Browsing by Author "Colomo Saperas, Luis Alberto"

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  • Case report: High doses of intravenous immunoglobulins as a successful treatment for late onset immune agranulocytosis after rituximab plus bendamustine
    Díez-Feijóo, Ramón; Rodríguez-Sevilla, Juan José; Fernández Rodríguez, M. Concepción; Flores, Solange; Raya, Carmen; Ferrer, Ana; Colomo Saperas, Luis Alberto; Salar Silvestre, Antonio (Frontiers, 2022)
    Late onset neutropenia (LON) related to rituximab or rituximab plus chemotherapy is defined as an unexplained absolute neutrophil count of ≤1.5 × 109/L starting at least four weeks after the last rituximab administration. ...
  • Cell-Free DNA as a biomarker at diagnosis and follow-up in 256 B and T-Cell lymphomas
    Díez-Feijóo, Ramón; Andrade-Campos, Marcio; Gibert Fernandez, Joan, 1988-; Sánchez González, Blanca; Fernández-Ibarrondo, Lierni; Fernández Rodríguez, M. Concepción; García Gisbert, Nieves, 1994-; Camacho Díaz, Laura; Lafuente, Marta; Vázquez, Ivonne; Colomo Saperas, Luis Alberto; Salar Silvestre, Antonio; Bellosillo Paricio, Beatriz (MDPI, 2024)
    Background: Cell-free DNA (cfDNA) analysis has become a promising tool for the diagnosis, prognosis, and monitoring of lymphoma cases. Until now, research in this area has mainly focused on aggressive lymphomas, with scanty ...
  • Cell-free DNA for genomic analysis in primary mediastinal large B-cell lymphoma
    Rivas-Delgado, Alfredo; Nadeu, Ferran; Andrade-Campos, Marcio; López, Cristina; Enjuanes¸ Anna; Mozas, Pablo; Frigola, Gerard; Colomo Saperas, Luis Alberto; Sánchez González, Blanca; Villamor, Neus; Beà, Sílvia; Campo, Elias; Salar Silvestre, Antonio; Giné, Eva; López Guillermo, Armando; Bellosillo Paricio, Beatriz (MDPI, 2022)
    High-throughput sequencing of cell-free DNA (cfDNA) has emerged as a promising noninvasive approach in lymphomas, being particularly useful when a biopsy specimen is not available for molecular analysis, as it frequently ...
  • Clinical interest of LMO2 testing for the diagnosis of aggressive large B-Cell lymphomas
    Vazquez de las Heras, Ivonne; Papaleo, Natalia; García, Eugenia; Salido Galeote, Marta; Salar Silvestre, Antonio; Hernández Llodrà, Silvia; Calvo Gonzalo, Xavier; Colomo Saperas, Luis Alberto (MDPI, 2020)
    MYC rearrangements usually confer aggressive biological behavior to large B-cell lymphomas. In this study, we aimed to evaluate the relevance of LMO2 detection to the clinical approach to these tumors. First, the ability ...
  • Diagnostic value of genotypic analysis in primary cutaneous lymphomas using standardized BIOMED-2 polymerase chain reaction protocols: experience in daily clinical practice
    López-Aventín, Daniel; Gallardo Hernández, Fernando; Colomo Saperas, Luis Alberto; Moragón, Ester; Vela Ortíz, María del Carmen; Duran Jordà, Xavier, 1974-; Bellosillo Paricio, Beatriz; Pujol Vallverdú, Ramon Maria (Society for Publication of Acta Dermato-Venereologica, 2021)
    BIOMED-2 Concerted Action BMH4-CT98-3936 (BIOMED-2) PCR protocols are an important diagnostic tool in the evaluation of cutaneous lymphomas. The aim of this study was to assess the diagnostic value of the genotyping results ...
  • Dissecting the sCD3-CD4+ T-cell population: A valuable screening tool for angioimmunoblastic T-cell lymphoma
    Rodríguez-Sevilla, Juan José; Ferrer, Ana; Colomo Saperas, Luis Alberto; Sánchez, Blanca; Arenillas Rocha, Leonor; Calvo, Xavier (Wiley, 2022)
  • Evaluation of four prognostic indices in follicular lymphoma treated in first line with immunochemotherapy
    Rodríguez-Sevilla, Juan José; Fernández Rodríguez, M. Concepción; Bento, Leyre; Díez-Feijóo, Ramón; Felipe Pinzon, Sergio; Gibert Fernandez, Joan, 1988-; Fernández-Ibarrondo, Lierni; Lafuente, Marta; Ferrer Del Alamo, Ana; Sánchez González, Blanca; Gimeno Vázquez, Eva; Sainz, Juan; Ramos-Asensio, Rafael; García, Juan Fernando; Colomo Saperas, Luis Alberto; Bellosillo Paricio, Beatriz; Gutierrez, Antonio; Salar Silvestre, Antonio (American Society of Hematology, 2022)
    Several clinical risk models have been proposed to predict outcome in follicular lymphoma (FL). The development of Next Generation Sequencing (NGS) technologies has allowed the integration of somatic gene mutations in ...
