Browsing by Author "Crombach, Anton"

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  • Villaverde, Alejandro F; Henriques, David; Smallbone, Kieran; Bongard, Sophia; Schmid, Joachim; Cicin Sain, Damjan; Crombach, Anton; Sáez Rodríguez, Julio; Mauch, Klaus; Balsa Canto, Eva; Mendes, Pedro; Jaeger, Johannes, 1973-; Banga, Julio R. (BioMed Central, 2015)
    Background: Dynamic modelling is one of the cornerstones of systems biology. Many research efforts are currently being invested in the development and exploitation of large-scale kinetic models. The associated problems of ...
  • Verd Fernández, Berta, 1984-; Crombach, Anton; Jaeger, Johannes, 1973- (BioMed Central, 2014)
    Background: Waddington’s epigenetic landscape is an intuitive metaphor for the developmental and evolutionary potential of biological regulatory processes. It emphasises time-dependence and transient behaviour. Nowadays, ...
  • Verd Fernández, Berta, 1984-; Crombach, Anton; Jaeger, Johannes, 1973- (Public Library of Science (PLoS), 2017)
    Pattern formation during development is a highly dynamic process. In spite of this, few experimental and modelling approaches take into account the explicit time-dependence of the rules governing regulatory systems. We ...
  • Crombach, Anton; Wotton, Karl R.; Jiménez Guri, Eva; Jaeger, Johannes, 1973- (Oxford University Press, 2016)
    Developmental gene networks implement the dynamic regulatory mechanisms that pattern and shape the organism. Over evolutionary time, the wiring of these networks changes, yet the patterning outcome is often preserved, a ...
  • Wotton, Karl R.; Jiménez Guri, Eva; Crombach, Anton; Cicin Sain, Damjan; Jaeger, Johannes, 1973- (Nature Publishing Group, 2015)
    Gap genes are involved in segment determination during early development in dipteran insects (flies, midges, and mosquitoes). We carried out a systematic quantitative comparative analysis of the gap gene network across ...
  • Karl R., Wotton; Jiménez Guri, Eva; Crombach, Anton; Janssens, Hilde; Alcaine Colet, Anna; Lemke, Steffen; Schmidt Ott, Urs; Jaeger, Johannes, 1973- (eLife, 2015)
    The segmentation gene network in insects can produce equivalent phenotypic outputs despite differences in upstream regulatory inputs between species. We investigate the mechanistic basis of this phenomenon through a ...
  • Cicin Sain, Damjan; Hermoso Pulido, Antonio; Crombach, Anton; Wotton, Karl R.; Jiménez Guri, Eva; Taly, Jean-François; Roma, Guglielmo; Jaeger, Johannes, 1973- (Oxford University Press, 2015)
    We present SuperFly (http://superfly.crg.eu), a relational database for quantified spatio-temporal expression data of segmentation genes during early development in different species of dipteran insects (flies, midges and ...