Browsing by Author "Díez Antón, Juana, 1962-"

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  • Jungfleisch, Jennifer, 1986-; Nedialkova, Danny D.; Dotu, Ivan; Sloan, Katherine E.; Martínez Bosch, Neus; Brüning, Lukas; Raineri, Emanuele; Navarro Medrano, Pilar; Bohnsack, Markus T.; Leidel, Sebastian; Díez Antón, Juana, 1962- (Cold Spring Harbor Laboratory Press (CSHL Press), 2017)
    The impact of RNA structures in coding sequences (CDS) within mRNAs is poorly understood. Here, we identify a novel and highly conserved mechanism of translational control involving RNA structures within coding sequences ...
  • Mina Ibarra, Leonardo Bruno (Universitat Pompeu Fabra, 2010-05-21)
    The group of positive strand RNA ((+)RNA) viruses includes numerous plant, animal and human pathogens such as the hepatitis C virus (HCV). Their viral genomes mimic cellular mRNAs, however, besides acting as messengers for ...
  • Pérez Vilaró, Gemma, 1985- (Universitat Pompeu Fabra, 2012-11-16)
    Els cossos de processament (cossos-P) són grànuls discrets i dinàmics que contenen mRNAs represos en la traducció així com proteïnes involucrades en la degradació dels mRNAs i de la maquinària dels miRNAs. Alguns components ...
  • Pérez Vilaró, Gemma, 1985-; Fernández-Carrillo, Carlos; Mensa, Laura; Miquel, Rosa; Sanjuan, Xavier; Forns, Xavier; Pérez del Pulgar, Sofía; Díez Antón, Juana, 1962- (Elsevier, 2015)
    BACKGROUND & AIMS: Decoding the myriad of interactions that hepatitis C virus (HCV) establishes with infected cells is mandatory to obtain a complete understanding of HCV biology and its associated pathogenesis. We and ...
  • Martinez, Javier P.; Hinkelmann, Bettina; Fleta Soriano, Eric, 1983-; Steinmetz, Heinrich; Jansen, Rolf; Díez Antón, Juana, 1962-; Frank, Ronald; Sasse, Florenz; Meyerhans, Andreas (BioMed Central, 2013)
    Drug-resistance and therapy failure due to drug-drug interactions are the main challenges in current treatment against Human Immunodeficiency Virus (HIV) infection. As such, there is a continuous need for the development ...
  • Galão, Rui Pedro Ribeiro; Chari, Ashwin; Alves-Rodrigues, Isabel; Lobão, Daniela; Mas, Antonio; Kambach, Christian; Fischer, Utz; Díez Antón, Juana, 1962- (Cold Spring Harbor Laboratory Press (CSHL Press), 2010)
    LSm1-7 complexes promote cellular mRNA degradation, in addition to translation and replication of positive-strand RNA viruses such as the Brome mosaic virus (BMV). Yet, how LSm1-7 complexes act on their targets remains ...
  • Huffman, Tori; Link, Kathryn; Nardini, John; Poag, Laura; Flores, Kevin; Banks, H.T.; Blasco, Bernat; Jungfleisch, Jennifer, 1986-; Díez Antón, Juana, 1962- (Academic Publications, 2014)
    Positive-strand RNA viruses, such as the brome mosaic virus (BMV) and hepatitis C virus, utilize a replication cycle which involves the recruitment of RNA genomes from the cellular translation machinery to the viral ...
  • Schneider, Konstantin; Krömer, Jens Olaf; Wittmann, Christoph; Alves-Rodrigues, Isabel; Meyerhans, Andreas; Díez Antón, Juana, 1962-; Heinzle, Elmar (BioMed Central, 2009)
    Background The cellular proteins Pat1p, Lsm1p, and Dhh1p are required for the replication of some positive-strand viruses and therefore are potential targets for new antiviral drugs. To prioritize host targets for antiviral ...
  • Fleta Soriano, Eric, 1983-; Martinez, Javier P.; Hinkelmann, Bettina; Gerth, Klaus; Washausen, Peter; Díez Antón, Juana, 1962-; Frank, Ronald; Sasse, Florenz; Meyerhans, Andreas (BioMed Central, 2014)
    Background: The nuclear export of unspliced and partially spliced HIV-1 mRNA is mediated by the recognition of a leucine-rich nuclear export signal (NES) in the HIV Rev protein by the host protein CRM1/Exportin1. This makes ...
  • Koutsoudakis, George; Paris de León, Alexia; Herrera, Carolina; Dorner, Marcus; Pérez Vilaró, Gemma, 1985-; Lyonnais, Sébastien; Grijalvo, Santiago; Eritja, Ramon; Meyerhans, Andreas; Mirambeau, Gilles; Díez Antón, Juana, 1962- (American Society for Microbiology, 2017)
    A hepatitis C virus (HCV) epidemic affecting HIV-infected men who have sex with men (MSM) is expanding worldwide. In spite of the improved cure rates obtained with the new direct-acting antiviral drug (DAA) combinations, ...