  • Evaluation of routine CT scans in the follow-up of diffuse large B-cell lymphomas
    Mascaró-Pol, Martí; Díez-Feijóo, Ramón; Rodríguez-Sevilla, Juan José; Fernández Rodríguez, M. Concepción; García-Pallarols, Francesc; Flores, Solange; Vazquez de las Heras, Ivonne; Rodríguez-Lopez, Saray; Roman-Bravo, David; Gimeno Vázquez, Eva; Colomo Saperas, Luis Alberto; Maiques Llácer, José María; Sanchez Gonzalez, Blanca; Salar Silvestre, Antonio (Taylor & Francis, 2021)
    Objective: Our aim was to retrospectively assess the role of routine CT scans within the first year of follow-up with a limited surveillance policy prior to Lugano recommendations in diffuse large B-cell lymphomas (DLBCL) ...
  • First description of the t(3;17) (q27;q21)/IGF2BP2::LSM12 translocation in marginal zone lymphoma
    Díez-Feijóo, Ramón; Fernández Rodríguez, M. Concepción; Lafuente, Marta; García Gisbert, Nieves, 1994-; Ferrer Del Alamo, Ana; Colomo Saperas, Luis Alberto; Salido Galeote, Marta; Salar Silvestre, Antonio (American Society of Hematology, 2023)
  • Gall bladder and extrahepatic bile duct lymphomas: clinicopathological observations and biological implications
    Mani, Haresh; Climent, Fina; Colomo Saperas, Luis Alberto; Pittaluga, Stefania; Raffeld, Mark; Jaffe, Elaine S. (Lippincott Williams & Wilkins, 2010)
    Lymphomas of the gall bladder and extrahepatic bile ducts are exceedingly rare. We present the clinicopathological features of 19 cases from our files; 14 patients had primary lymphoma (13 involving gall bladder and 1 ...
  • Genetic and phenotypic characterisation of HIV-associated aggressive B-cell non-Hodgkin lymphomas, which do not occur specifically in this population: diagnostic and prognostic implications
    Baptista, Maria Joao; Abella Monreal, Eugenia; Colomo Saperas, Luis Alberto; Navarro, José Tomás (Wiley, 2022)
    The frequency of aggressive subtypes of B-cell non-Hodgkin lymphoma (B-NHL), such as high-grade B-cell lymphomas (HGBL) with MYC and BCL2 and/or BCL6 rearrangement (HGBL-DH/TH) or Burkitt-like lymphoma (BL) with 11q ...
  • IG/MYC rearrangements are the main cytogenetic alteration in plasmablastic lymphomas
    Valera, Alexandra; Balagué, Olga; Colomo Saperas, Luis Alberto; Martínez García, Antonio; Delabie, Jan; Taddesse-Heath, Lekidelu; Jaffe, Elaine S.; Campo, Elias (Lippincott Williams & Wilkins, 2010)
    Plasmablastic lymphoma (PBL) is an aggressive lymphoma characterized by a terminally differentiated B-cell phenotype that usually occurs in the immunocompromised or elderly patients. Although the clinical and pathologic ...
  • Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets
    Karube, Kennosuke; Rubio Pérez, Carlota, 1990-; Tamborero Noguera, David; Salar Silvestre, Antonio; Colomo Saperas, Luis Alberto; López Bigas, Núria; Miyoshi, Hiroaki (Nature Publishing Group, 2018)
    Genome studies of diffuse large B-cell lymphoma (DLBCL) have revealed a large number of somatic mutations and structural alterations. However, the clinical significance of these alterations is still not well defined. In ...
  • Leukemic involvement is a common feature in waldenström macroglobulinemia at diagnosis
    Montesdeoca, Sara; García Gisbert, Nieves, 1994-; Calvo, Xavier; Arenillas Rocha, Leonor; Román, David; Fernández Rodríguez, M. Concepción; Navarro, Rosa; Costan, Beatriz; Vela Ortíz, María del Carmen; Camacho Díaz, Laura; Abella Monreal, Eugenia; Colomo Saperas, Luis Alberto; Salido Galeote, Marta; Puiggros Metje, Anna Maria; Florensa Brichs, Lourdes; Espinet Solà, Blanca; Bellosillo Paricio, Beatriz; Ferrer del Álamo, Anna (MDPI, 2023)
    Waldenström Macroglobulinemia (WM) is a lymphoplasmacytic lymphoma with bone marrow (BM) involvement and IgM monoclonal gammopathy. To date, no studies have focused specifically on peripheral blood (PB) involvement. In ...
