Browsing by Author "Chen, Heng-Chang"

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  • Chen, Heng-Chang; Martínez Vesga, Javier Pablo; Zorita, Eduard; Meyerhans, Andreas; Filion, Guillaume (Nature Publishing Group, 2017)
    The main obstacle to curing HIV is the presence of latent proviruses in the bodies of infected patients. The partial success of reactivation therapies suggests that the genomic context of integrated proviruses can interfere ...
  • Lucic, Bojana; Chen, Heng-Chang; Kuzman, Maja; Zorita, Eduard; Wegner, Julia; Minneker, Vera; Wang, Wei; Fronza, Raffaele; Laufs, Stefanie; Schmidt, Manfred; Stadhouders, Ralph; Roukos, Vassilis; Vlahovicek, Kristian; Filion, Guillaume; Lusic, Marina (Nature Research, 2019)
    HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore compartment in CD4+ T cells. However, the genomic features of these genes and the relevance of their transcriptional activity for ...
  • Vansant, Gerlinde; Chen, Heng-Chang; Zorita, Eduard; Trejbalová, Katerina; Miklík, Dalibor; Filion, Guillaume; Debyser, Zeger (Oxford University Press, 2020)
    HIV-1 persists lifelong in memory cells of the immune system as latent provirus that rebounds upon treatment interruption. Therefore, the latent reservoir is the main target for an HIV cure. Here, we studied the direct ...