Browsing by Author "Díez Antón, Juana, 1962-"

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  • A novel translational control mechanism involving RNA structures within coding sequences
    Jungfleisch, Jennifer, 1986-; Nedialkova, Danny D.; Dotu, Ivan; Sloan, Katherine E.; Martínez Bosch, Neus; Brüning, Lukas; Raineri, Emanuele; Navarro Medrano, Pilar; Bohnsack, Markus T.; Leidel, Sebastian; Díez Antón, Juana, 1962- (Cold Spring Harbor Laboratory Press (CSHL Press), 2017)
    The impact of RNA structures in coding sequences (CDS) within mRNAs is poorly understood. Here, we identify a novel and highly conserved mechanism of translational control involving RNA structures within coding sequences ...
  • CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome
    Jungfleisch, Jennifer, 1986-; Böttcher, René; Talló Parra, Marc, 1992-; Pérez Vilaró, Gemma, 1985-; Merits, Andres; Novoa, Eva Maria; Díez Antón, Juana, 1962- (Nature Research, 2022)
    Ample evidence indicates that codon usage bias regulates gene expression. How viruses, such as the emerging mosquito-borne Chikungunya virus (CHIKV), express their genomes at high levels despite an enrichment in rare codons ...
  • Comparison of Xrn1 and Rat1 5' → 3' exoribonucleases in budding yeast supports the specific role of Xrn1 in cotranslational mRNA decay
    Pérez Ortín, José E.; Jordán Pla, Antonio; Zang, Yujie; Moreno García, Jorge; Bassot, Claudio; Barba Aliaga, Marina; Campos Mata, Leire de, 1991-; Choder, Mordechai; Díez Antón, Juana, 1962-; Piazza, Ilaria; Pelechano, Vicent; García Martínez, José (Wiley, 2024)
    The yeast Saccharomyces cerevisiae and most eukaryotes carry two 5' → 3' exoribonuclease paralogs. In yeast, they are called Xrn1, which shuttles between the nucleus and the cytoplasm, and executes major cytoplasmic messenger ...
  • Controlling arbovirus infection: high-throughput transcriptome and proteome insights
    Puig-Torrents, Mireia; Díez Antón, Juana, 1962- (Frontiers, 2024)
    Arboviruses pose a significant threat to public health globally, demanding innovative approaches for their control. For this, a better understanding of the complex web of interactions established in arbovirus-infected ...
  • Elucidation of the epitranscriptomic RNA modification landscape of Chikungunya Virus
    Baquero Pérez, Belinda; Bortoletto, Enrico; Rosani, Umberto; Delgado-Tejedor, Anna; Medina, Rebeca; Novoa, Eva Maria; Venier, Paola; Díez Antón, Juana, 1962- (MDPI, 2024)
    The genomes of positive-sense (+) single-stranded RNA (ssRNA) viruses are believed to be subjected to a wide range of RNA modifications. In this study, we focused on the chikungunya virus (CHIKV) as a model (+) ssRNA virus ...
  • Extensive post-transcriptional buffering of gene expression in the response to severe oxidative stress in baker's yeast
    Blevins, William Robert, 1987-; Tavella, Teresa; Moro, Simone G.; Blasco Moreno, Bernat, 1986-; Closa-Mosquera, Adrià; Díez Antón, Juana, 1962-; Carey, Lucas, 1980-; Albà Soler, Mar (Nature Research, 2019)
    Cells responds to diverse stimuli by changing the levels of specific effector proteins. These changes are usually examined using high throughput RNA sequencing data (RNA-Seq); transcriptional regulation is generally assumed ...
  • From A to m6A: the emerging viral epitranscriptome
    Baquero Pérez, Belinda; Geers, Daryl; Díez Antón, Juana, 1962- (MDPI, 2021)
    There are over 100 different chemical RNA modifications, collectively known as the epitranscriptome. N6-methyladenosine (m6A) is the most commonly found internal RNA modification in cellular mRNAs where it plays important ...