  • MicroRNAs 142-3p, miR-155 and miR-203 are deregulated in gastric MALT LymphomasCompared to chronic gastritis
    Fernández Rodríguez, M. Concepción; Bellosillo Paricio, Beatriz; Ferraro Rosset, Mariana Paola; Seoane, Agustín; Sanchez Gonzalez, Blanca; Pairet García, Silvia; Pons, A.; Barranco Sanz, Luis Carlos; Vela Ortíz, María del Carmen; Gimeno Vázquez, Eva; Colomo Saperas, Luis Alberto; Besses Raebel, Carles; Navarro, Alfons; Salar Silvestre, Antonio (International Institute of Anticancer Research (IIAR), 2017)
    BACKGROUND: Over the last years, our knowledge on pathogenesis of gastric MALT lymphoma has greatly improved, but its morphological diagnosis is still hampered by overlapping histological features with advanced chronic ...
  • Mutational profile and pathological features of a case of interleukin-10 and RGS1-positive spindle cCell variant diffuse large B-Cell lymphoma
    Carreras, Joaquim; Kikuti, Yara Yukie; Miyaoka, Masashi; Hiraiwa, Shinichiro; Tomita, Sakura; Ikoma, Haruka; Kondo, Yusuke; Ito, Atsushi; Nagase, Shunsuke; Miura, Hisanobu; Roncador, Giovanna; Colomo Saperas, Luis Alberto; Hamoudi, Rifat; Campo, Elias; Nakamura, Naoya (MDPI, 2023)
    Diffuse large B-cell lymphoma with spindle cell morphology is a rare variant. We present the case of a 74-year-old male who initially presented with a right supraclavicular (lymph) node enlargement. Histological analysis ...
  • Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation
    Garcia-Herrera, Adriana; Song, Joo Y.; Chuang, Shih-Sung; Villamor, Neus; Colomo Saperas, Luis Alberto; Pittaluga, Stefania; Alvaro, Tomas; Rozman, Maria; Anda Gonzalez, Jazmin de; Arrunategui, Ana Maria; Fernandez, Eva; Gonzalvo, Elena; Estrach, Teresa; Colomer Pujol, Dolors; Raffeld, Mark; Gaulard, Philippe; Campo, Elias; Jaffe, Elaine S.; Martinez, Antonio (Lippincott Williams & Wilkins, 2011)
    γδ T cells represent a minor T-cell subset that is mainly distributed in mucosal surfaces. Two distinct lymphomas derived from these cells have been recognized: hepatosplenic γδ T-cell lymphoma (HSTL) and primary cutaneous ...
  • Novel phosphorylated TAK1 species with functional impact on NF-κB and β-catenin signaling in human Cutaneous T-cell lymphoma
    Gallardo Hernández, Fernando; Bertran, Joan; López Arribillaga, Erika, 1986-; González, Jessica; Menéndez, Silvia; Sánchez Güerri, Ignacio; Colomo Saperas, Luis Alberto; Iglesias Coma, Mar; Garrido, Marta; Santamaría-Babí, Luis Francisco; Torres, Ferran; Pujol Vallverdú, Ramon Maria; Bigas Salvans, Anna; Espinosa Blay, Lluís (Nature Publishing Group, 2018)
  • Oligomonocytic and overt chronic myelomonocytic leukemia show similar clinical, genomic, and immunophenotypic features
    Calvo Gonzalo, Xavier; García Gisbert, Nieves, 1994-; Parraga, Ivonne; Gibert, Joan; Florensa Brichs, Lourdes; Andrade-Campos, Marcio; Merchan, Brayan; García-Avila, Sara; Montesdeoca, Sara; Fernández Rodríguez, M. Concepción; Salido Galeote, Marta; Puiggros Metje, Anna Maria; Espinet Solà, Blanca; Colomo Saperas, Luis Alberto; Roman-Bravo, David; Bellosillo Paricio, Beatriz; Ferrer Del Alamo, Ana; Arenillas Rocha, Leonor (American Society of Hematology, 2020)
    Oligomonocytic chronic myelomonocytic leukemia (OM-CMML) is defined as those myelodysplastic syndromes (MDSs) or myelodysplastic/myeloproliferative neoplasms, unclassifiable with relative monocytosis (≥10% monocytes) and ...
  • Outcomes and molecular profile of oligomonocytic CMML support its consideration as the first stage in the CMML continuum
    Calvo González, Xavier; Roman-Bravo, David; García Gisbert, Nieves, 1994-; Rodriguez-Sevilla, Juan José; García-Avila, Sara; Florensa Brichs, Lourdes; Gibert Fernandez, Joan, 1988-; Fernández Rodríguez, M. Concepción; Salido Galeote, Marta; Puiggros Metje, Anna Maria; Espinet Solà, Blanca; Colomo Saperas, Luis Alberto; Bellosillo Paricio, Beatriz; Ferrer, Ana; Arenillas Rocha, Leonor (American Society of Hematology, 2022)
    atients with oligomonocytic chronic myelomonocytic leukemia (OM-CMML) are currently classified according to the 2017 World Health Organization myelodysplastic syndromes classification. However, recent data support considering ...

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