferrari, Roberto (MDPI, 2022)
    Transcription factors (TFs) bind DNA in a sequence-specific manner and are generally cell type-specific factors and/or developmental master regulators. In contrast, general TFs (GTFs) are part of very large protein complexes ...
  • Hormone-control regions mediate steroid receptor-dependent genome organization
    Le Dily, François; Vidal, Enrique; Cuartero, Yasmina; Quilez Oliete, Javier; Nacht, A. Silvina; Vicent, Guillermo Pablo; Carbonell-Caballero, Jose; Sharma, Priyanka; Villanueva Cañas, José Luis, 1984-; Ferrari, Roberto; De Llobet, Lara Isabel; Verde, Gaetano; Wright, Roni H.G.; Beato, Miguel (Cold Spring Harbor Laboratory Press (CSHL Press), 2019)
    In breast cancer cells, some topologically associating domains (TADs) behave as hormonal gene regulation units, within which gene transcription is coordinately regulated in response to steroid hormones. Here we further ...
  • Stochastic particle unbinding modulates growth dynamics and size of transcription factor condensates in living cells
    Muñoz-Gil, Gorka; Romero-Aristizabal, Catalina; Mateos, Nicolas; Campelo, Felix; De Llobet, Lara Isabel; Beato, Miguel; Lewenstein, Maciej; Garcia-Parajo, Maria F.; Torreno-Pina, Juan A. (National Academy of Sciences, 2022)
    Liquid-liquid phase separation (LLPS) is emerging as a key physical principle for biological organization inside living cells, forming condensates that play important regulatory roles. Inside living nuclei, transcription ...
  • TFIIIC as a potential epigenetic modulator of histone acetylation in human stem cells
    Vezzoli, Marco; De Llobet, Lara Isabel; Di Vona, Chiara, 1981-; Morselli, Marco; Montanini, Barbara; Luna Gargantilla, Susana de la; Teichmann, Martin; Dieci, Giorgio; Ferrari, Roberto (MDPI, 2023)
    Regulation of histone acetylation dictates patterns of gene expression and hence cell identity. Due to their clinical relevance in cancer biology, understanding how human embryonic stem cells (hESCs) regulate their genomic ...
  • TFIIIC binding to alu elements controls gene expression via chromatin looping and histone acetylation
    Ferrari, Roberto; De Llobet, Lara Isabel; Di Vona, Chiara, 1981-; Le Dily, François; Vidal Ocabo, Enrique; Lloutas, Antonios; Quilez Oliete, Javier; Jochem, Laura; Cuts, Erin; Dieci, Giorgio; Vannini, Alessandro; Teichmann, Martin; de la Luna, Susana; Beato, Miguel (Elsevier, 2020)
    How repetitive elements, epigenetic modifications, and architectural proteins interact ensuring proper genome expression remains poorly understood. Here, we report regulatory mechanisms unveiling a central role of Alu ...
  • Unliganded progesterone receptor governs estrogen receptor gene expression by regulating DNA methylation in breast cancer cells
    Verde, Gaetano; De Llobet, Lara Isabel; Wright, Roni H.G.; Quilez Oliete, Javier; Peiró Sales, Sandra; Le Dily, François; Beato, Miguel (MDPI, 2018)
    Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the estrogen and progesterone receptors (ER and PR, respectively). Although much is known about ERα gene (ESR1) regulation ...

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