Browsing by Author "D'Agostino, Emma H."

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  • Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist
    Mays, Suzanne G.; Stec, Józef; Liu, Xu; D'Agostino, Emma H.; Whitby, Richard J.; Ortlund, Eric A. (Nature Research, 2020)
    Chirality is an important consideration in drug development: it can influence recognition of the intended target, pharmacokinetics, and off-target effects. Here, we investigate how chirality affects the activity and mechanism ...