  • Hepatitis C virus infection inhibits P-body granule formation in human livers
    Pérez Vilaró, Gemma, 1985-; Fernández-Carrillo, Carlos; Mensa, Laura; Miquel, Rosa; Sanjuan, Xavier; Forns, Xavier; Pérez del Pulgar, Sofía; Díez Antón, Juana, 1962- (Elsevier, 2015)
    BACKGROUND & AIMS: Decoding the myriad of interactions that hepatitis C virus (HCV) establishes with infected cells is mandatory to obtain a complete understanding of HCV biology and its associated pathogenesis. We and ...
  • Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells
    Chen, Tzu-Chun; Talló Parra, Marc, 1992-; Cao, Qian M.; Kadener, Sebastian; Böttcher, René; Pérez Vilaró, Gemma, 1985-; Boonchuen, Pakpoom; Somboonwiwat, Kunlaya; Díez Antón, Juana, 1962-; Sarnow, Peter (Public Library of Science (PLoS), 2020)
    Viruses subvert macromolecular pathways in infected host cells to aid in viral gene amplification or to counteract innate immune responses. Roles for host-encoded, noncoding RNAs, including microRNAs, have been found to ...
  • Identification of myxobacteria-derived HIV inhibitors by a high-throughput two-step infectivity assay
    Martinez, Javier P.; Hinkelmann, Bettina; Fleta Soriano, Eric, 1983-; Steinmetz, Heinrich; Jansen, Rolf; Díez Antón, Juana, 1962-; Frank, Ronald; Sasse, Florenz; Meyerhans, Andreas (BioMed Central, 2013)
    Drug-resistance and therapy failure due to drug-drug interactions are the main challenges in current treatment against Human Immunodeficiency Virus (HIV) infection. As such, there is a continuous need for the development ...
  • Low zinc levels at admission associates with poor clinical outcomes in SARS-CoV-2 infection
    Vogel-González, Marina; Talló Parra, Marc, 1992-; Herrera-Fernández, Víctor; Pérez Vilaró, Gemma, 1985-; Chillón, Miguel; Nogués Solan, Francesc Xavier; Gómez-Zorrilla, Silvia; López Montesinos, Inmaculada; Arnau-Barrés, Isabel; Sorli Redó, M. Luisa; Horcajada Gallego, Juan Pablo; García-Giralt, Natalia; Pascual Santos, Julio; Díez Antón, Juana, 1962-; Vicente García, Rubén, 1978-; Güerri Fernández, Roberto (MDPI, 2021)
    Background: Zinc is an essential micronutrient that impacts host-pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc ...
  • LSm1-7 complexes bind to specific sites in viral RNA genomes and regulate their translation and replication
    Galão, Rui Pedro Ribeiro; Chari, Ashwin; Alves-Rodrigues, Isabel; Lobão, Daniela; Mas, Antonio Juan; Kambach, Christian; Fischer, Utz; Díez Antón, Juana, 1962- (Cold Spring Harbor Laboratory Press (CSHL Press), 2010)
    LSm1-7 complexes promote cellular mRNA degradation, in addition to translation and replication of positive-strand RNA viruses such as the Brome mosaic virus (BMV). Yet, how LSm1-7 complexes act on their targets remains ...
  • Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation
    Suñer, Clara; Sibilio, Annarita; Martín, Judit; Castellazzi, Chiara Lara; Reina García, Óscar, 1976-; Dotu, Ivan; Caballé, Adrià; Rivas, Elisa; Calderone, Vittorio; Díez Antón, Juana, 1962-; Nebreda, Ángel R.; Méndez de la Iglesia, Raúl (eLife, 2022)
    Chronic inflammation is a major cause of disease. Inflammation resolution is in part directed by the differential stability of mRNAs encoding pro-inflammatory and anti-inflammatory factors. In particular, tristetraprolin ...
  • A mathematical model of rna3 recruitment in the replication cycle of brome mosaic virus
    Huffman, Tori; Link, Kathryn; Nardini, John; Poag, Laura; Flores, Kevin; Banks, H. Thomas; Blasco Moreno, Bernat, 1986-; Jungfleisch, Jennifer, 1986-; Díez Antón, Juana, 1962- (Academic Publications, 2014)
    Positive-strand RNA viruses, such as the brome mosaic virus (BMV) and hepatitis C virus, utilize a replication cycle which involves the recruitment of RNA genomes from the cellular translation machinery to the viral ...
  • Metabolite profiling studies in Saccharomyces cerevisiae: an assisting tool to prioritize host targets for antiviral drug screening.
