Browsing by Author "Cruzat Grand, Josefina, 1983-"

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  • Awakening: Predicting external stimulation to force transitions between different brain states
    Deco, Gustavo; Cruzat Grand, Josefina, 1983-; Cabral, Joana; Tagliazucchi, Enzo; Laufs, Helmut; Logothetis, Nikos K.; Kringelbach, Morten L. (National Academy of Sciences, 2019)
    A fundamental problem in systems neuroscience is how to force a transition from one brain state to another by external driven stimulation in, for example, wakefulness, sleep, coma, or neuropsychiatric diseases. This requires ...
  • Brain songs framework used for discovering the relevant timescale of the human brain
    Deco, Gustavo; Cruzat Grand, Josefina, 1983-; Kringelbach, Morten L. (Nature Research, 2019)
    A key unresolved problem in neuroscience is to determine the relevant timescale for understanding spatiotemporal dynamics across the whole brain. While resting state fMRI reveals networks at an ultraslow timescale (below ...
  • Dynamic coupling of whole-brain neuronal and neurotransmitter systems
    Kringelbach, Morten L.; Cruzat Grand, Josefina, 1983-; Cabral, Joana; Moos Knudsen, Gitte; Carhart-Harris, Robin L.; Whybrow, Peter C.; Logothetis, N.; Deco, Gustavo (National Academy of Sciences, 2020)
    Remarkable progress has come from whole-brain models linking anatomy and function. Paradoxically, it is not clear how a neuronal dynamical system running in the fixed human anatomical connectome can give rise to the rich ...
  • Effects of classic psychedelic drugs on turbulent signatures in brain dynamics
    Cruzat Grand, Josefina, 1983-; Sanz Perl, Yonatan; Escrichs, Anira; Vohryzek, Jakub; Timmermann, Christopher; Roseman, Leor; Luppi, Andrea I.; Ibañez, Agustin; Nutt, David; Carhart-Harris, Robin L.; Tagliazucchi, Enzo; Deco, Gustavo; Kringelbach, Morten L. (MIT Press, 2022)
    Psychedelic drugs show promise as safe and effective treatments for neuropsychiatric disorders, yet their mechanisms of action are not fully understood. A fundamental hypothesis is that psychedelics work by dose-dependently ...
  • Model-based whole-brain perturbational landscape of neurodegenerative diseases
    Sanz Perl, Yonatan; Fittipaldi, Sol; Gonzalez Campo, Cecilia; Moguilner, Sebastián; Cruzat Grand, Josefina, 1983-; Fraile-Vazquez, Matias E.; Herzog, Rubén; Kringelbach, Morten L.; Deco, Gustavo; Prado, Pavel; Ibañez, Agustin; Tagliazucchi, Enzo (eLife, 2023)
    The treatment of neurodegenerative diseases is hindered by lack of interventions capable of steering multimodal whole-brain dynamics towards patterns indicative of preserved brain health. To address this problem, we combined ...
  • Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain’s control energy landscape
    Singleton, S. Parker; Luppi, Andrea I.; Carhart-Harris, Robin L.; Cruzat Grand, Josefina, 1983-; Roseman, Leor; Nutt, David J.; Deco, Gustavo; Kringelbach, Morten L.; Stamatakis, Emmanuel A.; Kuceyeski, Amy (Nature Research, 2022)
    Psychedelics including lysergic acid diethylamide (LSD) and psilocybin temporarily alter subjective experience through their neurochemical effects. Serotonin 2a (5-HT2a) receptor agonism by these compounds is associated ...
  • Temporal irreversibility of large-scale brain dynamics in Alzheimer’s disease
    Cruzat Grand, Josefina, 1983-; Herzog, Rubén; Prado, Pavel; Sanz Perl, Yonatan; Gonzalez-Gomez, Raul; Moguilner, Sebastián; Kringelbach, Morten L.; Deco, Gustavo; Tagliazucchi, Enzo; Ibañez, Agustin (Society for Neuroscience, 2023)
    Healthy brain dynamics can be understood as the emergence of a complex system far from thermodynamic equilibrium. Brain dynamics are temporally irreversible and thus establish a preferred direction in time (i.e., arrow of ...
  • The dynamics of human cognition: increasing global integration coupled with decreasing segregation found using iEEG
    Cruzat Grand, Josefina, 1983-; Deco, Gustavo; Tauste Campo, Adrià, 1982-; Principe, Alessandro; Costa, Albert, 1970-; Kringelbach, Morten L.; Rocamora, Rodrigo (Elsevier, 2018)
    Cognitive processing requires the ability to flexibly integrate and process information across large brain networks. How do brain networks dynamically reorganize to allow broad communication between many different brain ...
  • The Effective communication of brain network dynamics under different states
    Cruzat Grand, Josefina, 1983- (Universitat Pompeu Fabra, 2020-10-09)
    Cognitive processing requires to flexibly combine information from functionally specialized neural processes that are widely distributed throughout the brain. Neuroimaging studies have consistently reported that functional ...
  • The Phase of Theta oscillations modulates successful memory formation at encoding
    Cruzat Grand, Josefina, 1983-; Torralba, Mireia; Ruzzoli, Manuela; Fernández, Alba; Deco, Gustavo; Soto-Faraco, Salvador, 1970- (Elsevier, 2021)
    Several studies have shown that attention and perception can depend upon the phase of ongoing neural oscillations at stimulus onset. Here, we extend this idea to the memory domain. We tested the hypothesis that ongoing ...
  • Whole-brain multimodal neuroimaging model using serotonin receptor maps explains non-linear functional effects of LSD
    Deco, Gustavo; Cruzat Grand, Josefina, 1983-; Cabral, Joana; Knudsen, Gitte M.; Carhart-Harris, Robin L.; Whybrow, Peter C.; Logothetis, Nikos K.; Kringelbach, Morten L. (Elsevier, 2018)
    Understanding the underlying mechanisms of the human brain in health and disease will require models with necessary and sufficient details to explain how function emerges from the underlying anatomy and is shaped by ...