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Browsing by Author "Correia, João D.G."

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Molecular determinants for brain targeting by peptides: a meta-analysis approach with experimental validation

Cavaco, Marco; Fraga, Patrícia; Valle, Javier; Silva, Rúben D.M.; Gano, Lurdes; Correia, João D.G.; Andreu Martínez, David; Castanho, Miguel A.R.B.; Neves, Vera (BioMed Central, 2024)

Blood-brain barrier (BBB) peptide-shuttles (BBBpS) are able to translocate the BBB and reach the brain. Despite the importance of brain targeting in pharmacology, BBBpS are poorly characterized. Currently, their development ...
The use of a selective, nontoxic dual-acting peptide for breast cancer patients with brain metastasis

Cavaco, Marco; Pérez-Peinado, Clara, 1991-; Valle, Javier; Silva, Rúben D.M.; Gano, Lurdes; Correia, João D.G.; Andreu Martínez, David; Castanho, Miguel A.R.B.; Neves, Vera (Elsevier, 2024)

Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by the absence of commonly targeted receptors. Unspecific chemotherapy is currently the main therapeutic option, with poor results. Another major ...
To what extent do fluorophores bias the biological activity of peptides? A practical approach using membrane-active peptides as models

Cavaco, Marco; Pérez-Peinado, Clara, 1991-; Valle, Javier; Silva, Rúben D.M.; Correia, João D.G.; Andreu Martínez, David; Castanho, Miguel A.R.B.; Neves, Vera (Frontiers, 2020)

The characterization of biologically active peptides relies heavily on the study of their efficacy, toxicity, mechanism of action, cellular uptake, or intracellular location, using both in vitro and in vivo studies. These ...

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Browsing by Author "Correia, João D.G."

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