    Schneider, Konstantin; Krömer, Jens Olaf; Wittmann, Christoph; Alves-Rodrigues, Isabel; Meyerhans, Andreas; Díez Antón, Juana, 1962-; Heinzle, Elmar (BioMed Central, 2009)
    Background The cellular proteins Pat1p, Lsm1p, and Dhh1p are required for the replication of some positive-strand viruses and therefore are potential targets for new antiviral drugs. To prioritize host targets for antiviral ...
  • The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway
    Fleta Soriano, Eric, 1983-; Martinez, Javier P.; Hinkelmann, Bettina; Gerth, Klaus; Washausen, Peter; Díez Antón, Juana, 1962-; Frank, Ronald; Sasse, Florenz; Meyerhans, Andreas (BioMed Central, 2014)
    Background: The nuclear export of unspliced and partially spliced HIV-1 mRNA is mediated by the recognition of a leucine-rich nuclear export signal (NES) in the HIV Rev protein by the host protein CRM1/Exportin1. This makes ...
  • N6-methyladenosine modification is not a general trait of viral RNA genomes
    Baquero Pérez, Belinda; Yonchev, Ivaylo D.; Delgado-Tejedor, Anna; Medina, Rebeca; Puig-Torrents, Mireia; Sudbery, Ian; Begik, Oguzhan; Wilson, Stuart A.; Novoa, Eva Maria; Díez Antón, Juana, 1962- (Nature Research, 2024)
    Despite the nuclear localization of the m6A machinery, the genomes of multiple exclusively-cytoplasmic RNA viruses, such as chikungunya (CHIKV) and dengue (DENV), are reported to be extensively m6A-modified. However, these ...
  • Oligonucleotide-lipid conjugates forming G-quadruplex structures are potent and pangenotypic hepatitis C virus entry inhibitors in vitro and ex vivo
    Koutsoudakis, George; Paris de León, Alexia; Herrera, Carolina; Dorner, Marcus; Pérez Vilaró, Gemma, 1985-; Lyonnais, Sébastien; Grijalvo, Santiago; Eritja, Ramon; Meyerhans, Andreas; Mirambeau, Gilles; Díez Antón, Juana, 1962- (American Society for Microbiology, 2017)
    A hepatitis C virus (HCV) epidemic affecting HIV-infected men who have sex with men (MSM) is expanding worldwide. In spite of the improved cure rates obtained with the new direct-acting antiviral drug (DAA) combinations, ...
  • Pan-genotypic hepatitis C virus inhibition by natural products derived from the wild Egyptian artichoke
    Elsebai, Mahmoud Fahmi; Koutsoudakis, George; Saludes, Verónica; Pérez Vilaró, Gemma, 1985-; Turpeinen, Ari; Mattila, Sampo; Pirttilä, Anna Maria; Fontaine, Fabien; Mehiri, Mohamed; Meyerhans, Andreas; Díez Antón, Juana, 1962- (American Society for Microbiology, 2016)
    Hepatitis C virus (HCV) infection is the leading cause of chronic liver diseases. Water extracts of the leaves of the wild Egyptian artichoke (WEA) [Cynara cardunculus L. var. sylvestris (Lam.) Fiori] have been used for ...
  • Regional and subtype-dependent miRNA signatures in sporadic Creutzfeldt-Jakob disease are accompanied by alterations in miRNA silencing machinery and biogenesis
    Llorens, Franc; Thüne, Katrin; Martí Puig, Eulàlia; Kanata, Eirini; Dafou, Dimitra; Díaz Lucena, Daniela; Vivancos Prellezo, Ana; Shomroni, Orr; Zafar, Saima; Schmitz, Matthias; Michel, Uwe; Fernández Borges, Natalia; Andreóletti, Olivier; del Río, José Antonio; Díez Antón, Juana, 1962-; Fischer, André; Bonn, Stefan; Sklaviadis, Theodoros K.; Torres, Juan María; Ferrer, Isidre; Zerr, Inga (Public Library of Science (PLoS), 2018)
    Increasing evidence indicates that microRNAs (miRNAs) are contributing factors to neurodegeneration. Alterations in miRNA signatures have been reported in several neurodegenerative dementias, but data in prion diseases are ...

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