  • Elsebai, Mahmoud Fahmi; Koutsoudakis, George; Saludes, Verónica; Pérez Vilaró, Gemma, 1985-; Turpeinen, Ari; Mattila, Sampo; Pirttilä, Anna Maria; Fontaine, Fabien; Mehiri, Mohamed; Meyerhans, Andreas; Díez Antón, Juana, 1962- (American Society for Microbiology, 2016)
    Hepatitis C virus (HCV) infection is the leading cause of chronic liver diseases. Water extracts of the leaves of the wild Egyptian artichoke (WEA) [Cynara cardunculus L. var. sylvestris (Lam.) Fiori] have been used for ...
  • Llorens, Franc; Thüne, Katrin; Martí Puig, Eulàlia; Kanata, Eirini; Dafou, Dimitra; Díaz Lucena, Daniela; Vivancos Prellezo, Ana; Shomroni, Orr; Zafar, Saima; Schmitz, Matthias; Michel, Uwe; Fernández Borges, Natalia; Andreóletti, Olivier; del Río, José Antonio; Díez Antón, Juana, 1962-; Fischer, André; Bonn, Stefan; Sklaviadis, Theodoros K.; Torres, Juan María; Ferrer, Isidre; Zerr, Inga (Public Library of Science (PLoS), 2018)
    Increasing evidence indicates that microRNAs (miRNAs) are contributing factors to neurodegeneration. Alterations in miRNA signatures have been reported in several neurodegenerative dementias, but data in prion diseases are ...
  • Galão, Rui Pedro Ribeiro (Universitat Pompeu Fabra, 2010-12-01)
    By using the ability of the positive-strand RNA ((+)RNA) virus BMV to replicate in yeast it was previously shown that subunits of the LSm1-7 ring, as well as Pat1 and Dhh1 play an essential role in the transit of the BMV ...
  • Smutná, Katarína, 1991- (Universitat Pompeu Fabra, 2019-02-18)
    The process of HIV latency establishment and maintenance is not clearly understood. Homeostatic proliferation (HSP) is a major mechanism by which long-lived naive and memory CD4 T cells are maintained in vivo. HSP also ...
  • Koutsoudakis, George; Romero-Brey, Inés; Berger, Carola; Pérez Vilaró, Gemma, 1985-; Monteiro Perin, Paula; Vondran, Florian Wolfgang Rudolf; Kalesse, Markus; Harmrolfs, Kirsten; Müller, Rolf; Martínez, Javier P.; Pietschmann, Thomas; Bartenschlager; Ralf; Brönstrup, Mark; Meyerhans, Andreas; Díez Antón, Juana, 1962- (Elsevier, 2015)
    BACKGROUND & AIMS: Soraphen A (SorA) is a myxobacterial metabolite that inhibits the acetyl-CoA carboxylase, a key enzyme in lipid biosynthesis. We have previously identified SorA to efficiently inhibit the human ...
  • Blasco-Moreno, Bernat; de Campos-Mata, Leire; Böttcher, René; García-Martínez, José; Jungfleisch, Jennifer, 1986-; Nedialkova, Danny D.; Chattopadhyay, Shiladitya; Gas, María-Eugenia; Oliva Miguel, Baldomero; Pérez Ortín, José E.; Leidel, Sebastian; Choder, Mordechai; Díez Antón, Juana, 1962- (Nature Research, 2019)
    The highly conserved 5’–3’ exonuclease Xrn1 regulates gene expression in eukaryotes by coupling nuclear DNA transcription to cytosolic mRNA decay. By integrating transcriptome-wide analyses of translation with biochemical ...
  • Jungfleisch, Jennifer, 1986-; Chowdhury, Ashis; Alves-Rodrigues, Isabel; Tharun, Sundaresan; Díez Antón, Juana, 1962- (Cold Spring Harbor Laboratory Press, 2015)
    The Lsm1-7-Pat1 complex binds to the 3' end of cellular mRNAs and promotes 3' end protection and 5'-3' decay. Interestingly, this complex also specifically binds to cis-acting regulatory sequences of viral positive-strand ...
  • Fleta Soriano, Eric, 1983-; Smutna, Katarína; Martinez, Javier P.; Lorca Oró, Cristina; Sadiq, S. Kashif; Mirambeau, Gilles; Lopez-Iglesias, Carmen; Bosch, Marta; Pol, Albert; Brönstrup, Mark; Díez Antón, Juana, 1962-; Meyerhans, Andreas (American Society for Microbiology, 2017)
    Soraphen A is a myxobacterial metabolite that blocks the acetyl-coenzyme A carboxylase of the host and was previously identified as a novel HIV inhibitor. Here, we report that soraphen A acts by reducing virus production ...
  • Doñate-Macián, Pau; Jungfleisch, Jennifer, 1986-; Pérez Vilaró, Gemma, 1985-; Rubio Moscardó, Fanny; Perálvarez Marín, Alex; Díez Antón, Juana, 1962-; Valverde, M. A. (Miguel Ángel), 1963- (Nature Publishing Group, 2018)
    Ion channels are well placed to transduce environmental cues into signals used by cells to generate a wide range of responses, but little is known about their role in the regulation of RNA metabolism. Here we show that the ...
  • Díez Antón, Juana, 1962-; Jungfleisch, Jennifer, 1986- (Taylor & Francis (Routledge), 2017)
    Viruses are powerful tools to uncover cellular processes. Through viral studies we have recently identified a novel translational control mechanism that involves the DEAD-box helicase Dhh1/DDX6 and RNA folding within coding ...